Results 51 to 60 of about 696,423 (315)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Positivity of Sylow branching coefficients of symmetric groups [PDF]

, 2022
Stacey Law
openalex   +1 more source

Branched Quantization

Physical Review Letters, 2012
We propose a method for quantization of Lagrangians for which the Hamiltonian, as a function of momentum, is a branched function with cusps. Appropriate boundary conditions, which we identify, insure unitary time evolution. In special cases a dual (canonical) transformation maps the problem into a problem of quantum mechanics on singular spatial ...
Shapere, Alfred, Wilczek, Frank
openaire   +5 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Branching into brains [PDF]

eLife, 2017
What can artificial intelligence learn from neuroscience, and vice versa?
Adam Shai, Matthew Evan Larkum
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Variations in the branching pattern of the popliteal artery in the north Karnataka region: A cadaveric study

Indian Journal of Health Sciences and Biomedical Research KLEU
INTRODUCTION: The clinically most important artery of the lower extremities is the popliteal artery. The normal branching pattern of the popliteal artery ranges between 92% and 96%.
Supriya Noveltony, Drakshayini B. Kokati, B. R. Chaitra   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Numerical simulation of gas–liquid two-phase flow in a horizontal manifold with downward branches

Journal of Fluid Science and Technology
Large eddy simulations (LESs) with the volume of fluid (VOF) method are applied to gas–liquid two-phase flows in a horizontal manifold with five downward branches under various inlet flow rates and quality conditions, and the validity is examined by ...
Jun NISHIO, Ryoichi KUROSE
doaj   +1 more source