Results 51 to 60 of about 773,474 (304)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Orphanet Journal of Rare DiseasesBackground Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, disabling genetic disorder condition that lacks real-world evidence on disease burden.
Xiaoyang Xu +7 more
doaj +1 more source
Keunis, 2019 This study aims to determine the significance of marketing mix variables consisting of product, price, promotion, place, people, processe, and physical evidence of BritAma saving decision making at PT Bank Rakyat Indonesia (Persero), Branch of Puri ...
Kinanda Nor Cahya Ningtias +1 more
doaj +1 more source
Finding Minimal Cost Herbrand Models with Branch-Cut-and-Price
, 2018 Given (1) a set of clauses $T$ in some first-order language $\cal L$ and (2) a cost function $c : B_{{\cal L}} \rightarrow \mathbb{R}_{+}$, mapping each ground atom in the Herbrand base $B_{{\cal L}}$ to a non-negative real, then the problem of finding a
Cussens, James
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The rank pricing problem: Models and branch-and-cut algorithms
Computers & Operations Research, 2019 One of the main concerns in management and economic planning is to sell the right product to the right customer for the right price. Companies in retail and manufacturing employ pricing strategies to maximize their revenues. The Rank Pricing Problem considers a unit-demand model with unlimited supply and uniform budgets in which customers have a rank ...
Herminia I. Calvete +4 more
openaire +8 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Gestão & Produção, 2008 This paper presents a proposal for optimizing the public health service in the state of Parana in terms of the flow of patients within the state's boundaries and the regionalization (division) of the state into new hierarchical configurations for this ...
Cassius Tadeu Scarpin +3 more
doaj +1 more source
Branch and Price for a Reliability Oriented DARP Model [PDF]
, 2013 Version 1 - Présentation à ISCO 2014We deal here with a static decisional model related to the monitoring of a DARP (Dial and Ride) model which involves, on a closed industrial site, small electrical autonomous vehicles.
Benoit, Bernay +2 more
core +2 more sources