Results 41 to 50 of about 65,232 (224)
Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]
, 2009 BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...Rodriguez, GC, S V Blank, Gomez Garcia, E. B., O Barnett-Griness, Caligo, M A, de la Hoya, M.,, Schaefer, D.,, SWE-BRCA, Fricker, J. P., Imyanitov, E.N., Engel, C., H T Lynch, Spiess, A.C., Olivier-Faivre, L, Douglas, F., D Frost, E N Imyanitov, Rennert, G. (Gad), Meindl, A., Gschwantler-Kaulich, D. (Daphne), K Offit, De La Hoya, M., Couch, F.J. (Fergus), Milne, R.L. (Roger), Peyrat, JP, Schaefer, D., Johannsson, O.T., Ozcelik, H.,, Askmalm, M. S., Viel, A., Hogervorst, F. B.L., Bergman, Annika,, Arnold, N, Mai, P.L. (Phuong), C F Singer, Hopper, JL, Morrison, Patrick, Sinilnikova, O. M., Blank, S.V. (Stephanie), Weerasooriya, N.,, Group, EMBRACE, Douglas, F. (Fiona), M B Terry, A van den Ouweland, Dagan, E., Manoukian, S.,, Niederacher, D, Allavena, A., Froster, U.G. (U.), O M Sinilnikova, Versmold, B., Hansen, Thomas V.O., Revillion, F.,, Nevanlinna, H.,, Milne, R L, Radice, P.,, Boggess, J.F., Neuhausen, S.L. (Susan), Ding, Y C,, Easton, D F, Osorio, A, S Giraud, Dagan, E, Askmalm, M S, Evans, D.G. (Gareth), Benítez, J. (Javier), Muller, D, Rennert, G, Gómez García, EB, Claes, K.,, Moncoutier, V. (Virginie), Allavena, A, E M John, Moncoutier, V.,, L Barjhoux, F Révillion, Boggess, J F, Pita, G., Peyrat, J. -P, Antoniou, A C, Greene, M. H., S L Neuhausen, Wijnen, JT, Schwartz, P.E. (Peter), Hansen, T.v.O, Schaefer, D. (D.), A B Spurdle, Basil, J., Claes, K., Hopper, J. L., Fricker, J-P, Hansen, T.V., Milne, R.L., Eeles, R., Hopper, J.L., Cajal, T.R.Y., Godwin, AK, Buys, S., Varon-Mateeva, R, P Radice, Jernström, H. (H.), N. Imyanitov, E., Giraud, S. (Sophie), Fiebig, B.,, Montagna, M., Casella, C. (Cinzia), J Brunet, Group, GEMO, Barnett-Griness, O., A Meindl, Allavena, A. (Anna), S Peock, Simard, J. (Jacques), Jernström, Helena, van den Ouweland, A.,, Manoukian, S. (Siranoush), A E Toland, C Engel, Cassini, C., Peyrat, J-P,, Wang, X.,, Cruger, D G, Kaufman, B.,, Verhoef, S, Kirchhoff, T., Barnett-Griness, O.,, Blank, S V, Luccarini, C, A Osorio, Oliver, C T, Goldgar, D.,, Meindl, A, R Gershoni-Baruch, Pfeiler, G. (Georg), J Cook, Szabo, C.I., Kircchoff, T. (Tomas), E. Schwartz, P., Hamann, U. (Ute), Giraud, S, U G Froster, Boggess, JF, Arver, B. (Brita Wasteson), T. Johannsson, O.,, Kaufman, B. (Bella), Muller, D.W. (Danièle), Chen, X.C. (X. C.), G Pita, Tizzoni, L., Froster, U.G., Olivier-Faivre, L.,, Kosarin, K.,, Peterlongo, P, Oliver, C.T., Faivre, L. (Laurence), Milne, RL, Kosarin, K., Andrulis, I. L., Ozcelik, H, Manoukian, S., Antoniou, A.C. (Antonis), Peock, S. (Susan), Nathanson, K L,, Thomassen, M. (Mads), Domchek, SM, Pita, G. (Guillermo), Pfeiler, G.,, Tizzoni, L. (Laura), Schwartz, PE, Moncoutier, V., E Friedman, Mai, P., J Simard, Andrulis, I.L. (Irene), Caligo, MA, Heikinen, T. (Tuomas), Hogervorst, F.B., Schmutzler, RK, Gomez Garcia, E.B., F J Couch, Simard, J.,, Luccarini, C.,, Laitman, Y., Gerdes, A-M. (Anne-Marie), E. Toland, A.,, Spiess, A.