Results 211 to 220 of about 82,803 (297)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Lower-limb strength and power characteristics in relation to 180° change of direction ability in elite female basketball players. [PDF]

Front Sports Act Living
Ogata H, Yamashita D, Nishikawa N, Yokozawa T, Hoshikawa M.   +4 more
europepmc   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

DLLT: A dual-layer LSTM-transformer model for real-time energy and dynamics prediction in plug-in hybrid electric vehicles. [PDF]

PLoS One
Zhang X, Chen Z, Fang X.
europepmc   +1 more source

Guest Editorial: Computational Intelligence in Dynamic and Uncertain Environments

CAAI Transactions on Intelligence Technology, EarlyView.
Shouyong Jiang
wiley   +1 more source

Parent's Perceptions of the Family Impacts of COVID‐19 Lockdowns on Themselves and Siblings of Children With Developmental Disabilities: ‘No Time to Breathe’

Child &Family Social Work, EarlyView.
ABSTRACT Family members may be impacted by complex care requirements around childhood disability, although little research provides guidance on the changing needs of families under unexpected circumstances. This study investigated parents' experiences and reports of the impact of COVID‐19 lockdowns in Australia on family members in families raising a ...
Helen Bourke‐Taylor, Monica Leo, Loredana Tirlea, Ayla Baydan, Ted Brown, Luke Robinson, Tim Moore   +6 more
wiley   +1 more source

Tribological characteristics of composite brake pads under variable load and speed. [PDF]

Sci Rep
Essam MA, Faragallah MM, Abdeltawab NM, Ali M.   +3 more
europepmc   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Comparison of Sprint Deceleration Capacity in Front- and Side-Facing End Stances in Multidirectional Team Sport Athletes. [PDF]

Eur J Sport Sci
West MA, Compton HR, Dascombe BJ, Secomb JL.   +3 more
europepmc   +1 more source

The specifics of non‐routine task changes: A granular approach

Contemporary Economic Policy, EarlyView.
Abstract This paper estimates granular specific non‐routine tasks and examines employment reallocation across those tasks in the United States. Employment shifts into decision‐making, technology, and information‐related tasks account for 90% of high‐wage employment growth.
Carol A. Scotese
wiley   +1 more source