Results 21 to 30 of about 115,309 (309)

Transactivation of Repair Genes by BRCA1 [PDF]

Cancer Biology & Therapy, 2002
Recent studies have identified a link between the BRCA1 tumor suppressor and transcriptional regulation of a group of genes involved in nucleotide excision repair. There is some controversy regarding the precise mechanism of upregulation of XPE DDB2 or XPC by BRCA1, with some evidence suggesting that p53 is involved in their regulation.
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Regulation of the BRCA1 gene by an SRC3/53BP1 complex [PDF]

BMC Biochemistry, 2011
Abstract Background Steroid Receptor coactivator 3(SRC3) is an oncogene and a member of the SRC family of nuclear receptor coactivator proteins that mediate the transcriptional effects of nuclear hormone receptors as well as other transcription factors.
Corkery, Dale, Thillainadesan, Gobi, Coughlan, Niamh, Mohan, Ryan D., Isovic, Majdina, Tini, Marc, Torchia, Joseph   +6 more
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Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer [PDF]

, 2002
BACKGROUND: Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified
Dalton, Ann, Harirchi, Iraj, Hornby, David P., Jarvandi, Soghra, Mohagheghi, Mohammad A., Yassaee, Vahid R., Zeinali, Sirous   +6 more
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Genomic landscape of advanced prostate cancer patients with BRCA1 versus BRCA2 mutations as detected by comprehensive genomic profiling of cell-free DNA

Frontiers in Oncology, 2022
BRCA1-mutated prostate cancer has been shown to be less responsive to poly (ADP-ribose) polymerase (PARP) inhibitors as compared to BRCA2-mutated prostate cancer. The reason for this differential response is not clear.
Umang Swami, Raquel Mae Zimmerman, Roberto H. Nussenzveig, Edgar Javier Hernandez, Yeonjung Jo, Nicolas Sayegh, Sergiusz Wesolowski, Lesli A. Kiedrowski, Pedro C. Barata, Gordon Howard Lemmon, Mehmet A. Bilen, Elisabeth I. Heath, Lakshminarayan Nandagopal, Hani M. Babiker, Sumanta K. Pal, Michael Lilly, Benjamin L. Maughan, Benjamin Haaland, Mark Yandell, Oliver Sartor, Neeraj Agarwal   +20 more
doaj   +1 more source

Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]

, 1996
The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie, Billard, Lise-Marie, Magdinier, Frédérique, Dante, Robert   +3 more
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Complex-based analysis of dysregulated cellular processes in cancer [PDF]

, 2014
Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum, Liu, Chao, Madhamshettiwar, Piyush B., Ragan, Mark A., Simpson, Peter T., Song, Sarah, Srihari, Sriganesh   +6 more
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Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish Mutation Carriers in High Risk Breast Cancer Families

Cancer Informatics, 2009
Mutations in two major genes, BRCA1 and BRCA2 , account for up to 30% of families with hereditary breast cancer. Unfortunately, in most families there is little to indicate which gene should be targeted first for mutation screening, which is labor ...
Marie-Laure Vuillaume, Nancy Uhrhammer, Véronique Vidal, Valérie Sylvain Vidal, Valérie Chabaud, Beline Jesson, Fabrice Kwiatkowski, Yves-Jean Bignon   +7 more
doaj   +1 more source

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]

, 2019
Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A, Julian, Colleen G, Martinez, Janel, Matarazzo, Christopher, San-Millán, Iñigo   +4 more
core   +1 more source

Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice [PDF]

, 2014
Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality.
Cotignola, Javier Hernan, de Luca, Paola, de Siervi, Adriana, Gardner, Kevin, Mazza, Osvaldo, Meissl, Roberto Jose, Moiola, Cristian Pablo, Pignataro, Omar Pedro, Rodríguez Seguí, Santiago Andrés, Vallecorsa, Pablo Daniel, Vazquez, Elba Susana, Zalazar, Florencia   +11 more
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Construction and characterization of recombinant adenoviruses expressing human BRCA1 or murine Brca1 genes [PDF]

Cancer Gene Therapy, 2001
Recombinant adenoviruses expressing human BRCA1 (AdBRCA1), murine Brca1 (AdBrca1), three clinically relevant human mutant BRCA1 proteins (t340, C61G, and 1853Stop), or a murine Brca1 C-terminal deletion mutant were constructed and evaluated in vitro.
M, Campbell, O N, Aprelikova, R, van der Meer, R L, Woltjer, C J, Yee, E T, Liu, R A, Jensen   +6 more
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