Results 1 to 10 of about 74,972 (273)

Regulation of BRCA1 by protein degradation [PDF]

Oncogene, 1999
BRCA1, a tumor suppressor protein implicated in hereditary forms of breast and ovarian cancer, is transcriptionally regulated in a proliferation-dependent manner. In this study, we demonstrate a substantial role for proteolysis in regulating the BRCA1 steady-state protein level in several cell lines. N-acetyl-leu-leu-norleucinal (ALLN), an inhibitor of
M V Blagosklonny, Won G An, Giovanni Melillo   +2 more
exaly   +3 more sources

BRCA1/2 Reversion Mutations and Cancer Therapy Resistance [PDF]

Biology
Germline loss-of-function mutations in BRCA1 and BRCA2 markedly increase susceptibility to breast, ovarian, and other cancers. Mechanistically, BRCA2 facilitates RAD51 recruitment to sites of DNA damage, whereas BRCA1 regulates homologous recombination ...
Wenjing Qi, Gege Yang, Yingyi Zhang, Liping Han, Kevin H. Mayo, Xianlu Zeng, Jingang Mo   +6 more
doaj   +2 more sources

Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. [PDF]

PLoS ONE, 2010
Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling ...
Irene Guendel, Lawrence Carpio, Caitlin Pedati, Arnold Schwartz, Christine Teal, Fatah Kashanchi, Kylene Kehn-Hall   +6 more
doaj   +2 more sources

BRCA1 protein dose-dependent risk for embryonic oxidative DNA damage, embryopathies and neurodevelopmental disorders with and without ethanol exposure [PDF]

Redox Biology
Although widely known as a tumor suppressor, the breast cancer 1 susceptibility protein (BRCA1) is also important in development, where it regulates fetal DNA repair pathways that protect against DNA damage caused by physiological and drug-enhanced ...
Danielle M. Drake, Kian Afsharian, Benjamin Or, Aaron M. Shapiro, Michelle L. Lai, Lutfiya Miller, Peter G. Wells   +6 more
doaj   +2 more sources

Heteroduplex and protein truncation analysis of the BRCA1 185delAG mutation [PDF]

Human Genetics, 1996
We describe a heteroduplex analysis for the detection of the 185delAG mutation in the BRCA1 gene. The protein truncation test (PTT) has previously been used to identify many of the mutations in BRCA1 that result in premature termination of the protein.
Hilmi Özçelik, D E Cole, Irène L Andrulis   +2 more
exaly   +3 more sources

Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers

Cell Reports
Summary: Predicting the risk of cancer mutations is critical for early detection and prevention, but differences in allelic severity of human carriers confound risk predictions.
Brant Gracia, Patricia Montes, Angelica Maria Gutierrez, Banu Arun, Georgios Ioannis Karras   +4 more
doaj   +3 more sources

BAP1: Not just a BRCA1-associated protein [PDF]

Cancer Treatment Reviews, 2020
BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response.
Louie, Bryan H, Kurzrock, Razelle
openaire   +3 more sources

BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

iScience, 2022
Summary: Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks.
Robert Hromas, Gayathri Srinivasan, Ming Yang, Aruna Jaiswal, Taylor A. Totterdale, Linda Phillips, Austin Kirby, Nazli Khodayari, Mark Brantley, Elizabeth A. Williamson, Kimi Y. Kong   +10 more
doaj   +1 more source

BRCA1-Dependent Translational Regulation in Breast Cancer Cells. [PDF]

PLoS ONE, 2013
BRCA1 (Breast Cancer 1) has been implicated in a number of cellular processes, including transcription regulation, DNA damage repair and protein ubiquitination.
Estelle Dacheux, Anne Vincent, Nicolas Nazaret, Christophe Combet, Anne Wierinckx, Sylvie Mazoyer, Jean-Jacques Diaz, Joël Lachuer, Nicole Dalla Venezia   +8 more
doaj   +1 more source

Abnormal expression of BRCA1 and BRCA1‐interactive DNA‐repair proteins in breast carcinomas [PDF]

International Journal of Cancer, 2000
Breast cancer is one of the most common malignancies among women. The molecular mechanisms involved in breast carcinogenesis, however, remain to be elucidated. Although somatic mutation of BRCA1 is rare, BRCA1 protein expression is reduced in about 30% of sporadic breast carcinomas (Yoshikawa et al., Clin.
K, Yoshikawa, T, Ogawa, R, Baer, H, Hemmi, K, Honda, A, Yamauchi, T, Inamoto, K, Ko, S, Yazumi, H, Motoda, H, Kodama, S, Noguchi, A F, Gazdar, Y, Yamaoka, R, Takahashi   +14 more
openaire   +2 more sources