Results 31 to 40 of about 48,173 (264)

The Integrated Kinetic Energy Recoup Drive (i-KERD): An Optimized Powertrain for EVs, HEVs and FCEVs

World Electric Vehicle Journal, 2021
In this paper, a particular form of flywheel hybrid powertrain, namely, the Integrated Kinetic Energy Recoup Drive (i-KERD) is fully explored and its applications for EVs, HEVs and FCEVs in recent years to show the energy-savings and performance ...
Min Yang, Tao Wang, Chunji Guo, Chris Ellis, Yuefeng Liao   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Influence of Ventilation Rib Shape and Distribution Density on the Natural Frequency of Brake Discs for Electric Vehicles

Shock and Vibration
These authors contributed equally to this workCurrently, numerous factors contribute to noise generation in automotive brake systems, with brake discs being a primary focus.
Xing-Xing Shangguan, Fu-Jun Shangguan, Feng Gao, Yun-Kao Cai, Chuan-Zheng Xie, Huan-Qi Zhou, Huan-Yang Zhao, Xiao-Jian Ye   +7 more
doaj   +1 more source

Determination of car run up – braking and manoeuvring parameters in an emergency situation in the case of limited road segment [PDF]

Transport, 2005
As the traffic intensity on roads increases, the number of road accidents also increases and the situations become more and more complicated. The presented method of reconstruction of preaccidental situations with the purpose of examination of road ...
O. Lukoševičienė, R. Pečeliūnas
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Analysis of 3^k Experiments Applied to Railway Braking: Influence of Contaminants and Train Speed

Vehicles
The presence of contaminants influences braking efficiency in the railway system because it alters the adhesion at the wheel–rail interface. It is essential to study this phenomenon, as contaminants reduce the friction between wheels and rails, which ...
Tania Elizabeth Sandoval-Valencia, Gerardo Hurtado-Hurtado, Eric Leonardo Huerta-Manzanilla, Dante Ruiz-Robles, Luis Morales-Velázquez, Juan Carlos Jáuregui-Correa   +5 more
doaj   +1 more source

Research of motorcycle braking parameters / Motociklo stabdymo efektyvumo tyrimas

Mokslas: Lietuvos Ateitis, 2016
From a technical point of view, in dangerous or emergency situation is very important motorcycle driver reaction and vehicle braking time. Motor-cycle deceleration parameters depend not only on the motorcycle brake system, but also on the driving ...
Loreta Levulytė, Valdemaras Venckus, Robertas Robertas, Tomas Levulis   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source