Results 61 to 70 of about 19,582 (264)

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, EarlyView.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Influence of VANET System on Movement of Traffic Flows in Emergency Situations

Promet (Zagreb), 2015
The paper presents Vehicular Ad Hoc Network (VANET) system based on an analysis of the movement of a motorcade in an emergency situation. This analysis seeks to answer the question: when and under what conditions Emergency Message (EM) sent by Vehicle-to-
Algimantas Kajackas, Vidas Žuraulis, Edgar Sokolovskij   +2 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Analysis of emergency braking of a vehicle

Transport, 2007
In this paper, braking of cars is analyzed: the analytic formulas for description of the said process and the diagrams for its illustration are provided, its mode of operation when the wheels of the car are not blocked is discussed upon, the most ...
Nerijus Kudarauskas
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Overviewing Braking Technology of the High-speed Trains

机车电传动, 2011
The relationship between the braking system and the security of the high-speed trains was expounded, comparative analysis about the brake modes and the corresponding braking performance as well as reviews of their domestic and oversea applications was ...
张建柏, 彭辉水, 倪大成, 刘雄
doaj  

Changing the Position of the Vehicle’s Center of Gravity as a Result of Different Load Distribution

Applied Sciences
Dynamical vehicle performances depend on its center of gravity’s position. It is necessary to determine this position as closely as possible. The current methods of determining the center of gravity’s position are either not sufficiently accurate or are ...
František Synák, Eva Nedeliaková
doaj   +1 more source

Effect of lateral stiffness of secondary suspensions on heavy-haul locomotives stability during braking based on simulation and experiment

Transport, 2019
This paper aimed to investigate the effect of the lateral stiffness of secondary suspensions on the stability capacity and running safety of heavy-haul locomotives during braking based on the dynamic model and the field braking tests.
Lirong Guo, Kaiyun Wang, Zaigang Chen, Zhiyong Shi, Kaikai Lv, Rui Zhang   +5 more
doaj   +1 more source