Results 51 to 60 of about 2,769,765 (297)

Deep brain stimulation for treatment resistant obsessive compulsive disorder; an observational study with ten patients under real-life conditions

Frontiers in Psychiatry, 2023
IntroductionObsessive-compulsive disorder (OCD) affects 2–3% of the global population, causing distress in many functioning levels. Standard treatments only lead to a partial recovery, and about 10% of the patients remain treatment-resistant.
Mohamed A. Abdelnaim, Mohamed A. Abdelnaim, Verena Lang-Hambauer, Verena Lang-Hambauer, Tobias Hebel, Stefan Schoisswohl, Stefan Schoisswohl, Martin Schecklmann, Daniel Deuter, Daniel Deuter, Juergen Schlaier, Juergen Schlaier, Berthold Langguth, Berthold Langguth   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Deep Brain Stimulation in Schizophrenia [PDF]

Activitas Nervosa Superior, 2014
Abstract Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS.
Kuhn, J., Bodatsch, M., Sturm, V., Lenartz, D., Klosterkötter, J., Uhlhaas, P.J., Winter, C., Gruendler, T.O.J.   +7 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Training-induced cognitive coupling emerges under sham but not active transcranial electrical stimulation in older adults: a triple-blind, randomized, sham-controlled study

Journal of NeuroEngineering and Rehabilitation
Introduction Non-pharmacological methods including training and low-intensity transcranial electrical stimulation (tES) have demonstrated potential in delaying cognitive decline with aging.
Yong Jiang, Xue Guo, Isabella Wistuba, Azadeh Lesani, Ivan Chakalov, Perianen Ramasawmy, Andrea Antal   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

On brain stimulation in epilepsy

Brain
Abstract Brain stimulation has, for many decades, been considered as a potential solution for the unmet needs of the many people living with drug-resistant epilepsy. Clinically, there are several different approaches in use, including vagus nerve stimulation, deep brain stimulation of the thalamus, and responsive neurostimulation. Across
Trevelyan, AJ, Marks, VS, Graham, RT, Denison, T, Jackson, A, Smith, EH   +5 more
openaire   +3 more sources

Inhibit My Disinhibition: The Role of the Inferior Frontal Cortex in Sexual Inhibition and the Modulatory Influence of Sexual Excitation Proneness

Frontiers in Human Neuroscience, 2018
Sexual behaviour is the result of an interplay between distinct neural inhibitory and excitatory mechanisms. Individual differences in sexual excitation and sexual inhibition are proposed to play an important role in the processes sustaining the ...
Geraldine Rodriguez, Alexander T. Sack, Marieke Dewitte, Teresa Schuhmann   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source