Results 41 to 50 of about 773,474 (304)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Segmenting wine markets with diverse price functions: Evidence from California red and white wines sold in British Columbia

open access: yesWine Economics and Policy, 2017
Previous hedonic price studies on wine market segments, exploring diverse price functions, are constrained by pre-determined price breakpoints, the total number of segments, or both.
Richard Carew   +2 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

THE INFLUENCES OF PRODUCT, PRICE, PROMOTION, PLACE, AND SERVICE QUALITY TOWARDS CUSTOMER SATISFACTION

open access: yesProfit: Jurnal Kajian Ekonomi dan Perbankan Syariah
This study aims to analyze the influence of product, price, promotion, location, and service quality on customer satisfaction at PT. Bank Muamalat Indonesia Semarang Branch Office, both simultaneously and partially.
Muhamad Banu Kamal Alfirdaus   +1 more
doaj   +1 more source

NALISIS MEREK DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN DI PT.TIKI JNE (STUDI KASUS DI PT. TIKI JNE CABANG DENPASAR, BALI) [PDF]

open access: yes, 2006
The development and improvement express delivery of service (courier) from many years’ increases in accordance with society necessities. It can be seen by the strong competition in servicing, price, and promotion among many of ...
FEBRIANI ZEIN, MINDI
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Estudio de modelos de apoyo al proceso de asignación de cupos escolares en el sistema de educación pública del distrito capital

open access: yesRevista UIS Ingenierías, 2007
En el proceso de asignación de cupos escolares, en los colegios públicos del distrito de Bogota, es posible identificarcomo una situación problemática la asignación de cupos a los estudiantes que ingresan nuevos al sistema de educaciónpública.
Pablo Andrés Maya Duque
doaj  

Branch-and-Price for Prescriptive Contagion Analytics

open access: yesOperations Research
A new optimization methodology helps allocate vaccines to combat a pandemic. During the COVID-19 pandemic, the extraordinary speed of vaccine developments quickly gave rise to a critical operational problem: How to distribute a scarce stockpile of vaccines across communities? In “Branch-and-Price for Prescriptive Contagion Analytics,” A.
Alexandre Jacquillat   +3 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

BaPCod - a generic branch-and-price code

open access: yes, 2021
This document presents a user guide for BaPCod version 0.63, a C++ library implementing a generic branch-cut-and-price solver. We give guidelines for installing BaPCod, using its modelling language, BaPCod parameterization, retrieving BaPCod statistics, and understanding BaP-Cod output. We also present the VRPSolver extension of BaPCod which allows one
Sadykov, Ruslan, Vanderbeck, François
openaire   +2 more sources

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