Results 91 to 100 of about 82,803 (297)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Research on the Maximum Disc Surface Temperature and Thermal-mechanical Coupling Characteristics of Train Brake Pair

Journal of Harbin University of Science and Technology
The high temperature generated by train braking affects the mechanical properties of the brake materials, and there is an interaction between them, affecting the braking performance of the train.
YU Chunyu, LI Weipu, GUO Yang, HONG Fanli, ZHANG Qinghai, GAO Jianwei   +5 more
doaj   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

A Multi-Source Braking Force Control Method for Electric Vehicles Considering Energy Economy

Energies
Advancements in electric vehicle technology have promoted the development trend of smart and low-carbon environmental protection. The design and optimization of electric vehicle braking systems faces multiple challenges, including the reasonable ...
Yinhang Wang, Liqing Zhou, Liang Chu, Di Zhao, Zhiqi Guo, Zewei Jiang   +5 more
doaj   +1 more source

Effect of Friction Model and Tire Maneuvering on Tire-Pavement Contact Stress

Advances in Materials Science and Engineering, 2015
This paper aims to simulate the effects of different friction models on tire braking. A truck radial tire (295/80R22.5) was modeled and the model was validated with tire deflection. An exponential decay friction model that considers the effect of sliding
Haichao Zhou, Guolin Wang, Yangmin Ding, Jian Yang, Chen Liang, Jing Fu   +5 more
doaj   +1 more source

Research on Regenerative Braking of Pure Electric Mining Dump Truck

World Electric Vehicle Journal, 2019
When the pure electric mining dump truck is working, it mainly ascends the slope at full load and descends the slope at no load. The loading state of the vehicle and the slope of the road will directly affect its axle load distribution and braking force ...
Wei Zhang, Jue Yang, Wenming Zhang, Fei Ma   +3 more
doaj   +1 more source

Nanoscale Covalent Organic Framework Confinement Enables Ultratough and Hyperelastic Hydrogels Applied as High‐Performance Electrolytes

Advanced Science, EarlyView.
Confinement by nanoscale covalent organic frameworks reinforces hydrogels, imparting exceptional mechanical strength and ionic conductivity for high‐performance electrolyte applications. ABSTRACT Hydrogels are widely applied in various fields, including energy storage and flexible electronics. However, their mechanical properties often fail to meet the
Peiyao Yan, Wei Zhao, Hao Wang, Lu Wu, Yedong Ma, Binting Huang, Hantao Xu, Xueyan Liu, Siqi Liu, Xinyu Dong, Xiaoyang Zhang, Wei Zhai, Weiwei Zhang, Lin Xu, Dan Zhao, Chaobin He   +15 more
wiley   +1 more source

Modeling of air braking process of 20 000 ton heavy haul train

机车电传动, 2022
In view of the limited accuracy of the traction calculation method specified in the code for train traction calculation in solving the air braking process of 20 000 ton heavy haul combined trains, based on the existing air braking calculation model of ...
WANG Qingyuan, ZHAO Zining, LIU Qiangqiang, WANG Kaiyun, RAO Yu, SUN Pengfei   +5 more
doaj  

Are You Used To It Yet? Braking Performance and Adaptation in a Fixed-base Driving Simulator. [PDF]

, 2003
During braking-to-stop manoeuvres in a fixed-base driving simulator, the paucity of visual and vestibular cues can lead to driver misperception and produce different patterns of braking response between real and simulated driving.
Jamson, A.H., Smith, P.
core  

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source