Results 81 to 90 of about 1,087,620 (371)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Neural Fiber Activation in Unipolar vs Bipolar Deep Brain Stimulation [PDF]

arXiv, 2023
Deep Brain Stimulation (DBS) is an established and powerful treatment method in various neurological disorders. It involves chronically delivering electrical pulses to a certain stimulation target in the brain in order to alleviate the symptoms of a disease.
arxiv  

Desynchronizing effect of high-frequency stimulation in a generic cortical network model

, 2012
Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most
A Antal, A Antal, A Benabid, A Compte, A Gupta, A Limoge, A Limoge, A Sances Jr, AS Pikovsky, B Nuttin, C Börgers, CC McIntyre, E Schöll, EM Izhikevich, EM Izhikevich, EM Izhikevich, EM Izhikevich, F Velasco, H Markram, J Lian, J Yianni, JA Acebrón, JA Obesó, JD Geyer, Jens Christian Claussen, JL Houeto, KJ Ressler, L Gang, L Garcia, M Steriade, Markus Schütt, P Coubes, R Kumar, R Wang, SC Bellinger, TR Anderson, V Visser-Vandewalle, X Zhang, Y Liu, Y Su   +39 more
core   +1 more source

Large-scale multielectrode recording and stimulation of neural activity [PDF]

, 2007
Large circuits of neurons are employed by the brain to encode and process information. How this encoding and processing is carried out is one of the central questions in neuroscience.
Chichilnisky, E. J., Dabrowski, W., Grillo, A. A., Grivich, M., Gunning, D., Hottowy, P., Kachiguine, S., Litke, A. M., Mathieson, K., Petrusca, D., Sher, A.   +10 more
core   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation. [PDF]

, 2018
Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to
Starr, Philip A
core   +2 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Preliminary Guidelines for Electrode Positioning in Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields [PDF]

arXiv, 2023
Advancements in neurosurgical robotics have improved medical procedures, particularly deep brain stimulation, where robots combine human and machine intelligence to precisely implant electrodes in the brain. While effective, this procedure carries risks and side effects.
arxiv  

Using transcranial direct-current stimulation (tDCS) to understand cognitive processing [PDF]

, 2016
Noninvasive brain stimulation methods are becoming increasingly common tools in the kit of the cognitive scientist. In particular, transcranial direct-current stimulation (tDCS) is showing great promise as a tool to causally manipulate the brain and ...
Cosman, Josh D., Fukuda, Keisuke, Reinhart, Robert M.G., Woodman, Geoffrey F.   +3 more
core   +1 more source

Brain Stimulation for Epilepsy: Stimulating Results? [PDF]

Epilepsy Currents, 2006
Long-Term Follow-Up of Patients with Thalamic Deep Brain Stimulation for Epilepsy Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, Wennberg RA Neurology 2006;66:1571–1573 The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS ...
openaire   +3 more sources