Results 101 to 110 of about 82,803 (297)

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Interface temperatures in friction braking [PDF]

, 2002
YesResults and analysis from investigations into the behaviour of the interfacial layer (Tribolayer) at the friction interface of a brake friction pair (resin bonded composite friction material and cast iron rotor) are presented in which the disc/pad ...
Day, Andrew J., Noor, K., Qi, Hong Sheng
core  

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Heat generation problem in the eddy current brake: a mini-review

Cogent Engineering
One of the functions of a brake system is to reduce or maintain the speed of a vehicle. The braking process generally converts kinetic energy into heat.
M. R. A Putra, Ubaidillah, D. D. D. P. Tjahjana, M. Nizam, Z. Arifin, H. T. Waloyo, Bhre Wangsa Lenggana   +6 more
doaj   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Influence of Rail Temperature on Braking Efficiency in Railway Vehicles

Eng
Railway braking efficiency hinges on the thermomechanical conditions at the wheel-rail interface. Frictional heating during operation causes significant temperature fluctuations, directly impacting braking performance in rail vehicles.
Diego Rivera-Reyes, Tania Elizabeth Sandoval-Valencia, Juan Carlos Jáuregui-Correa   +2 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Investigation of Physical, Mechanical and Tribological Properties of Blast Furnace Dust Reinforced Bronze Matrix Composite Brake Pads

Gazi Üniversitesi Fen Bilimleri Dergisi
This research aims to investigate the usability of Blast Furnace Dust (BFD), an industrial waste material, as a reinforcing element in metal matrix composite brake pads and the effects of BFD reinforcement on the brake pad's tribological, physical, and ...
Hüsamettin Kuş , İlker Sugözü, Adem Avcu   +2 more
doaj   +1 more source

Analysis of air flow and heat dissipation from a high performance passenger car front brake rotor [PDF]

, 2006
The increasing demand from the consumer for higher levels of refinement from their passenger vehicles has put considerable pressure on the automotive industry to produce ever quieter cars. In order to prevent the occurrence of many forms of brake noise,
Fieldhouse, John D., Mishra, Rakesh, Palmer, Edward   +2 more
core  

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source