Results 31 to 40 of about 56,974 (249)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Branch-and-price algorithm flowchart.
, 2018 Branch-and-price algorithm flowchart.
Tianwei Zhang (169823) +2 more
core +1 more source
EURO Journal on Transportation and Logistics, 2023 Due to the uncertain nature of the traffic system, it is not trivial for delivery companies to reliably satisfy customers’ time windows. To guarantee the reliability of the pickup and delivery service under stochastic and time-dependent travel times, we ...
Zheyu Wang +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Management and Business Review, 2019 Penelitian ini bertujuan untuk mengetahui (1) Bagaimana pengaruh harga, word of mouth dan citra merek secara simultan terhadap keputusan pembelian pada Event Organizer pada UN Production, dan Bagaimana pengaruh harga, word of mouth dan citra merek secara
Nourma Wulanda +2 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Algorithme de Branch and Price pour la confection d'horaires d'infirmières [PDF]
, 2004 Problématique et méthode utilisée -- Présentation du problème de confection d'horaires d'infirmières -- Revue des méthodes existantes -- Description et modélisation du problème NSP1 -- Méthode retenue -- Description et modélisation du problème NSP2 -- L ...
Doyon, Jean-Philippe
core +1 more source
EnergiesTo address the high volatility of spot market prices and the feature extraction limitations of single models, a short-term electricity price forecasting method based on a reinforcement learning dynamic soft ensemble strategy is proposed.
Yan Wang +3 more
doaj +1 more source
A branch-and-price algorithm for two-echelon electric vehicle routing problem
Complex & Intelligent Systems, 2021 Motivated by express and e-commerce companies’ distribution practices, we study a two-echelon electric vehicle routing problem. In this problem, fuel-powered vehicles are used to transport goods from a depot to intermediate facilities (satellites) in the
Zhiguo Wu, Juliang Zhang
doaj +1 more source