Results 41 to 50 of about 177,994 (348)
Cancer Biology & Therapy, 2004 The BRCA1 tumor suppressor gene is expressed in all mammalian cells. Within these cells, the BRCA1 protein product interacts with several seemingly distinct nuclear complexes. Proteins within these complexes are potential targets for the E3-ubiquitin ligase activity associated with BRCA1:BARD1 complexes.
openaire +2 more sources
BRCA1 and BRCA2 and Inherited Predisposition to Breast and Ovarian Cancers
McGill Journal of Medicine, 2002 N ...
Patricia N. Tonin
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Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao +7 more
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PALB2 self-interaction controls homologous recombination. [PDF]
, 2012 PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
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Guideline-Based, Multi-Gene Panel Germline Genetic Testing for at-Risk Patients with Breast Cancer
Breast Cancer: Targets and Therapy, 2023 Hikmat Abdel-Razeq,1,2 Lama Abujamous,3 Khansa Al-Azzam,1 Hala Abu-Fares,1 Hira Bani Hani,1 Mais Alkyam,1 Baha’ Sharaf,1 Shatha Elemian,1 Faris Tamimi,1 Fawzi Abuhijla,4 Sarah Edaily,1 Osama Salama,1 Hazem Abdulelah,1 Rand Daoud,1 Mohammad Abubaker,1 ...
Abdel-Razeq H +15 more
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A systematic review on the association between ovarian and prostate cancer with BRCA1 and BRCA2 gene
Сибирский онкологический журнал, 2023 Background. BRCA1 and BRCA2 were discussed as the basis of inherited adenocarcinoma and breast and ovarian malignancy. Ovarian cancer is uncommon in women below 40 years of age, and prostate cancer mainly occurs in older men cause 90 % in those above ...
Sarpparajan Chitra Veena +2 more
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Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2022 Введение. Овариальные карциномы – сложное гетерогенное заболевание с разнообразием клинико-морфологических форм. В большинстве случаев опухоли яичников экспрессируют эстрогеновые (РЭ), прогестероновые (РП) или андрогеновые (РА) рецепторы, но, в отличие ...
А. L. Savаnevich +2 more
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The impact of known breast cancer polygenes on critical illness insurance [PDF]
, 2015 Genetic studies indicate that the inherited risk of breast cancer is mediated by the well-studied major genes BRCA1 and BRCA2, and a polygenic component, probably with many genes each making a small contribution. Recently, seven polygenes have been found
Adams, Craig +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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BRCA1/2 associated cancer susceptibility: a clinical overview
Forum of Clinical Oncology, 2016 The most frequently identified genetic cause of breast cancer is the germline mutation of BRCA1 and 2 genes. The carriers of these mutations are at high risk for breast and ovarian cancers and increased risk for pancreatic and prostate cancers.
Lypas Georgios
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