Results 61 to 70 of about 44,963 (303)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Orphanet Journal of Rare DiseasesBackground Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, disabling genetic disorder condition that lacks real-world evidence on disease burden.
Xiaoyang Xu +7 more
doaj +1 more source
Gestão & Produção, 2008 This paper presents a proposal for optimizing the public health service in the state of Parana in terms of the flow of patients within the state's boundaries and the regionalization (division) of the state into new hierarchical configurations for this ...
Cassius Tadeu Scarpin +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Research evaluation of mechanical cutting technology of mulberry branch
Journal of Hebei University of Science and Technology, 2016 China is the world's largest silkworm cocoon and raw silk producer and exporter. However, as the labor price increases quickly, the sericulture production costs increases, the comparative benefits of sericulture production decreases, and the farmers ...
Zhanhua SONG +4 more
doaj +1 more source
Circulation of railway rolling stock: a branch-and-price approach [PDF]
Computers & Operations Research, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Peeters, M., Kroon, L.G.
openaire +3 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Dispariti of prices in the agrarian economy of Russia
Путеводитель предпринимателя, 2020 In the basis of the presented analysis of branch features of pricing in agriculture, dynamics of price indices for manufactured goods and agricultural products it is justified that the price parity violation largely determines the current development of ...
N. R. Amirova, L. V. Sargina
doaj
Cargo Consolidation and Distribution Through a Terminals-Network: A Branch-And-Price Approach [PDF]
, 2017 Less-than-truckload is a transport modality that includes many practical variations to convey a number of transportation-requests from the origin locations to their destinations by using the possibility of goods-transshipments on the carrier?s terminals-
Dondo, Rodolfo Gabriel
core +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source