Results 61 to 70 of about 773,474 (304)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Dispariti of prices in the agrarian economy of Russia

open access: yesПутеводитель предпринимателя, 2020
In the basis of the presented analysis of branch features of pricing in agriculture, dynamics of price indices for manufactured goods and agricultural products it is justified that the price parity violation largely determines the current development of ...
N. R. Amirova, L. V. Sargina
doaj  

Research evaluation of mechanical cutting technology of mulberry branch

open access: yesJournal of Hebei University of Science and Technology, 2016
China is the world's largest silkworm cocoon and raw silk producer and exporter. However, as the labor price increases quickly, the sericulture production costs increases, the comparative benefits of sericulture production decreases, and the farmers ...
Zhanhua SONG   +4 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Branch-and-Cut-and-Price algorithms for the preemptive RCPSP [PDF]

open access: yesRAIRO - Operations Research, 2018
In this article, we address the preemptive Resource-Constrained Precedence Scheduling Problem. We propose two mixed integer formulations containing an exponential number of variables and inequalities. An antichain is a set of pairwise incomparable elements with respect to the precedence constraints.
Fouilhoux, Pierre   +3 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

The analysis of price changes transmission along the cereals commodity chain

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2005
The paper aims to analyse the process of the price transmission within selected agri-food chain. First, the issue of the price transmission is introduced as well as the impact of market power on the extent of transmitted price changes in successive ...
Iva Lechanová
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Electronic word of mouth, price, store atmosphere, and brand image on food purchasing decisions

open access: yesReview of Management, Accounting, and Business Studies
This research aims to the culinary business is an activity of producing F&B that aims to be sold to consumers in the hope of getting the maximum possible profit. Kober Mie Setan Branch of Dewi Sri is a well-known culinary business in Bali.
Gede Feby Suarjaya Putra
doaj   +1 more source

Home - About - Disclaimer - Privacy