Results 1 to 10 of about 115,160 (161)

The Effects of BRCA1 and BRCA2 Promoter Methylation on Clinicopathological Characteristics and Clinical Outcomes in HGSOC [PDF]

Cells
Ovarian cancer is a highly lethal disease. Tumors with a deficiency in the homologous recombination repair pathway (HRD) resulting from mutations in BRCA1/2 genes have a favorable response to platinum-based chemotherapy and targeted therapy with PARP ...
Katarina Živić, Ivana Boljević, Milica Nedeljković, Milana Matović, Radmila Janković, Miljana Tanić   +5 more
doaj   +2 more sources

Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses [PDF]

PeerJ, 2020
Background BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated.
Yue Li, Xiaoyan Zhou, Jiali Liu, Yang Yin, Xiaohong Yuan, Ruihua Yang, Qi Wang, Jing Ji, Qian He   +8 more
doaj   +2 more sources

Exome Sequencing in BRCA1-2 Candidate Familias: The Contribution of Other Cancer Susceptibility Genes

Frontiers in Oncology, 2021
Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of breast and ovarian cancer is higher than in the general population.
Gabriella Doddato, Gabriella Doddato, Floriana Valentino, Floriana Valentino, Annarita Giliberti, Annarita Giliberti, Filomena Tiziana Papa, Filomena Tiziana Papa, Rossella Tita, Lucia Pia Bruno, Lucia Pia Bruno, Sara Resciniti, Sara Resciniti, Chiara Fallerini, Chiara Fallerini, Elisa Benetti, Maria Palmieri, Maria Palmieri, Maria Antonietta Mencarelli, Alessandra Fabbiani, Alessandra Fabbiani, Alessandra Fabbiani, Mirella Bruttini, Mirella Bruttini, Alfredo Orrico, Margherita Baldassarri, Margherita Baldassarri, Francesca Fava, Francesca Fava, Francesca Fava, Diego Lopergolo, Diego Lopergolo, Diego Lopergolo, Caterina Lo Rizzo, Vittoria Lamacchia, Vittoria Lamacchia, Vittoria Lamacchia, Sara Mannucci, Sara Mannucci, Sara Mannucci, Anna Maria Pinto, Aurora Currò, Aurora Currò, Aurora Currò, Virginia Mancini, Oncologic Multidisciplinary Team, Azienda Ospedaliera Universitaria Senese, Oncologic Multidisciplinary Team, Azienda Usl Toscana Sud Est, Francesca Mari, Francesca Mari, Francesca Mari, Alessandra Renieri, Alessandra Renieri, Alessandra Renieri, Francesca Ariani, Francesca Ariani, Francesca Ariani, Alessandro Neri, Donato Casella, Andrea Bernini, Stefania Marsili, Roberto Petrioli, Salvatora Tindara Miano, Alessandra Pascucci, Ignazio Martellucci, Monica Crociani, Marta Vannini, Federica Fantozzi, Andrea Stella, Alessia Carmela Tripodi, Angelamaria Giusti, Alfonso Fausto, Lucia Mantovani, Francesca Belardi   +72 more
doaj   +1 more source

Clinicopathological characteristics of -associated breast cancer in Asian patients [PDF]

Journal of Pathology and Translational Medicine, 2020
BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison
Eun-Kyu Kim, So Yeon Park, Sung-Won Kim
doaj   +1 more source

Correlation between the number of false positive variants and the quality of results using Ion Torrent PGM™ sequencing to screen BRCA genes

Biomédica: revista del Instituto Nacional de Salud, 2021
Introduction: Next Generation Sequencing (NGS) is cost-effective and a faster method to study genes, but its protocol is challenging. Objective: To analyze different adjustments to the protocol for screening the BRCA genes using Ion Torrent PGM ...
Tiago César Gouvêa Moreira, Pricila da Silva Spínola, Micheline Campos Rezende, Carla Simone Moreira de Freitas, Fábio Borges Mury, Cibele Rodrigues Bonvicino, Luciana de Andrade Agostinho   +6 more
doaj   +1 more source

Histopathological characterization of carcinoma breast with BRCA1/2 sequence variation in a Tertiary Care Center in Kerala, South India

Biomedical and Biotechnology Research Journal, 2022
Background: Hereditary breast cancers constitute around 5%–10% of all breast cancers. The most commonly mutated genes in hereditary breast and ovarian cancer syndrome are the BRCA1 and BRCA2 genes.
Reeba Mary Issac, Prema Saldanha, Jessy Mangalathu Mathai, Jency Mathews, Rebecca Mathews, Bindu Kumari, Tiju Chacko   +6 more
doaj   +1 more source

The Relationship of Mutation Carriage of BRCA1/2 and Family History in Triple-Negative Breast Cancer: Experience from a Diagnostic Center in Turkey

European Journal of Breast Health, 2021
Objective:BRCA1/2 genes play a role in the etiopathogenesis of 10%–30% of triple-negative breast cancer (TNBC). This study aims to investigate the BRCA1/2 genes and the demographic and clinicopathological features in patients with TNBC.
Neslihan Duzkale, Olcay Kandemir
doaj   +1 more source

BRCA1-mediated repression of select X chromosome genes

Journal of Translational Medicine, 2004
Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated.
Ropers H Hilger, Liu Edison T, Nuber Ulrike A, Sotiriou Christos, Aprelikova Olga, Chandramouli Gadisetti VR, Jazaeri Amir A, Yee Cindy J, Boyd Jeff, Barrett J Carl   +9 more
doaj   +1 more source

Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma [PDF]

, 2017
High-grade epithelial ovarian carcinomas (OC) containing mutated BRCA1 or BRCA2 (BRCA1/2) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi), while restoration of HR ...
Barker, Holly, Bernstein, Kara A., Botwell, David D.L., Brunette, Gregory J., Coleman, Robert L., Floquet, Anna, Friedlander, Michael, Giordano, Heidi, Harding, Thomas C., Harrell, Maria I., Ho, Gwo-Yaw, Jasin, Maria, Kass, Elizabeth M., Kaufmann, Scott H., Kichenadasse, Ganessan, Kondrashova, Olga, Kuiper, Michael J., Lin, Kevin K., Maloney, Lara, McNeish, Iain A., Nguyen, Minh, O'Malley, David M., Oza, Amit M., Prakash, Rohit, Raponi, Mitch, Robillard, Liliane, Scott, Clare L., Shield-Artin, Kirsty, Simmons, Andrew D., Sullivan, Meghan R., Sun, James X., Swisher, Elizabeth M., Teng, Nelson N.H., Tinker, Anna V., Wakefield, Matthew J.   +34 more
core   +1 more source

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. [PDF]

, 2017
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress.
Angel Pujana, Miguel, Brunet, Joan, Chaldekas, Krysta, Chedin, Frederic, Chiang, Huai-Chin, Curiel, Tyler J, Elledge, Richard, Hu, Yanfen, Isaacs, Claudine, Jatoi, Ismail, Jin, Victor X, Lautner, Meeghan, Li, Rong, Mateo, Francesca, Michalek, Joel, Nair, Sreejith J, Ochoa, Oscar, Oliver, Boyce, Peshkin, Beth N, Petit, Anna, Poggi, Elizabeth, Smith, Sabrina, Soler, Teresa, Sun, Lu-Zhe, Theoharis, Constantine, Wang, Howard, Wang, Yao, Zhang, Chi, Zhang, Xiaowen, Zhao, Xiayan   +29 more
core   +2 more sources