Results 111 to 120 of about 6,149,012 (253)

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

eLife, 2017
Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways.
Jean M. Mulcahy Levy, S. Zahedi, A. Griesinger, Andrew Morin, K. Davies, D. Aisner, B. Kleinschmidt-DeMasters, Brent E. Fitzwalter, Megan L. Goodall, J. Thorburn, V. Amani, A. Donson, D. Birks, D. Mirsky, T. Hankinson, M. Handler, A. Green, Rajeev Vibhakar, N. Foreman, A. Thorburn   +19 more
semanticscholar   +1 more source

Pediatric brain tumors

CA: A Cancer Journal for Clinicians, 1993
Brain tumors are the second most common cancer of children. Although children with brain tumors have a better prognosis than adults, treatment presents special problems, including possible damage to the developing brain. This article reviews the classification, symptoms, diagnosis, and treatment of pediatric brain tumors.
openaire   +2 more sources

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations

Redox Biology
Parkinson's disease (PD), a complex neurodegenerative disorder characterized by selective loss of substantia nigra (SN) dopaminergic neurons, pathological aggregation of α-synuclein (α-syn), and chronic neuroinflammation, is fundamentally driven by redox
Tingting Liu, Xiangrui Kong, Junbo Qiao, Jianshe Wei   +3 more
doaj   +1 more source

Development of a radiomics-based model using computed tomography imaging to assess the incidence of extrapulmonary organ involvement in Mycoplasma pneumoniae pneumonia and to predict recovery times: a multicenter study

Frontiers in Medicine
ObjectivesThis study aimed to develop a predictive model, based on radiomics, to assess the occurrence of extrapulmonary organ involvement and predict recovery durations in children with Mycoplasma pneumoniae pneumonia (MPP).Materials and methodsWe ...
Jiawei Hao, Jiawei Hao, Liyong Zhuo, Liyong Zhuo, Shan Gao, Huan Meng, Zijun Song, Xiaoping Yin, Xiaoping Yin   +8 more
doaj   +1 more source

Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy. [PDF]

, 2019
Glioma is one of the most refractory types of brain tumor. Accurate tumor boundary identification and complete resection of the tumor are essential for glioma removal during brain surgery.
Alfano, Robert R, Cheng, Gangge, Liu, Cheng-Hui, Shi, Lingyan, Wang, Kai, Wu, Binlin, Yu, Xinguang, Zhang, Chunyuan, Zhang, Lin, Zhao, Mingyue, Zhou, Yan, Zhu, Ke, Zong, Rui   +12 more
core   +1 more source

Brain Tumors [PDF]

Physical Therapy, 2002
Christina I, Hill, Cynthia S, Nixon, Jodie L, Ruehmeier, Lisa M, Wolf   +3 more
openaire   +2 more sources

Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A Biomathematical Model and its Therapeutic Implications

, 2012
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hiperplasia.
Calvo, Gabriel F., Martínez-González, Alicia, Pérez-García, Víctor M., Romasanta, Luis A. Pérez   +3 more
core   +1 more source

Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches

Pharmaceutics
Background/Objectives: Medulloblastoma is a rare tumor that represents almost two-thirds of all embryonal pediatric brain tumor cases. Current treatments, including surgery, radiation, and chemotherapy, are often associated with adverse effects, such as ...
Alice Foti, Fabio Allia, Marilena Briglia, Roberta Malaguarnera, Gianpiero Tamburrini, Francesco Cecconi, Vittoria Pagliarini, Francesca Nazio, Adriana Carol Eleonora Graziano   +8 more
doaj   +1 more source

Therapeutic vaccines for malignant brain tumors

Biologics: Targets & Therapy, 2008
Michael P Gustafson1, Keith L Knutson2, Allan B Dietz11Division of Transfusion Medicine; 2Department of Immunology, Mayo Clinic, Rochester, MN, USAAbstract: Malignant gliomas are the most common and aggressive form of brain tumors.
Michael P Gustafson, Keith L Knutson, Allan B Dietz   +2 more
doaj