Results 71 to 80 of about 48,173 (264)

Dynamics of railway wagons subjected to braking/traction torque

, 2009
Braking or traction torque is regarded as an important source of wheelset skid and a potential source of derailment risk that adversely affects the safety levels of train operations; therefore, this research examines the effect of braking/traction torque
Zhang, Zuoyan, Dhanasekar, Manicka
core   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Tread braking of railway wheels ─ state-of-the-art survey

, 2010
An overview of design methods for tread braking systems is given with special focus on the braking capacity of the wheels. Several aspects of the tread braking system, important for the dimensioning of railway wheels, are assessed, such as brake block ...
Teimourimanesh, Shahab,, Lundén, Roger,, Vernersson, Tore V,   +2 more
core  

Heavy vehicle pitch dynamics and suspension tuning [PDF]

, 2008
The influence of suspension tuning of passenger cars on bounce and pitch ride performance has been explored in a number of studies, while only minimal efforts have been made for establishing similar rules for heavy vehicles.
Cao, Dongpu, Su, Chun-Yi, Rakheja, Subhash   +2 more
core  

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Braking traces vs. vehicle braking deceleration

, 2022
W artykule przeanalizowano proces hamowania samochodu z zablokowaniem kół przedniej lub tylnej osi. Wyznaczono zakres wartości, w którym mieści się opóźnienie pojazdu podczas hamowania z pozostawieniem śladów ogumienia na nawierzchni.
Fundowicz, Piotr
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Influence of VANET System on Movement of Traffic Flows in Emergency Situations

Promet (Zagreb), 2015
The paper presents Vehicular Ad Hoc Network (VANET) system based on an analysis of the movement of a motorcade in an emergency situation. This analysis seeks to answer the question: when and under what conditions Emergency Message (EM) sent by Vehicle-to-
Algimantas Kajackas, Vidas Žuraulis, Edgar Sokolovskij   +2 more
doaj   +1 more source

A practical demonstration of electromagnetic braking

, 2007
The topic of electromagnetics is of fundamental importance to electrical power engineering education. Graduates of electrical engineering, particularly those who specialise in electrical power engineering are expected to develop an adequate understanding
C. G. Wells, Ahfock, T., T. Ahfock, Wells, C. G.   +3 more
core   +1 more source