Results 41 to 50 of about 44,963 (303)

Branch-and-Price for Prescriptive Contagion Analytics

Operations Research
A new optimization methodology helps allocate vaccines to combat a pandemic. During the COVID-19 pandemic, the extraordinary speed of vaccine developments quickly gave rise to a critical operational problem: How to distribute a scarce stockpile of vaccines across communities? In “Branch-and-Price for Prescriptive Contagion Analytics,” A.
Alexandre Jacquillat, Michael Lingzhi Li, Martin Ramé, Kai Wang   +3 more
openaire   +3 more sources

Hierarchical Ring Network Design Using Branch-and-Price [PDF]

Telecommunication Systems, 2005
We consider the problem of designing hierarchical two layer ring networks. The top layer consists of a federal-ring which establishes connection between a number of node disjoint metro-rings in a bottom layer. The objective is to minimize the costs of links in the network, taking both the fixed link establishment costs and the link capacity costs into ...
Thomadsen, Tommy, Stidsen, Thomas K.
openaire   +2 more sources

Tactical fixed job scheduling with spread-time constraints [PDF]

, 2014
We address the tactical fixed job scheduling problem with spread-time constraints. In such a problem, there are a fixed number of classes of machines and a fixed number of groups of jobs.
Chen, Bo, Velde, Steef van de, Zhang, Xiandong, Zhou, Shuyu   +3 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Short-Term Electricity Price Forecasting via a Reinforcement Learning-Based Dynamic Soft Ensemble Strategy

Energies
To address the high volatility of spot market prices and the feature extraction limitations of single models, a short-term electricity price forecasting method based on a reinforcement learning dynamic soft ensemble strategy is proposed.
Yan Wang, Yongxi Zhao, Kun Liang, Hong Fan   +3 more
doaj   +1 more source

Segmenting wine markets with diverse price functions: Evidence from California red and white wines sold in British Columbia

Wine Economics and Policy, 2017
Previous hedonic price studies on wine market segments, exploring diverse price functions, are constrained by pre-determined price breakpoints, the total number of segments, or both.
Richard Carew, Wojciech J. Florkowski, Ting Meng   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Influence of Products and Prices on Customer Loyality At the Sharia People's Economic Bank Bakti Makmur Indah Main Branch Office in Sidoarjo

International Journal of Islamic Thought and Humanities
Sharia People's Economic Bank Bakti Makmur Indah Main Branch Office Throughout is one of the sharia banks that has great potential in developing an economy based on Islamic values.
Abdul Majid Toyyibi, Muhammad Adi Satria
doaj   +1 more source

Using Branch-and-Price to Find High Quality Solutions Quickly [PDF]

, 2009
We develop an exact solution approach for integer programs that produces high- quality solutions quickly by solving well-chosen restrictions of the problem.
Hewitt, Mike, Nemhauser, George, Savelsbergh, Martin   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source