Results 31 to 40 of about 11,483,484 (290)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Single-Wheel Failure Stability Control for Vehicle Equipped with Brake-by-Wire System

World Electric Vehicle Journal, 2023
In order to solve the problem of vehicle stability control after a single-wheel brake failure in the brake-by-wire system, a control strategy of braking force redistribution with a yaw moment is proposed to ensure the braking efficiency and stability of ...
Jian Zhou, Yage Di, Xuelong Miao
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Electronic mechanical braking system executive mechanism design, calculation, and modeling based on dynamic control

Frontiers in Mechanical Engineering
Introduction: As science and technology develop, automobiles are moving toward intelligence and electrification and need better braking systems.Methods: To improve the braking system’s response speed and braking effect, a longitudinal dynamics control ...
Xinping Wu, Rongnian He, Han Ge, Mengyu Chen   +3 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Design of Electro-mechanical Braking System

Chengshi guidao jiaotong yanjiu
ObjectiveTo address the issues of significant braking force dispersion, long braking response times, and high braking impact of maglev trains, an application study of EMB (electro-mechanical braking) technology on maglev vehicles is carried out ...
Huijie DU, Limin ZHANG, Zhaokai ZHU, Xinsheng YANG, Lin WANG   +4 more
doaj   +1 more source

Research on Regenerative Braking of Pure Electric Mining Dump Truck

World Electric Vehicle Journal, 2019
When the pure electric mining dump truck is working, it mainly ascends the slope at full load and descends the slope at no load. The loading state of the vehicle and the slope of the road will directly affect its axle load distribution and braking force ...
Wei Zhang, Jue Yang, Wenming Zhang, Fei Ma   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Design of downhill regenerative braking control method for hybrid electric vehicle [PDF]

, 2023
In order to improve the downhill regenerative braking control effect of hybrid electric vehicle (HEV), this paper designs a downhill regenerative braking control method for hybrid electric vehicle (HEV).
Miao, Jia, Jia Miao
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source