Results 11 to 20 of about 73,095 (214)
Molecular Cancer, 2009 Background DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure.
Walsh Tom +6 more
doaj +1 more source
BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer [PDF]
Archives of Biological Sciences, 2013 We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression.
Mitrović Olivera +7 more
doaj +1 more source
In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein
Breast Cancer: Basic and Clinical Research, 2011 BRCA1 is a tumor suppressor protein involved in maintaining genomic integrity through multiple functions in DNA damage repair, transcriptional regulation, cell cycle checkpoint, and protein ubiquitination. The BRCA1-BARD1 RING complex has an E3 ubiquitin
Apichart Atipairin, Adisorn Ratanaphan
doaj +1 more source
Structure-Function Of The Tumor Suppressor BRCA1
Computational and Structural Biotechnology Journal, 2012 BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain.
Serena L. Clark +4 more
doaj +3 more sources
Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao +7 more
doaj +1 more source
RNA Biology, 2023 Breast Cancer Gene 1 (BRCA1) is a tumour suppressor protein that modulates multiple biological processes including genomic stability and DNA damage repair.
Panagiotis G. Adamopoulos +6 more
doaj +1 more source
BRCA1 and Its Network of Interacting Partners
Biology, 2013 BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated lifetime risk of 60%–80% for breast cancer and 15%–60% for ...
Kyriacos Kyriacou, Charita M. Christou
doaj +1 more source
ZNF121 interacts with ZBRK1 and BRCA1 to regulate their target genes in mammary epithelial cells
FEBS Open Bio, 2018 The novel zinc finger protein 121 (ZNF121) has been demonstrated to physically and functionally associate with the MYC oncoprotein to regulate cell proliferation and likely breast cancer development.
Ang Luo +5 more
doaj +1 more source
Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1
Cells, 2020 BRCA1 inactivation is a hallmark of familial breast cancer, often associated with aggressive triple negative breast cancers. BRCA1 is a tumor suppressor with known functions in DNA repair, transcription regulation, cell cycle control, and apoptosis.
Elise Berthel +13 more
doaj +1 more source
iScienceSummary: PARP inhibitors (PARPi) are efficacious in BRCA1-null tumors; however, their utility is limited in tumors with functional BRCA1. We hypothesized that pharmacologically reducing BRCA1 protein levels could enhance PARPi effectiveness in BRCA1 wild-
Erin Sellars +11 more
doaj +1 more source