Results 101 to 110 of about 3,399,085 (314)

Manipulation of Innate and Adaptive Immunity through Cancer Vaccines

Journal of Immunology Research, 2017
Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically.
Elias J. Sayour, Duane A. Mitchell
doaj   +1 more source

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity

Molecular Therapy: Oncolytics, 2017
The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in combination with temozolomide (TMZ), the standard chemotherapy for this tumor.
Anne Kleijn, Wouter van den Bossche, Erik S. Haefner, Zineb Belcaid, Chantal Burghoorn-Maas, Jenneke J. Kloezeman, Suzan D. Pas, Sieger Leenstra, Reno Debets, Jeroen de Vrij, Clemens M.F. Dirven, Martine L.M. Lamfers   +11 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications

npj Precision Oncology
Glioblastoma (GBM) poses unique challenges to immunotherapy, owing to its low tumor mutational burden, profound antigenic heterogeneity, and highly immunosuppressive microenvironment.
Cameron M. Hill, Chibueze D. Nwagwu, Angel O. Odukoya, Brian Hsueh, Anthony Z. Wang, Gavin P. Dunn   +5 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Opposite Roles of Furin and PC5A in N-Cadherin Processing

Neoplasia: An International Journal for Oncology Research, 2012
We recently demonstrated that lack of Furin-processing of the N-cadherin precursor (proNCAD) in highly invasive melanoma and brain tumor cells results in the cell-surface expression of a nonadhesive protein favoring cell migration and invasion in vitro ...
Deborah Maret, Mohamad Seyed Sadr, Emad Seyed Sadr, David R Colman, Rolando F Del Maestro, Nabil G Seidah   +5 more
doaj   +1 more source

Amide proton transfer-weighted CEST MRI for radiotherapy target delineation of glioblastoma: a prospective pilot study

European Radiology Experimental
Background Extensive glioblastoma infiltration justifies a 15-mm margin around the gross tumor volume (GTV) to define the radiotherapy clinical target volume (CTV).
Patrick L. Y. Tang, Alejandra Méndez Romero, Remi A. Nout, Caroline van Rij, Cleo Slagter, Annemarie T. Swaak-Kragten, Marion Smits, Esther A. H. Warnert   +7 more
doaj   +1 more source

IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications

Biology
In 2021, the World Health Organization classified isocitrate dehydrogenase (IDH) mutant gliomas as a distinct subgroup of tumors with genetic changes sufficient to enable a complete diagnosis.
Kristian A. Choate, Evan P. S. Pratt, Matthew J. Jennings, Robert J. Winn, Paul B. Mann   +4 more
doaj   +1 more source

Brain Tumor Detection using MR Images through Pixel based Methodology [PDF]

, 2015
Brain tumor a notorious disease has affected and devastated many lives This disease has been the centre of attention of thousands of researchers for many decades around the world Researchers have combined their knowledge and efforts from many areas ...
Md. Abdullah Al Mahmud, Md. Mashiur Rahman, A.H.M. Zadidul Karim   +2 more
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source