Results 101 to 110 of about 19,582 (264)

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li   +12 more
wiley   +1 more source

Mathematical modeling as a basis for creation of the effective braking system of hydraulic press ram in upper position

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012
Single-mass mathematical model of hydraulic press ram braking in upper position is considered. The influence of control valve closing time, its constructive characteristics and coefficient of hydraulic system quality on dynamics of ram braking are ...
Elena S Korchak
doaj  

Cooling Holes in Polymer Spur Gears: A Critical Analysis of Heat Dissipation Benefits and Mesh Stiffness Penalties

open access: yesJournal of Applied Polymer Science, EarlyView.
Cooling holes provide a simple passive cooling strategy for polymer spur gears, reducing maximum operating temperature by up to 9.39% while introducing a measurable gear mesh stiffness penalty. A validated response‐surface model reveals how hole size and location govern this thermal–mechanical trade‐off, enabling design optimization for thermally and ...
Abderrahim Baccar   +5 more
wiley   +1 more source

Scaling and ecomorphology of lagomorph body shape and appendicular skeleton

open access: yesThe Anatomical Record, EarlyView.
Abstract Body shape is one of the most prominent features of phenotypic variation. Yet, mammalian body shapes are poorly quantified and the underlying components contributing to its diversity and its relationship to other skeletal components are rarely tested.
Nia Brice, Coby Huizenga, Chris J. Law
wiley   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith   +23 more
wiley   +1 more source

The ORCA‐TWIN qCMOS Experiment I. Science Case and Commissioning at Calar Alto Observatory

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT We describe a pilot study to explore a new generation of fast and low noise CMOS image sensors for time domain astronomy, using two remote telescopes with a baseline of 1635 km. The experiment involves direct imaging with novel qCMOS image sensor technology that combines fast readout with sub‐electron readout noise.
Martin M. Roth   +20 more
wiley   +1 more source

Temperature of the brakes and the Braking Force

open access: yesTransport and Communications, 2017
Vladimír Rievaj   +2 more
openaire   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

open access: yesBMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang   +6 more
wiley   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

open access: yesBMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li   +9 more
wiley   +1 more source

The Degradation of Access‐Based Business Models: Customer Misbehavior and Shared Mobility

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Access‐based services are considered one of the strategies to embed sustainability in business models. Yet, because the evolution of these business models has been overlooked, we do not know whether their promise to create triple value is sustained.
Andres Camacho, Carmen Valor
wiley   +1 more source

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