Results 21 to 30 of about 1,685,955 (199)

Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data

Breast Cancer: Basic and Clinical Research, 2023
Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2 )-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs.
Maher Albitar, Hong Zhang, Andrew Pecora, Stanley Waintraub, Deena Graham, Mira Hellmann, Donna McNamara, Ahmad Charifa, Ivan De Dios, Wanlong Ma, Andre Goy   +10 more
doaj   +1 more source

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

Open Biology, 2021
RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans.
Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood   +11 more
doaj   +1 more source

Relationship between DNA damage response and telomere maintenance [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are regions of repetitive DNA bound with a set of specialized proteins required to protect chromosomes from fusing with each other and from ...
Ojani, Maryam
core   +7 more sources

Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer [PDF]

Journal of Liaquat National Hospital
Breast cancer is a complex disease characterized by a myriad of genetic alterations. Single nucleotide polymorphisms are particularly relevant due to small allelic variations.
Saba Munir, Yasir Nawaz, Fouzia Tanvir, Maria Akram, Muhammad Luqman, Javaria Zafar, Muhammad Zaman   +6 more
doaj   +1 more source

Germline sequence variants contributing to cancer susceptibility in South African breast cancer patients of African ancestry

Scientific Reports, 2022
Since the discovery of the breast cancer susceptibility genes, BRCA1 and BRCA2, various other genes conferring an increased risk for breast cancer have been identified.
Dewald Eygelaar, Elizabeth J. van Rensburg, Fourie Joubert   +2 more
doaj   +1 more source

Sequence Variants of BRCA1 and BRCA2 Genes in Four Iranian Families with Breast and Ovarian Cancer [PDF]

Iranian Journal of Public Health, 2011
Background: BRCA1 and BRCA2 genes have been recognized to be responsible for 20-30% of hereditary breast can­cers and approximately 50% of familial breast and ovarian cancers.
F Keshavarzi, A Eskafi Noughani, MH Ayoubian, S Zeinali   +3 more
doaj   +1 more source

Investigation of the relationship of TNFRSF11A gene polymorphisms with breast cancer development and metastasis risk in patients with BRCA1 or BRCA2 pathogenic variants living in the Trakya region of Turkey

Balkan Journal of Medical Genetics, 2021
Modifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of BRCA1 or BRCA2.
Özdemir K, Gürkan H, Demir S, Atli E, Özen Y, Sezer A, Tunçbilek N, Çicin İ   +7 more
doaj   +1 more source

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors

BMC Cancer, 2007
Background The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the ubiquitination of proteins; however its precise functions remain to be fully understood ...
Pinnaduwage Dushanthi, Bosnoyan-Collins Lucine, Winter Sherry L, Andrulis Irene L   +3 more
doaj   +1 more source

BRCA1 mutation influences progesterone response in human benign mammary organoids

Breast Cancer Research, 2019
Background Women, who carry a germline BRCA1 gene mutation, have a markedly increased risk of developing breast cancer during their lifetime. While BRCA1 carriers frequently develop triple-negative, basal-like, aggressive breast tumors, hormone signaling
Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E. Clare, Seema A. Khan, J. Julie Kim   +5 more
doaj   +1 more source

Determination of BRCA1 and BRCA2 Gene Mutations in Patients at Risk of Breast and/or Ovarian Cancer by Next Generation Sequencing in the Isparta Region

Batı Karadeniz Tıp Dergisi, 2021
and/or ovarian cancers. BRCA1 / BRCA2 genes are associated with 20-25% of these diseases. Thespectrum and prevalence of BRCA1 and BRCA2 gene mutations are different in each population.Determining the prevalence of pathogenic mutations in susceptibility ...
Muhammet Yusuf Tepebaşı, Kuyaş Hekimler Öztürk, Halil Özbaş, Pinar Aslan Kosar   +3 more
doaj   +1 more source