Results 11 to 20 of about 115,309 (309)

Complex Regulation of the BRCA1 Gene [PDF]

Journal of Biological Chemistry, 1997
We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi ...
C F, Xu, J A, Chambers, E, Solomon
openaire   +2 more sources

Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1 [PDF]

Oncogene, 2001
Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins.
S, Fan, R, Yuan, Y X, Ma, Q, Meng, I D, Goldberg, E M, Rosen   +5 more
openaire   +2 more sources

BRCA1 Represses Amphiregulin Gene Expression [PDF]

Cancer Research, 2010
Abstract BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes ...
Ekaterina P, Lamber, Andrew A, Horwitz, Jeffrey D, Parvin   +2 more
openaire   +2 more sources

BRCA1 gene in breast cancer [PDF]

Journal of Cellular Physiology, 2003
AbstractThe BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of BRCA1 are responsible for about 40–45% of hereditary breast cancers, these mutations account for only 2‐3% of all breast cancers, since the BRCA1 gene is rarely mutated in ...
Eliot M, Rosen, Saijun, Fan, Richard G, Pestell, Itzhak D, Goldberg   +3 more
openaire   +2 more sources

BRCA1 and BRCA2 genes mutations among women with clinical signs of hereditary breast cancer in western Belarus

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021
Background: Breast cancer is the most common malignancy in women. In the countries of Central and Eastern Europe founder mutations in the BRCA1 and BRCA2 genes are responsible for a significant proportion of breast cancer cases; however, regional ...
Alena Savanevich, Maryia Vasilkevich, Vitalii Abdrashitov, Tatiana Stepuro   +3 more
doaj   +1 more source

Rapid Evolution of BRCA1 and BRCA2 in Humans and Other Primates [PDF]

, 2014
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA.
Demogines, Ann M., Le, Uyen Q., Lou, Dianne I., McBee, Ross M., Sawyer, Sara L., Stone, Anne C., Wilkerson, Gregory K.   +6 more
core   +3 more sources

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
core   +1 more source

Characterization of genetic predisposition to molecular subtypes of breast cancer in Brazilian patients

Frontiers in Oncology, 2022
IntroductionBRCA1 and BRCA2 germline pathogenic variants (GPVs) account for most of the 5-10% of breast cancer (BC) that is attributable to inherited genetic variants.
Daniele Paixão, Giovana Tardin Torrezan, Giovana Tardin Torrezan, Karina Miranda Santiago, Maria Nirvana Formiga, Samuel Terkper Ahuno, Emmanuel Dias-Neto, Emmanuel Dias-Neto, Israel Tojal da Silva, Israel Tojal da Silva, William D. Foulkes, Paz Polak, Dirce Maria Carraro, Dirce Maria Carraro   +13 more
doaj   +1 more source

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]

, 2014
BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Abdel-Fatah, TMA, Agarwal, D, Albarakati, N, Alsubhi, N, Arora, A, Ball, G, Caldas, C, Chan, S, Doherty, R, Ellis, IO, Green, A, Madhusudan, S, Moseley, P, Perry, C, Rakha, EA, Russell, R, Seedhouse, C   +16 more
core   +1 more source

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Biological Research, 2017
Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes.
Lilian Jara, Sebastian Morales, Tomas de Mayo, Patricio Gonzalez-Hormazabal, Valentina Carrasco, Raul Godoy   +5 more
doaj   +1 more source