-C., Ozcelik, H. (Hilmi), Garcia, E.B.G., Oliver, C.T. (Clare), Morrison, P J,, Eeles, R.,, Evans, D G,, S Cohen, Couch, F J, Domchek, S.M., Gomez Garcia, E B, Ditsch, N.,, B Arver, Caldes, T.,, Deissler, H., McGuffog, L. (Lesley), Weerasooriya, N, Hogervorst, F B L, Kirchhoff, T, Hansen, TV, Terry, MB, Frost, D., Spiess, A. C., Hansen, TVO, Hamann, U, Antoniou, AC, N Arnold, Spiess, AC, Luccarini, C. (Craig), Offit, K, Frost, D, Lynch, H T, Barjhoux, L. (Laure), Cook, J., Greene, M H, J-P Peyrat, F Douglas, Andrulis, I L,, EB Gómez García, Schmutzler, R. K., John, EM, KConFab, S Healey, D G Evans, Beesley, J.,, Caldes, T. (Trinidad), Claes, Kathleen, Beesley, J. (Jonathan), Nathanson, K.L. (Katherine), F Lejbkowicz, Offit, K.,, Kaufman, B, Wang, X, Muller, D., Heikkinen, T., Lalloo, F., Jernström, H, Evans, D G, Kontorovich, T. (Tair), G Pichert, Lalloo, F.,, Cook, M., Pichert, G., C. Rodriguez, G., Askmalm, M.S., B Malmer, Singer, C F, A-M Gerdes, Domchek, S M, C Cassini, Ding, Y. C., Yassin, Y. (Yosuf), Godwin, A.K. (Andrew), McGuffog, L., Buys, S, Weerasooriya, N. (Nayana), Spurdle, A B,, Miron, A., M Piedmonte, Miron, A. (Alexander), Gershoni-Baruch, R.,, Fricker, J.P., Laitman, Y.,, Caldes, T., Hamann, U.,, M Montagna, Sinilnikova, OM, Friedman, E.,, Pfeiler, G., Cruger, D.G., Ozcelik, H., G. Froster, U., Ditsch, N. (Nina), Froster, UG, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Terry, M B,, Y C Ding, Toland, A E, Zikan, M., Daly, M.B. (Mary), L McGuffog, Pita, G.,, Versmold, B, Engel, C.,, Morrison, PJ, Oliver, C T,, J F Boggess, B Kaufman, Caldes, T, Hoya, M. (Miguel) de La, D Niederacher, A Allavena, Hogervorst, FB, Easton, D. F., Stoppa-Lyonnet, D, Peterlongo, P., Stoppa-Lyonnet, D. (Dominique), Caligo, M A,, Montagna, M, Viel, A. (Alessandra), Couch, F. J., Cook, M.,, G. Froster, U.,, GEMO, Zikan, M, Y Yassin, Wijnen, J.T., Family Registry, Breast Cancer, Rodriguez, G. C., Neuhausen, S.L., J Benítez, T Ramón y Cajal, Cruger, DG, Barjhoux, L.,, A C Antoniou, Pichert, G, J Beesley, Nathanson, K. L., S M Domchek, Benitez, J.,, Healey, S, Douglas, F.,, Ramon Y Cajal, T., P Peterlongo, EMBRACE, Group, HEBON, Toland, A.E., Group, KConFab, Greene, M.H., Nevanlinna, H., Hoya, M. de la, Boggess, J.F. (John), Ding, Y C, Gschwantler-Kaulich, D.,, Nathanson, K L, G Chenevix-Trench, Hodgson, S.,, Garcíla, E. B. G., Antoniou, A.C., N. Imyanitov, E.,, Blank, SV, Singer, CF, Yassin, Y.,, Friedman, E, Gerdes, A. M., Andrulis, IL, Mai, P.,, Fricker, J.P. (Jean Pierre), Breast Cancer Family Registry, Stenmark Askmalm, Marie, Lynch, H.T., Deissler, H.,, Wakeley, K., Goldgar, D., Claes, K, H Ozcelik, M Barile, Szabo, C. I., Barjhoux, L., Nevanlinna, H, Caligo, M.A. (Maria), Schmutzler, R K, Goldgar, D, Laitman, Y. (Yael), Nevanlinna, H. (Heli), Van Den Ouweland, A., Morrison, P. J., Pichert, G.,, Chen, X., Yannoukakos, D.,, Hansen, Thomas V O, Simard, J., Easton, D.F., Arver, B.,, Godwin, A