Results 11 to 20 of about 74,972 (273)

In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein

Breast Cancer: Basic and Clinical Research, 2011
BRCA1 is a tumor suppressor protein involved in maintaining genomic integrity through multiple functions in DNA damage repair, transcriptional regulation, cell cycle checkpoint, and protein ubiquitination. The BRCA1-BARD1 RING complex has an E3 ubiquitin
Apichart Atipairin, Adisorn Ratanaphan
doaj   +2 more sources

Rapid detection of BRCA1 mutations by the protein truncation test [PDF]

Nature Genetics, 1995
More than 75% of the reported mutations in the hereditary breast and ovarian cancer gene, BRCA1, result in truncated proteins. We have used the protein truncation test (PTT) to screen for mutations in exon 11, which encodes 61% of BRCA1. In 45 patients from breast and/or ovarian cancer families we found six novel mutations: two single nucleotide ...
Hogervorst, FBL, Cornelis, RS, Bout, M, van Vliet, M, Oosterwijk, JC, Olmer, R, Bakker, B, Klijn, JGM, Vasen, HFA, Meijers Heijboer, H, Menko, FH, Cornelisse, CJ, den Dunnen, JT, Devilee, P, van Ommen, GJB   +14 more
core   +8 more sources

The usefulness of antibodies to the BRCA1 protein in detecting the mutated BRCA1 gene. An immunohistochemical study [PDF]

Journal of Clinical Pathology, 2001
Aim —To assess the value of immunohistochemistry in discriminating between BRCA1 associated and non-BRCA1 associated breast tumours. Methods —Four commercially available anti-BRCA1 antibodies were used on 45 paraffin wax embedded ...
Pérez Vallés, Ana, Martorell Cebolla, Miguel, Nogueira Vázquez, E., García García, José Ángel, Fuster Diana, E.   +4 more
openaire   +5 more sources

Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. [PDF]

Cell Death Differ, 2019
Cathepsin S (CTSS) is a cysteine protease that is thought to play a role in many physiological and pathological processes including tumor growth, angiogenesis, and metastasis; it has been identified as a radiation response gene.
Kim S, Jin H, Seo HR, Lee HJ, Lee YS.
europepmc   +2 more sources

Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation

Redox Biology, 2021
The breast cancer 1 protein (BRCA1) facilitates DNA repair, preventing embryolethality and protecting the fetus from reactive oxygen species (ROS)-induced developmental disorders mediated by oxidatively damaged DNA.
Danielle M. Drake, Peter G. Wells
doaj   +1 more source

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

Cell Reports, 2021
Summary: The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous ...
Elizabeth V. Minten, Priya Kapoor-Vazirani, Chunyang Li, Hui Zhang, Kamakshi Balakrishnan, David S. Yu   +5 more
doaj   +1 more source

BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity [PDF]

Cancer Research, 2008
Abstract The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that bound to the RING finger domain of BRCA1.
Hiroyuki, Nishikawa, Wenwen, Wu, Ayaka, Koike, Ryoko, Kojima, Hiromichi, Gomi, Mamoru, Fukuda, Tomohiko, Ohta   +6 more
openaire   +2 more sources

BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
core   +1 more source

BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. [PDF]

PLoS ONE, 2009
BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta)
Huchun Li, Masayuki Sekine, Seyha Seng, Shalom Avraham, Hava Karsenty Avraham   +4 more
doaj   +1 more source

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough

Frontiers in Pharmacology, 2022
BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu, Thiago T. Gomes, Thales C. Nepomuceno, Thales C. Nepomuceno, Xueli Li, Mateus Fuchshuber-Moraes, Giuliana De Gregoriis, Guilherme Suarez-Kurtz, Alvaro N. A. Monteiro, Marcelo A. Carvalho, Marcelo A. Carvalho   +10 more
doaj   +1 more source