Results 31 to 40 of about 159,311 (302)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Motor Vehicle Brake Pad Wear—A Review
VehiclesThe paper offers an overview of the motor vehicle brake pad wear process. Considering the types of wear that occur between the pads and the disc, the study begins by presenting Archard’s fundamental wear law. It explains how the hardness and roughness of
Ştefan Voloacă +3 more
doaj +1 more source
Machines, 2023 Brake squeal—an audible high-frequency noise phenomenon in the range between 1 kHz and 15 kHz resulting from self-excited vibrations—is one of the main cost drivers while developing brake systems.
Nils Gräbner +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The effects of filling characteristics on the longitudinal forces developed in the braking train [PDF]
MATEC Web of Conferences, 2019 Determination of longitudinal dynamic forces, size assessment as well as their distribution in the train body is, and will be a subject of global research.
Crăciun Camil Ion, Cruceanu Cătălin
doaj +1 more source
Innovative solution for reducing the run-down time of the chipper disc using a brake clamp device [PDF]
, 2017 Wood-chippers are widely used machines in the forestry, urban and agricultural sectors. The use of these machines implies various risks for workers, primarily the risk of contact with moving and cutting parts.
Cecchini, Massimo +6 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Механика машин, механизмов и материаловThe use of mathematical and computer models to analyze the durability of components in railway rolling stock brake systems and “pantograph — contact wire” systems is considered.
Alexandr O. Shimanovsky +3 more
doaj +1 more source
Linear motor for multi-car elevators, design and position measurement [PDF]
, 2010 Multi-car elevator is an emerging technology consisting of two or more elevator cars moving independently in an elevator hoistway, which has become more appealing as building heights increase.
Gurbuz, Cagri +4 more
core +2 more sources
Robust Spot Melting by 3D Spot Arrangements in Electron Beam Powder Bed Fusion
Advanced Engineering Materials, EarlyView.This work proposes an approach to replace separately melted contours for spot melting in electron beam powder fusion. Adapting the spot arrangements close to the contour combined with stacking yields a comparable surface quality without the inherent challenges of separate contours, as demonstrated, by electron optical images and roughness measurements.
Tobias Kupfer +4 more
wiley +1 more source