Results 111 to 120 of about 2,536,308 (310)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Targeting metabolic mechanisms to overcome temozolomide resistance in glioblastoma

Discover Oncology
Temozolomide (TMZ) resistance remains a major clinical obstacle in the treatment of glioblastoma (GBM), a highly aggressive brain tumor with poor prognosis.
Chengrui Yan, Yulu Ge, Zhan Hu, Wenbin Ma   +3 more
doaj   +1 more source

BRAIN TUMOR

The Journal of Nervous and Mental Disease, 1920
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openaire   +2 more sources

Bioanatomic MRI of Brain Tumors in Animal Models: Implications for Radiation Therapy Treatment Planning and Assessment of Treatment Response

, 2008
Most current radiation therapy techniques for high-grade gliomas are based on anatomical magnetic resonance images (MRI) alone. Magnetic resonance spectroscopy (MRS) and dynamic susceptibility contrast MRI (DSC-MRI) are bioanatomic imaging techniques ...
Atwood, Todd
core  

An Adaptive Xception Model for Classification of Brain Tumors [PDF]

Classification of different brain tumors is challenging due to unpredictable variations in intra-inter-classes. Unlike existing methods which are not effective for images of complex backgrounds, the proposed work aims at accurate classification of ...
Khan, Surbhi Bhatia, Mashat, Arwa, Vinoth Kumar, V., Thakur, Arastu, Almusharraf, Ahlam, Mahesh, T. R., Kumar V, Vinoth, Palaiahnakote, Shivakumara   +7 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging

Genes and Diseases
Parkinson's disease (PD) is a complex neurodegenerative disorder that poses significant burden on patients and families. Its exact cause is unknown, resulting in limited effective treatments.
Tingting Liu, Jingwen Li, Haojie Wu, Junbo Qiao, Jianshe Wei   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors

, 2008
Peptide receptors are often overexpressed in tumors, and they may be targeted in vivo. We evaluated neuropeptide Y (NPY) receptor expression in 131 primary human brain tumors, including gliomas, embryonal tumors, meningiomas, and pituitary adenomas, by ...
Reubi, Jean Claude, Körner, Meike
core