Results 11 to 20 of about 1,685,955 (199)

A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. [PDF]

open access: yes, 2002
In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purposes, it is important to allow for the fact that other breast cancer susceptibility genes may exist.
P D P Pharoah   +15 more
core   +1 more source

Characterization of genetic predisposition to molecular subtypes of breast cancer in Brazilian patients

open access: yesFrontiers in Oncology, 2022
IntroductionBRCA1 and BRCA2 germline pathogenic variants (GPVs) account for most of the 5-10% of breast cancer (BC) that is attributable to inherited genetic variants.
Daniele Paixão   +13 more
doaj   +1 more source

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer [PDF]

open access: yes, 2001
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast ...
Bruce AJ Ponder   +13 more
core   +2 more sources

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

open access: yesBiological Research, 2017
Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes.
Lilian Jara   +5 more
doaj   +1 more source

BRCA1 and BRCA2 genes mutations among women with clinical signs of hereditary breast cancer in western Belarus

open access: yesJournal of V. N. Karazin Kharkiv National University: Series Medicine, 2021
Background: Breast cancer is the most common malignancy in women. In the countries of Central and Eastern Europe founder mutations in the BRCA1 and BRCA2 genes are responsible for a significant proportion of breast cancer cases; however, regional ...
Alena Savanevich   +3 more
doaj   +1 more source

Hypersensitivity of BRCA1 heterozygote lymphoblastoid cells to gamma radiation and PARP inhibitors [PDF]

open access: yes, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Bourton EC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use ...
Bourton, EC   +5 more
core   +1 more source

Genomic landscape of advanced prostate cancer patients with BRCA1 versus BRCA2 mutations as detected by comprehensive genomic profiling of cell-free DNA

open access: yesFrontiers in Oncology, 2022
BRCA1-mutated prostate cancer has been shown to be less responsive to poly (ADP-ribose) polymerase (PARP) inhibitors as compared to BRCA2-mutated prostate cancer. The reason for this differential response is not clear.
Umang Swami   +20 more
doaj   +1 more source

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers [PDF]

open access: yes, 2006
BackgroundThe MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in ...
Johnson, Peter W.   +17 more
core   +2 more sources

Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish Mutation Carriers in High Risk Breast Cancer Families

open access: yesCancer Informatics, 2009
Mutations in two major genes, BRCA1 and BRCA2 , account for up to 30% of families with hereditary breast cancer. Unfortunately, in most families there is little to indicate which gene should be targeted first for mutation screening, which is labor ...
Marie-Laure Vuillaume   +7 more
doaj   +1 more source

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 [PDF]

open access: yes, 2011
The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...
Donaldson, A.   +999 more
core   +6 more sources

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