Results 1 to 10 of about 25,882 (241)

A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2

Cell
Knudson's "two-hit" paradigm posits that carcinogenesis requires inactivation of both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic metabolite methylglyoxal (MGO) transiently bypasses Knudson's paradigm by inactivating
David Perera
exaly   +2 more sources

BRCA2 in mammalian meiosis [PDF]

Trends in Cell Biology, 2022
Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs). Recent evidence suggests that association with unique meiosis-specific cofactors allows BRCA2 to facilitate homologous recombination in germ cells.
Zhang, Jingjing, Nandakumar, Jayakrishnan, Shibuya, Hiroki   +2 more
openaire   +2 more sources

Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

New England Journal of Medicine, 2021
BACKGROUND Poly(adenosine diphosphate–ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality.
A. Tutt, J. Garber, B. Kaufman, G. Viale, D. Fumagalli, P. Rastogi, R. Gelber, E. de Azambuja, A. Fielding, J. Balmaña, S. Domchek, K. Gelmon, S. Hollingsworth, L. Korde, B. Linderholm, H. Bandos, E. Senkus, J. Suga, Z. Shao, Andrew W. Pippas, Z. Nowecki, T. Huzarski, P. Ganz, P. C. Lucas, N. Baker, S. Loibl, R. McConnell, M. Piccart, R. Schmutzler, G. Steger, J. Costantino, A. Arahmani, N. Wolmark, Eleanor T. McFadden, V. Karantza, S. Lakhani, G. Yothers, C. Campbell, C. Geyer   +38 more
semanticscholar   +1 more source

BRCA1 ve BRCA2 Mutasyonlarının Tespitine Yönelik Yeni Nesil Dizileme Temelli Kit Geliştirilmesi ve Rutinde Kullanılan Yöntemler ile Valide Edilmesi

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2021
Amaç: Meme kanseri, kadınlarda en yaygın görülen kanser türü olup, Göğüs Kanseri Duyarlılık gen (BRCA1 ve BRCA2) mutasyonlarının meme ve yumurtalık kanserlerinin önemli bir kısmından sorumlu olduğu bilinmektedir.
İlter Güney, Gözde Girgin Özgümüş
doaj   +1 more source

Clinicopathological Characteristics of Patients with BRCA Mutation Breast Cancer in North Sumatera: Case Report [PDF]

Middle East Journal of Cancer, 2023
The most common cancer in women is breast cancer (BC) with an incidence of 24.2%. BC in younger patients will in general be more forceful, prompting more awful results and a requirement for more forceful treatment which may bring about a higher ...
Dedy Hermansyah, Gracia Pricilia, Yolanda Simamora, Denny Siregar   +3 more
doaj   +1 more source

Prevalence of BRCA1 and BRCA2 pathogenic sequence variants in ovarian cancer patients in the Gulf region: the PREDICT study

BMC Cancer, 2021
Patients with pathogenic sequence variants (PSVs) in BRCA1/BRCA2 are at high risk of developing ovarian cancer (OC). However, genetic testing for BRCA1/BRCA2 PSVs is still not a routine practice in the Middle East.
F. Azribi, E. Abdou, Emad A Dawoud, M. Ashour, Amgad H Kamal, Mohamed Al Sayed, I. Burney   +6 more
semanticscholar   +1 more source

BRCA1 and BRCA2 [PDF]

Current Biology, 2000
Bertwistle D, Ashworth A: Functions of the BRCA1 and BRCA2 genes.Curr Opin Genet Dev 1998, 8:14-20.Rahman N, Stratton MR: The genetics of breast cancer susceptibility.Annu Rev Genet 1998, 32:95-121.Hongbing Z, Tombline G, Weber BL: BRCA1, BRCA2, and DNA damage response: collision or collusion?Cell 1998, 92:433-436.
Bertwistle, David, Ashworth, Alan
openaire   +2 more sources

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

Journal of Clinical Oncology, 2023
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2.
S. Yadav, N. Boddicker, Jie Na, E. Polley, Chunling Hu, S. Hart, Rohan D Gnanaolivu, N. Larson, Susan Holtegaard, Huaizhi Huang, C. A. Dunn, L. Teras, Alpa V. Patel, J. Lacey, S. Neuhausen, Elena Martinez, C. Haiman, Fei Chen, Kathryn J. Ruddy, J. Olson, E. John, Allison W. Kurian, D. Sandler, K. O’Brien, Jack A. Taylor, C. Weinberg, H. Anton-Culver, A. Ziogas, G. Zirpoli, D. Goldgar, J. Palmer, S. Domchek, J. Weitzel, K. Nathanson, P. Kraft, F. Couch   +35 more
semanticscholar   +1 more source

A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes

Medicine, 2022
This study aimed to identify, characterize, and map the important attributes of the top 100 most cited papers on BRCA1 and BRCA2 genes. The scientific literature on BRCA1 and BRCA2 was searched in the Web of Science Core Collection database using the ...
S. Alkhayyat, Muhammad Khan, Tauseef Ahmad, Haroon, Huma Tariq, M. Baig   +5 more
semanticscholar   +1 more source

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report

Cancer Biology & Therapy, 2022
Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs,
Xi Cheng, Haiming Yu, Jinying Li, Xiaona Han, Erhong Meng, Houqing Zhou, Dongliang Wang, Beifang Niu, Xiaotao Zhang   +8 more
doaj   +1 more source