Results 101 to 110 of about 2,536,308 (310)

The use of conventional and advanced magnetic resonance techniques in the assessment of primary brain tumours [PDF]

, 2008
The aim of the work described in this thesis was to investigate the value of conventional, perfusion- and diffusion-weighted magnetic resonance imaging (MRI) in patients with histology-proven low-grade gliomas (LGG), and the potential role of these ...
Caseiras, G.D.B.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Electrophysiological monitoring of trigeminal nerve sensory root using sensory-masseter response for microvascular decompression in trigeminal neuralgia

Acta Neurochirurgica
Purpose Trigeminal neuralgia (TN), a debilitating condition, is commonly treated with microvascular decompression (MVD). However, effective intraoperative neurophysiological monitoring remains challenging.
Weichao Jiang, Yin Kang, Huijuan Wan, Lihui Lin, Siqi Wu, Hongwei Zhu, Xiaohua Lin, Jiayang Liu, Guowei Tan, Zhanxiang Wang, Xiyao Liu   +10 more
doaj   +1 more source

The phosphoinositide 3-kinase signaling pathway as a therapeutic target in grade IV brain tumors

, 2011
Brain tumors comprise a wide variety of neoplasia classified according to their cellular origin and their morphological and histological characteristics.
A. Arcaro, K. Holand, F. Salm, Salm, F, Höland, K, Arcaro, A   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Clinical roles of EGFR amplification in diffuse gliomas: a real-world study using the 2021 WHO classification of CNS tumors

Frontiers in Neuroscience
BackgroundThe 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, and incorporates EGFR amplification (Amp) as one of diagnostic markers for glioblastoma (GBM).PurposeThis study ...
Hai Wang, Xin Zhang, Jiahui Liu, Wenlin Chen, Xiaopeng Guo, Xiaopeng Guo, Yaning Wang, Yuekun Wang, Hao Xing, Tingyu Liang, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Yu Xia, Yu Xia, Junlin Li, Junlin Li, Jiaming Wu, Jiaming Wu, Qianshu Liu, Qianshu Liu, Tian Qu, Tian Qu, Siying Guo, Siying Guo, Huanzhang Li, Huanzhang Li, Kun Zhang, Kun Zhang, Yilin Li, Yilin Li, Shanmu Jin, Shanmu Jin, Dachun Zhao, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +40 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Brain Tumors

, 2016
Brain tumor cases make up a significant part of the neurosurgery Oral Board Exam. A multitude of brain tumors exist and can be intraaxial or extraaxial.
Alfredo Quiñones-Hinojosa, Chikezie Eseonu, Jordina Rincon-Torroella   +2 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Fas Ligand Expression in Glioblastoma Cell Lines and Primary Astrocytic Brain Tumors

, 1997
Fas/APO-1 (CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand (FasL) or Fas antibody. We previously reported that Fas expression is predominantly induced in perinecrotic glioma cells, suggesting that Fas induction is ...
Tohma, Y., Van Meir, E.G., Paul Kleihues, Gratas, C., Erwin G. Van Meir, Ishii, N., Tachibana, O., Hiroko Ohgaki, Klein, M., Michael Klein, Ohgaki, H., Kleihues, P., Catherine Gratas, Nobuaki Ishii, Yasuo Tohma, Mirna Tenan, Tenan, M., Osamu Tachibana   +17 more
core   +1 more source