Results 81 to 90 of about 639,600 (311)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Causal connectivity maps derived from single-pulse interleaved TMS/fMRI

Scientific Reports
Understanding causal interactions between cortical and subcortical brain regions is critical for mapping human functional connectivity. While non-invasive methods such as fMRI and diffusion imaging have provided valuable insights into brain connectivity,
Lison Bossus, Jess Dickson, Camille Blaine, Hasti Khalilkhani, Ahsan Khan, Desmond J. Oathes   +5 more
doaj   +1 more source

Functional MRI with active, fully implanted, deep brain stimulation systems: Safety and experimental confounds [PDF]

, 2007
We investigated safety issues and potential experimental confounds when performing functional magnetic resonance imaging (fMRI) investigations in human subjects with fully implanted, active, deep brain stimulation (DBS) systems.
Lemieux, L., Thornton, John, Yousry, Tarek, Thobois, S., Pinto, Serge, Allen, P.J., Lemieux, Louis, Carmichael, David, Limousin-Dowsey, Patricia, Pinto, S., Limousin-Dowsey, P., Thornton, J.S., Thobois, Stéphane, Carmichael, D.W., Yousry, T., Allen, Philip   +15 more
core  

Consensus: Can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation? [PDF]

Noninvasive brain stimulation has developed as a promising tool for cognitive neuroscientists. Transcranial magnetic (TMS) and direct current (tDCS) stimulation allow researchers to purposefully enhance or decrease excitability in focal areas of the ...
Born, Jan, Classen, Joseph, Floel, Agnes, Wassermann, Eric M, Cohen, Leonardo G, Gerloff, Christian, Robertson, Edwin M, Pascual-Leone, Alvaro, Reis, Janine, Hummel, Friedhelm, Paulus, Walter, Siebner, Hartwig R, Celnik, Pablo A, Krakauer, John W, Rothwell, John, Marshall, Lisa, Ziemann, Ulf   +16 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Brain Stimulation for Epilepsy: Stimulating Results? [PDF]

Epilepsy Currents, 2006
Long-Term Follow-Up of Patients with Thalamic Deep Brain Stimulation for Epilepsy Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, Wennberg RA Neurology 2006;66:1571–1573 The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or ...
openaire   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Corticomotor Responses to Experimental, Acute, and Chronic Lower Limb Pain: A Systematic Review and Meta‐Analysis

Brain and Behavior
Background: Corticomotor adaptations are believed to contribute to persistent pain. However, prior reviews have lacked sufficient data to adequately explore these adaptations in lower limb pain.
Simon J. Summers, Jawwad Imam, Edward Gray, Ariane Suhood, Ebonie Rio, Cherylea J. Browne, Nadia Moukhaiber, Rocco Cavaleri   +7 more
doaj   +1 more source