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Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses [PDF]
PeerJ, 2020 Background BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated.
Yue Li +8 more
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Frontiers in Oncology, 2021 Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of breast and ovarian cancer is higher than in the general population.
Gabriella Doddato +72 more
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Clinicopathological characteristics of -associated breast cancer in Asian patients [PDF]
Journal of Pathology and Translational Medicine, 2020 BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison
Eun-Kyu Kim, So Yeon Park, Sung-Won Kim
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Biomédica: revista del Instituto Nacional de Salud, 2021 Introduction: Next Generation Sequencing (NGS) is cost-effective and a faster method to study genes, but its protocol is challenging. Objective: To analyze different adjustments to the protocol for screening the BRCA genes using Ion Torrent PGM ...
Tiago César Gouvêa Moreira +6 more
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Complex Regulation of the BRCA1 Gene [PDF]
Journal of Biological Chemistry, 1997 We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi ...
C F, Xu, J A, Chambers, E, Solomon
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Biomedical and Biotechnology Research Journal, 2022 Background: Hereditary breast cancers constitute around 5%–10% of all breast cancers. The most commonly mutated genes in hereditary breast and ovarian cancer syndrome are the BRCA1 and BRCA2 genes.
Reeba Mary Issac +6 more
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Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1 [PDF]
Oncogene, 2001 Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins.
S, Fan +5 more
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BRCA1 Represses Amphiregulin Gene Expression [PDF]
Cancer Research, 2010 Abstract BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes ...
Ekaterina P, Lamber +2 more
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European Journal of Breast Health, 2021 Objective:BRCA1/2 genes play a role in the etiopathogenesis of 10%–30% of triple-negative breast cancer (TNBC). This study aims to investigate the BRCA1/2 genes and the demographic and clinicopathological features in patients with TNBC.
Neslihan Duzkale, Olcay Kandemir
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BRCA1 gene in breast cancer [PDF]
Journal of Cellular Physiology, 2003 AbstractThe BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of BRCA1 are responsible for about 40–45% of hereditary breast cancers, these mutations account for only 2‐3% of all breast cancers, since the BRCA1 gene is rarely mutated in ...
Eliot M, Rosen +3 more
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