Results 41 to 50 of about 64,135 (296)

The Integrated Kinetic Energy Recoup Drive (i-KERD): An Optimized Powertrain for EVs, HEVs and FCEVs

World Electric Vehicle Journal, 2021
In this paper, a particular form of flywheel hybrid powertrain, namely, the Integrated Kinetic Energy Recoup Drive (i-KERD) is fully explored and its applications for EVs, HEVs and FCEVs in recent years to show the energy-savings and performance ...
Min Yang, Tao Wang, Chunji Guo, Chris Ellis, Yuefeng Liao   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Roll- and pitch-plane-coupled hydro-pneumatic suspension. Part 2 dynamic response analyses [PDF]

, 2010
In the first part of this study, the potential performance benefits of fluidically coupled passive suspensions were demonstrated through analyses of suspension properties, design flexibility and feasibility.
Cao, Dongpu, Su, Chun-Yi, Rakheja, Subhash   +2 more
core   +4 more sources

Analysis of 3^k Experiments Applied to Railway Braking: Influence of Contaminants and Train Speed

Vehicles
The presence of contaminants influences braking efficiency in the railway system because it alters the adhesion at the wheel–rail interface. It is essential to study this phenomenon, as contaminants reduce the friction between wheels and rails, which ...
Tania Elizabeth Sandoval-Valencia, Gerardo Hurtado-Hurtado, Eric Leonardo Huerta-Manzanilla, Dante Ruiz-Robles, Luis Morales-Velázquez, Juan Carlos Jáuregui-Correa   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Research of motorcycle braking parameters / Motociklo stabdymo efektyvumo tyrimas

Mokslas: Lietuvos Ateitis, 2016
From a technical point of view, in dangerous or emergency situation is very important motorcycle driver reaction and vehicle braking time. Motor-cycle deceleration parameters depend not only on the motorcycle brake system, but also on the driving ...
Loreta Levulytė, Valdemaras Venckus, Robertas Robertas, Tomas Levulis   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A new braking torque distribution strategy based on braking actuator characteristics and a command signal for a blended braking system

, 2022
Braking torque distribution strategy is not only related to the tracking performance of the blended braking system in commanding the braking signal, but is also related to the energy utilization efficiency of the blended braking system.
Haiping Du (6500786), Wenfei Li (1461220), Zhejun Huang (8407446), Jia Liu (41593), Shaobo Dang (20259933), Huiyun Li (2543647)   +5 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source