Results 1 to 10 of about 70 (64)
Current Biology, 2000 Bertwistle D, Ashworth A: Functions of the BRCA1 and BRCA2 genes.Curr Opin Genet Dev 1998, 8:14-20.Rahman N, Stratton MR: The genetics of breast cancer susceptibility.Annu Rev Genet 1998, 32:95-121.Hongbing Z, Tombline G, Weber BL: BRCA1, BRCA2, and DNA damage response: collision or collusion?Cell 1998, 92:433-436.
Bertwistle, David, Ashworth, Alan
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International Journal of Biological Sciences, 2021 Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling, transcriptional regulation, as well as R ...
Yang, Jing +5 more
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Cancer Biology & Therapy, 2004 The BRCA1 tumor suppressor gene is expressed in all mammalian cells. Within these cells, the BRCA1 protein product interacts with several seemingly distinct nuclear complexes. Proteins within these complexes are potential targets for the E3-ubiquitin ligase activity associated with BRCA1:BARD1 complexes.
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European Journal of Human Genetics, 2004 Two recent papers suggest distorted sex and transmission ratios associated with BRCA1 mutations. If real, these would provide novel insights into the normal biological function of this gene and have implications for genetic epidemiologic methods used to estimate penetrance.
Jeffery P, Struewing +4 more
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BRCA1 and cell signaling [PDF]
Oncogene, 2000 The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA
Q, Wang +3 more
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BRCA1 and Oxidative Stress [PDF]
Cancers, 2014 The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing ...
Yi, Yong Weon, Kang, Hyo Jin, Bae, Insoo
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BRCA1 A-Complex fine tunes repair functions of BRCA1
Aging, 2011 Germline mutations in BRCA1 increase the risk of breast and ovarian cancer, but the specific pathways driving breast and ovarian cancer development in BRCA1 mutants are currently unclear [1]. Several studies have demonstrated that BRCA1 is required for cellular responses to DNA double strand breaks (DSBs) and homologous recombination (HR), although its
Janelle L, Harris, Kum Kum, Khanna
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BRCA1-Mediated Ubiquitylation [PDF]
Cell Cycle, 2006 The BRCA1 tumour suppressor and its heterodimeric partner BARD1 play crucial roles in coordinating cellular responses to DNA damage. Evidence also implicates these proteins in transcriptional regulation, cell cycle progression and meiotic sex chromosome inactivation, but their mode of action remains elusive.
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Transcriptional Autoregulation by BRCA1 [PDF]
Cancer Research, 2010 Abstract The BRCA1 gene product plays numerous roles in regulating genome integrity. Its role in assembling supermolecular complexes in response to DNA damage has been extensively studied; however, much less is understood about its role as a transcriptional coregulator. Loss or mutation is associated with hereditary breast and ovarian
de Siervi, Adriana +9 more
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Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1 [PDF]
Oncogene, 2001 Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins.
S, Fan +5 more
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