Results 1 to 10 of about 46,564 (215)

BRCA1 ve BRCA2 Mutasyonlarının Tespitine Yönelik Yeni Nesil Dizileme Temelli Kit Geliştirilmesi ve Rutinde Kullanılan Yöntemler ile Valide Edilmesi

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2021
Amaç: Meme kanseri, kadınlarda en yaygın görülen kanser türü olup, Göğüs Kanseri Duyarlılık gen (BRCA1 ve BRCA2) mutasyonlarının meme ve yumurtalık kanserlerinin önemli bir kısmından sorumlu olduğu bilinmektedir.
İlter Güney, Gözde Girgin Özgümüş
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Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report

Cancer Biology & Therapy, 2022
Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs,
Xi Cheng, Haiming Yu, Jinying Li, Xiaona Han, Erhong Meng, Houqing Zhou, Dongliang Wang, Beifang Niu, Xiaotao Zhang   +8 more
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A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)

Molecular & Cellular Oncology, 2021
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via
Xavier Renaudin, Ashok R. Venkitaraman
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A Multicenter Study of Genotype Variation/Demographic Patterns in 2475 Individuals Including 1444 Cases With Breast Cancer in Turkey

European Journal of Breast Health, 2023
Objective:Breast cancer (BC) is the most common cancer type in women and may be inherited, mostly in an autosomal dominant pattern. The clinical diagnosis of BC relies on the published diagnostic criteria, and analysis of two genes, BRCA1 and BRCA2 ...
Ibrahim Boga, Sebnem Ozemri Sag, Nilgun Duman, Sevda Yesim Ozdemir, Mahmut Cerkez Ergoren, Kubilay Dalci, Cem Mujde, Cem Kaan Parsak, Cagla Rencuzogullari, Ozge Sonmezler, Orcun Yalav, Adem Alemdar, Lamiya Aliyeva, Ozlem Bozkurt, Sibel Cetintas, Erdem Cubukcu, Adem Deligonul, Berkcan Dogan, Cemre Ornek Erguzeloglu, Turkkan Evrensel, Sehsuvar Gokgoz, Kazim Senol, Sahsine Tolunay, Esra Akyurek, Neslihan Basgoz, Nuriye Gökçe, Bilge Dundar, Figen Ozturk, Duygu Taskin, Mercan Demirtas, Murat Cag, Omer Diker, Polat Olgun, Sevcan Tug Bozdogan, Munis Dundar, Atil Bisgin, Sehime Gulsun Temel   +36 more
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Investigation of the relationship of TNFRSF11A gene polymorphisms with breast cancer development and metastasis risk in patients with BRCA1 or BRCA2 pathogenic variants living in the Trakya region of Turkey

Balkan Journal of Medical Genetics, 2021
Modifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of BRCA1 or BRCA2.
Özdemir K, Gürkan H, Demir S, Atli E, Özen Y, Sezer A, Tunçbilek N, Çicin İ   +7 more
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Spectrum of germline BRCA mutations in hereditary breast and ovarian cancer syndrome in Indian population: A central reference laboratory experience

Cancer Research, Statistics, and Treatment, 2020
Introduction: There is a growing need for BRCA1/BRCA2 mutation frequencies among hereditary breast and ovarian carcinoma (HBOC) cases, specifically determined on the grounds of personal and family history profiles in the Indian population.
Pratiksha Chheda, Shailesh Pande, Tavisha Dama, Sushant Vinarkar, Milind Chanekar, Shweta Limaye, Nilesh Shah, Kirti Chadha   +7 more
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Clinicopathological Characteristics of Patients with BRCA Mutation Breast Cancer in North Sumatera: Case Report [PDF]

Middle East Journal of Cancer, 2023
The most common cancer in women is breast cancer (BC) with an incidence of 24.2%. BC in younger patients will in general be more forceful, prompting more awful results and a requirement for more forceful treatment which may bring about a higher ...
Dedy Hermansyah, Gracia Pricilia, Yolanda Simamora, Denny Siregar   +3 more
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A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma

Pleura and Peritoneum, 2023
The aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.
Krishnamurthy Kritika, Oh Kei Shing, Alghamdi Sarah, Sriganeshan Vathany, Poppiti Robert   +4 more
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Promotion Effects of Smoking in Polyp Development in Monozygotic Twins with Atypical Colorectal Polyposis

Case Reports in Gastroenterology, 2022
Smoking is a known risk factor for the development of colorectal polyps. Even in familial adenomatous polyposis and serrated polyposis syndrome, smoking is a risk factor of the development of polyps.
Naohisa Yoshida, Hideki Ishikawa, Hidetaka Eguchi, Yasushi Okazaki, Ryohei Hirose, Ken Inoue, Osamu Dohi, Yoshito Itoh, Michihiro Mutoh, Shingo Ishiguro, Hideyuki Ishida   +10 more
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Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements

Сибирский онкологический журнал, 2023
The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova, R. I. Khusainova, I. R. Minniakhmetov   +2 more
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