Results 51 to 60 of about 68,702 (192)

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

BRCA1 expression in ovarian cancer and its relationship with clinicopathological characteristics and prognosis

Scientific Reports
To investigate the relationship between breast cancer susceptibility 1 (BRCA1) and clinicopathological characteristics and prognosis of ovarian cancer patients.
Chenxiang Pan, Shihao Xu, Lijiao Li, Aidi Lin   +3 more
doaj   +1 more source

The usefulness of antibodies to the BRCA1 protein in detecting the mutated BRCA1 gene. An immunohistochemical study [PDF]

Journal of Clinical Pathology, 2001
To assess the value of immunohistochemistry in discriminating between BRCA1 associated and non-BRCA1 associated breast tumours.Four commercially available anti-BRCA1 antibodies were used on 45 paraffin wax embedded tumoral samples from patients with (seven of 45) and without (38 of 45) BRCA1 germline mutations.
Pérez Vallés, Ana, Martorell Cebolla, Miguel, Nogueira Vázquez, E., García García, José Ángel, Fuster Diana, E.   +4 more
openaire   +3 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

BRCA1 in the DNA damage response and at telomeres

Frontiers in Genetics, 2013
. Mutations of the breast and ovarian cancer susceptibility gene 1 (BRCA1) account for about 40-45% of hereditary breast cancer cases. Moreover, a significant fraction of sporadic (non-hereditary) breast and ovarian cancers exhibit reduced or absent ...
Eliot Michael Rosen
doaj   +1 more source

Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer. [PDF]

PLoS ONE, 2016
Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to harbour varying levels of BRCA1-dysfuction.
Aruna Korlimarla, Jyothi S Prabhu, Jose Remacle, Savitha Rajarajan, Uma Raja, Anupama C E, B S Srinath, Suraj Manjunath, Gopinath K S, Marjorrie Correa, Prasad M S N, T S Sridhar   +11 more
doaj   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells

Cancer Medicine, 2019
BRCA1, a multifunctional protein with an important role in DNA double‐strand break repair by homologous recombination (HR), is subjected to ubiquitin‐dependent degradation.
Qin Lu, Fang‐Lin Zhang, Da‐Yun Lu, Zhi‐Ming Shao, Da-Qiang Li   +4 more
doaj   +1 more source

Supplementary Figure 1 from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

, 2023
Supplementary Figure 1 from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer ...
Tomohiko Ohta, Mamoru Fukuda, Hiromichi Gomi, Ryoko Kojima, Ayaka Koike, Wenwen Wu, Hiroyuki Nishikawa   +6 more
openaire   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source