K,, V. Blank, S., Johannson, O.T. (Oskar), Radice, P, Frost, D.,, Chenevix-Trench, G., Basil, J.,, Sinilnikova, O.M., Brunet, J.,, Ding, Y.C., U Hamann, K. Schmutzler, R.,, Cassini, C, Imyanitov, EN, Hansen, T.V.O. (Thomas), Hansen, T. V. O., Gerdes, A-M,, K. Schmutzler, R., H Deißler, Garcia, E.B. Gomez, Healey, S. (Sue), J-P Fricker, Sinilnikova, O M, C I Szabo, Foretova, L., Garcia, EBG, Gershoni-Baruch, R, Versmold, B.,, Fiebig, B. (Britta), M S Askmalm, Niederacher, D., F Lalloo, Fricker, JP, Zikan, M.,, Douglas, F, Barnett-Griness, O, Miron, A.,, Gomez Garcia, E B,, S Manoukian, Greene, MH, R L Milne, N Ditsch, Piedmonte, M, Kontorovich, T., J Basil, Rodriguez, G C, Chenevix-Trench, G.,, Greene, M.H. (Mark), Osorio, A.,, Friedman, E., Milne, R L,, Hopper, J L, Froster, U. G., R Eeles, Basil, J, Cassini, C. (C.), Blank, S.V., Lynch, H. (Henry), Morrison, P J, A-C Spiess, Spurdle, Amanda B., Spurdle, AB, Lynch, HT, Domchek, S.M. (Susan), v. O. Hansen, Thomas,, Godwin, A K, Ramón Y Cajal, T, Moncoutier, V, T Caldes, Sinilnikova, O M,, Wakeley, K.,, Evans, DG, John, E.M. (Esther), Hogervorst, F.B.L. (Frans), Giraud, S., v. O. Hansen, Thomas, D Yannoukakos, Peyrat, J. P., A Miron, Johannsson, O T, Terry, M. B., Miron, A, L Foretova, Chen, X.,, Piedmonte, M.,, M A Caligo, Fiebig, B, Schaefer, D, S Hodgson, Szabo, C I,, Spiess, A. -C, Kirchhoff, T.,, Andrulis, I L, Daly, M.,, Hogervorst, FBL, Cajal, T. Ramon y,, Oliver, CT, Casella, C., Ditsch, N, R Varon-Mateeva, John, E M, Spiess, A-C,, Group, SWE-BRCA, Gerdes, A.-M., Y Laitman, Pfeiler, G, Fricker, J. -P, Pita, G, Mai, P, Giraud, S.,, Kosarin, K. (Kristi), C Casella, Lejbkowicz, F. (Flavio), Yannoukakos, D. (Drakoulis), X Wang, Claes, K. (Kathleen), Buys, S. M., Révillion, F, Imyanitov, E.N. (Evgeny), Cruger, D. G., Schmutzler, R.K. (Rita), Ramon, Y.Cajal, K Wakeley, P Mai, Nathanson, K.L., Ditsch, N., Lindor, N.,, Arnold, N.,, Group, OCGN, G Rennert, Morrison, P.J., Chenevix-Trench, G, G Pfeiler, Arver, B., B Fiebig, Couch, FJ, Offit, K., Evans, D.G., Schwartz, P.E., Hogervorst, F. B. L., Ouweland, A.M.W. (Ans) van den, Malmer, Beatrice,, Eeles, R, Szabo, C I, Tizzoni, L, Healey, S., Hodgson, S., E. Toland, A., S Verhoef, Benítez, J, Singer, C F,, Montagna, M.,, Foretova, L.,, T Heikkinen, Engel, C, John, E. M., Dagan, E. (Efrat), V Moncoutier, Yannoukakos, D., M H Greene, Toland, A.E. (Amanda), Froster, U G, Domchek, S M,, Neuhausen, S. L., Cajal, T. Ramon y, Rennert, G.,, Kontorovich, T.,, Beesley, J, Meindl, A.,, McGuffog, L.,, Jernstrom, H., Heikkinen, T.,, OCGN, Malmer, B, J T Wijnen, K Kosarin, Johannsson, OT, Schwartz, P E, F. Boggess, J., Garcíla, EBG, Laitman, Y, Yannoukakos, D, Allavena, A.,, Couch, F.J., Hodgson, S.V. (Shirley), C T Oliver, Kontorovich, T, Szabo, CI, Niederacher, D.,, Daly, M., Chen, X, D Muller, Foretova, L, Yassin, Y., Hamann, U., Spurdle, A B, Toland, AE, T Kirchhoff, Wang, X., Peyrat, J.P., John, E M,, Barile, M, M Thomassen, Cruger, D. (Dorthe), Hansen, Thomas v. O., E