Results 71 to 80 of about 2,769,765 (297)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis

, 2019
Background: Brain stimulation interventions are increasingly used to reduce craving and consumption in individuals with drug addiction or excessive eating behavior.
Song, Sensen, Zhou, Xiaolin, Gui, Wenjun, Li, Hui-jie, Zilverstand, Anna   +4 more
core   +1 more source

Brain Stimulation for Epilepsy: Stimulating Results? [PDF]

Epilepsy Currents, 2006
Long-Term Follow-Up of Patients with Thalamic Deep Brain Stimulation for Epilepsy Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, Wennberg RA Neurology 2006;66:1571–1573 The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or ...
openaire   +2 more sources

Exploration of NMDA and GABA receptor-mediated plasticity induced by 10-Hz repetitive transcranial magnetic stimulation

Translational Psychiatry
Although 10-Hz repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, we do not understand the mechanisms through which rTMS induces therapeutic change.
Jamie Kweon, Hakjoo Kim, Prem Ganesh, Megan M. Vigne, Andrew M. Fukuda, Boyu Ren, Linda L. Carpenter, Joshua C. Brown   +7 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism [PDF]

, 2015
The pedunculopontine tegmental nucleus (PPTg) has been proposed as a target for deep brain stimulation (DBS) in parkinsonian patients, particularly for symptoms such as gait and postural difficulties refractory to dopaminergic treatments.
Winn, Philip, Winn, P., Gut, N.K., Gut, Nadine K.   +3 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Effects of striatal transcranial temporal interference stimulation on motor learning after a traumatic brain injury

Traumatic Brain Injury (TBI) is a prevalent neurological condition that follows an externally induced cerebral lesion and is often characterized by impaired cognitive functions.
Nouri, Aria, Schaller, Karl, Léger, Bertrand, Natale, M, Ploumitsakou, Maria, Wessel, Maximilian J., Beanato, Elena, Vassiliadis, Pierre, Maceira-Elvira, Pablo, Hummel, Friedhelm C., Windel, Fabienne, Nencha, Umberto   +11 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Neuronavigated 20hz theta burst TMS of the right orbitofrontal cortex in the treatment of obsessive compulsive disorder

Brain Stimulation, 2023
William Stubbeman, Julianne Converse, Melodi Gencosmanoglu, Daisy Morales Ortega, Jordyn Morris, Raya Khairkhah   +5 more
doaj   +1 more source