Results 71 to 80 of about 3,399,085 (314)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma

Genome Medicine
Background The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastoma patients ...
Changlin Yang, Vrunda Trivedi, Kyle Dyson, Tongjun Gu, Kate M. Candelario, Oleg Yegorov, Duane A. Mitchell   +6 more
doaj   +1 more source

STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma

Nature Communications, 2023
Glioblastoma is an immunologically cold tumour, with poor CD8 + T cell infiltration and enrichment in immunosuppressive tumour-associated myeloid cells. Here, the authors generate a bispecific lipid nanoparticle targeting CD47 and PD-L1, combined with a ...
Peng Zhang, Aida Rashidi, Junfei Zhao, Caylee Silvers, Hanxiang Wang, Brandyn Castro, Abby Ellingwood, Yu Han, Aurora Lopez-Rosas, Markella Zannikou, Crismita Dmello, Rebecca Levine, Ting Xiao, Alex Cordero, Adam M. Sonabend, Irina V. Balyasnikova, Catalina Lee-Chang, Jason Miska, Maciej S. Lesniak   +18 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Brain Tumors in Children [PDF]

Archives of Neurology, 1995
Brain tumors are the most common form of solid neoplasm of childhood. Progress in the treatment of childhood brain tumors has been frustratingly slow, especially in comparison with other pediatric malignancies. The biology of primary pediatric brain tumors of childhood is just being unraveled.
openaire   +4 more sources

Aquaporins and Brain Tumors [PDF]

International Journal of Molecular Sciences, 2016
Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary ...
Rosario Maugeri, Gabriella Schiera, Carlo Di Liegro, Anna Fricano, Domenico Iacopino, Italia Di Liegro   +5 more
openaire   +3 more sources

HealthAgents: distributed multi-agent brain tumor diagnosis and prognosis [PDF]

, 2009
We present an agent-based distributed decision support system for the diagnosis and prognosis of brain tumors developed by the HEALTHAGENTS project. HEALTHAGENTS is a European Union funded research project, which aims to enhance the classification of ...
Dupplaw, D, Horacio González-Vélez, Arvanitis, Thodoros N., Mier, Mariola, Lluch-Ariet, M, Andrew Peet, Robles, Montserrat, Garcia-Gomez, Juan M, Robles Viejo, Monserrat, Celda Muñoz, Bernardo, García-Gómez, JM, Lluch-Ariet, Magí, Magí Lluch-Ariet, Peet, Andrew Charles, Lewis, PH, Peet, Andrew, Paul H. Lewis, Montserrat Robles, Julià-Sapé, M, Mariola Mier, Arvanitis, Theodoros; id_orcid, Carles Arús, Mier, M, Arús, Carles, Celda, Bernardo, Garcia-Gomez, Juan M., Robles, M, Julià-Sapé, Margarida, González-Vélez, H, Sabine Van Huffel, Lewis, Paul H., Dupplaw, David, Van Huffel, Sabine, Margarida Julià-Sapé, Arús, C, David Dupplaw, Juan M. García-Gómez, Arvanitis, Theodoros N., Dasmahapatra, S, Lluch i. Ariet, Magi, Bernardo Celda, Theodoros N. Arvanitis, González-Vélez, Horacio, Huffel, S, Dasmahaptra, Srinandan, Celda, B, Dasmahapatra, Srinandan, Srinandan Dasmahapatra   +47 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

FULLSCREEN > Archive > 2023 > Vol 4, №5 (2023) > Principles of modern brain tumor diagnosis Principles of modern brain tumor diagnosis

, 2023
The paper reports methodology of the current phase of brain tumor recognition. The World Health Organization classification of the central nervous system tumors issued in 2021 and its main differences from the previous version are provided. The molecular
Leonid B. Likhterman, Galina P. Snigireva, Marina V. Ryzhova, Valeriy N. Kornienko, Vladimir A. Okhlopkov, Liudmila V. Shishkina, Natalia E. Zakharova, Artem I. Batalov, Igor N. Pronin   +8 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source