Rapid Evolution of BRCA1 and BRCA2 in Humans and Other Primates [PDF]
, 2014 The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA.
Demogines, Ann M. +6 more
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BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer [PDF]
Archives of Biological Sciences, 2013 We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression.
Mitrović Olivera +7 more
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The PARP-1 inhibitor Olaparib causes retention of γ-H2AX foci in BRCA1 heterozygote cells following exposure to gamma radiation [PDF]
, 2013 This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 Emma C. Bourton et al. This is an open access article distributed under the Creative Commons Attribution Li-cense, which permits unrestricted use ...
Adam Zahir, S +4 more
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Molecular Cancer, 2009 Background DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure.
Walsh Tom +6 more
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DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial. [PDF]
, 2017 Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature.
Berry, Don +20 more
core +2 more sources
Structure-Function Of The Tumor Suppressor BRCA1
Computational and Structural Biotechnology Journal, 2012 BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain.
Serena L. Clark +4 more
doaj +3 more sources
PALB2 self-interaction controls homologous recombination. [PDF]
, 2012 PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
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Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao +7 more
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An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]
, 2014 Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan +2 more
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In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein
Breast Cancer: Basic and Clinical Research, 2011 BRCA1 is a tumor suppressor protein involved in maintaining genomic integrity through multiple functions in DNA damage repair, transcriptional regulation, cell cycle checkpoint, and protein ubiquitination. The BRCA1-BARD1 RING complex has an E3 ubiquitin
Apichart Atipairin, Adisorn Ratanaphan
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