Results 131 to 140 of about 671,793 (294)

P804: Verification of a software and amplification-based nanopore sequencing solution to characterize complex variants in 11 challenging, high-frequency carrier genes*

Genetics in Medicine Open
John Milligan, Connor Parker, Brennan Greenlee, Juliette Baker, Walairat Wolf, Jon Kemppainen, Justin Janovsky, Jonathan Turner, Christopher Fraher, Monica Roberts, Theodore Markulin, Eduardo Priego, Mahesh Yarasi, Mia Mihailovic, Bryan Killinger, Brian Haynes, Bradley Hall, Ashima Sharma   +17 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

79 Multiplexed detection of RNA and protein to interrogate the tumor-immune landscape with a novel automated RNAscope™ assay

Journal for ImmunoTherapy of Cancer, 2023
Anushka Dikshit, Li-Chong Wang, Ge-Ah Kim, Sonali Deshpande, Maithreyan Srinivasan, Julia Yu, Laetitia Chatelain, Nancy George   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

P585: Amplification-based nanopore sequencing accurately detects HBA and HBB SNVs, indels, and structural variants in clinical thalassemia samples

Genetics in Medicine Open
Jaime Lopes, Marcus Cannon, Jonathan Turner, Monica Roberts, Theodore Markulin, Christopher Fraher, Bryan Killinger, Stela Filipovic-Sadic, Bradley Hall   +8 more
doaj   +1 more source

69 A novel protease-free method for the co-detection of RNA and protein biomarkers using the RNAscope™ technology

Journal for ImmunoTherapy of Cancer, 2023
Steve Zhou, Li-Chong Wang, Ge-Ah Kim, Sonali Deshpande, Maithreyan Srinivasan, Laetitia Chatelain, Nancy George, Anji Bei   +7 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Consumer reactions to self-expressive brand display [PDF]

Brand names and other brand elements are often displayed on one’s body or clothes for the purpose of personal value expression. Despite the frequency of such brand displays in the marketplace, we know little about how consumers respond to seeing brands ...
Raska, David, Czellar, Sandor, Sprott, David E., Spangenberg, Eric R.   +3 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source