Results 71 to 80 of about 6,149,012 (253)
Childhood brain tumors: current management, biological insights, and future directions.
Journal of Neurosurgery: Pediatrics, 2019 Brain tumors are the most common solid tumors in children, and, unfortunately, many subtypes continue to have a suboptimal long-term outcome. During the last several years, however, remarkable advances in our understanding of the molecular underpinnings ...
I. Pollack, S. Agnihotri, A. Broniscer
semanticscholar +1 more source
Cell Communication and SignalingGlioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%.
Tingyu Liang +6 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The treatment of brain tumors, especially the malignant brain tumors, has entered in the bottleneck period at present. It is difficult for traditional molecular biology, cell and animal experiments to make a major breakthrough in the treatment of brain ...
WANG Jun-cheng +2 more
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CAR T cells for brain tumors: Lessons learned and road ahead
Immunological Reviews, 2019 Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of tumor types, provides hope that immunological approaches will have the ...
D. Akhavan +5 more
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Neurosurgery Clinics of North America, 2021 Peptide and dendritic cell vaccines activate the immune system against tumor antigens to combat brain tumors. Vaccines stimulate a systemic immune response by inducing both antitumor T cells as well as humoral immunity through antibody production to cross the blood-brain barrier and combat brain tumors.
Lee, Justin +2 more
openaire +4 more sources
Cell Death DiscoveryTemozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy.
Wenpeng Zhao +15 more
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USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway
iScienceSummary: METTL3 exhibits distinct tumorigenic roles in the nucleus and cytoplasm, but whether its post-transcriptional modifications vary by subcellular localization remains unclear.
Bingchang Zhang +21 more
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Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]
, 2017 Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro +11 more
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Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
Nature Communications, 2019 Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment.
Jongha Lee +20 more
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Cancer MedicineBackground The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis.
Hao Xing +23 more
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