Dagan, E. Schwartz, P.,, Caligo, M. A., Wakeley, K. (Katie), Buys, S.S. (Saundra), S Buys, Manoukian, S, Brunet, J., Spurdle, A.B., Benitez, J., A K Godwin, M Cook, Neuhausen, SL, Viel, A, Simard, J, Milne, R. L., Casella, C.,, Cohen, S.,, Lindor, N., Cook, J. (Jackie), Healey, S.,, Muller, D.,, M de la Hoya, Stoppa-Lyonnet, D.,, Ding, YC, Couch, F J,, Thomas v O Hansen, Lynch, H T,, CMBA, Thomassen, M.,, Verhoef, S.,, H Jernström, D Gschwantler-Kaulich, Peterlongo, P.,, Imyanitov, E. N., Brunet, J, Toland, A. E., Offit, K. (Kenneth), N Lindor, Rodriguez, G.C. (Gustavo), Arnold, N., Gerdes, A-M, D Schaefer, Garcíla, E.B.G. (E.B. Gómez), Thomassen, M, O T Johannsson, Rennert, G., Yassin, Y, Gershoni-Baruch, R., Cook, J.,, Gschwantler-Kaulich, D., Neuhausen, S L,, K Claes, C. Rodriguez, G.,, Tizzoni, L.,, Barjhoux, L, Revillion, F., Dagan, E.,, John, E.M., Malmer, B. (Beatrice), Brunet, J. (Joan), P E Schwartz, Easton, DF, Fiebig, B., Boggess, J. F., Terry, M.B., Piedmonte, M., Jernstrom, H.,, Hogervorst, F.B.L., Meindl, A. (Alfons), García, Eb Gómez, Blank, S. V., P J Morrison, C Luccarini, Hopper, J.L. (John), Singer, C.F., Casella, C, Singer, C.F. (Christian), Cassini, C.,, Askmalm, M.S. (Marie), Wijnen, J. T., Stenmark Askmalm, Marie,, Hogervorst, F B L,, D Stoppa-Lyonnet, Viel, A.,, Wang, X. (Xing), Spiess, E. (Eberhard), Nathanson, KL, Niederacher, D. (Dieter), Godwin, A.K., Heikkinen, T, Deiler, H. (H.), Verhoef, S., Varon-Mateeva, R., X Chen, H Nevanlinna, Andrulis, I.L., Caligo, M.A., Spiess, A-C, Johannsson, O. T., Lejbkowicz, F., Barile, M., Cohen, S, Sinilnikova, O. (Olga), Fricker, J-P,, Schmutzler, R.K., Olivier-Faivre, L., Goldgar, D. (David), Piedmonte, M. (Marion), Lalloo, F, Basil, J. (Jack), Terry, M B, Arnold, N. (Norbert), F B L Hogervorst, F. Boggess, J.,, Daly, M, Antoniou, A. C., Malmer, B., C. Antoniou, A., Cook, M, Beesley, J., Peock, S.,, Osorio, A. (Ana), B Versmold, Kaufman, B., Wakeley, K, Lynch, H. T., Cook, J, Szabo, C. (Csilla), Varon-Mateeva, R.,, Malmer, B.,, Pichert, G. (Gabriella), Cruger, D G,, Chenevix-Trench, G. (Georgia), R K Schmutzler, Peyrat, J-P, Easton, D F,, Kosarin, K, Oliver, C. T., Friedman, E. (Eitan), J L Hopper, Eeles, R. (Rosalind), Askmalm, MS, Lindor, N.M. (Noralane), Imyanitov, E N, de la Hoya, M, Hopper, J L,, Thomassen, M., Versmold, B. (Beatrix), Ouweland, A.M.W. van den, D G Cruger, Lalloo, F. (Fiona), Peyrat, J.-P., Gerdes, A. -M, Cajal, TRY, Zikan, M. (Michal), Montagna, M. (Marco), Easton, D.F. (Douglas), Lejbkowicz, F.,, Peock, S., Garcíla, E. B.Gómez, Weerasooriya, N., Cohen, S. (Shimrit), Morrison, P.J. (Patrick), Lejbkowicz, F, I L Andrulis, van den Ouweland, A, Ouweland, A. van den, Spurdle, A. B., Peock, S, Wijnen, J T, Hodgson, S, Révillion, F. (Françoise), L Olivier-Faivre, D F Easton, Gerdes, A.M., Luccarini, C., Radice, P. (Paolo), Wijnen, J.T. (Juul), Arver, B, Deissler, H, Domchek, S. M., HEBON, M Daly, M Zikan, V. Blank, S.,, Evans, D. G., Foretova, L. (Lenka), Osorio, A., Terry, M.-B. (Mary-Beth), Rodriguez, G.C., Radice, P., Buys, S.,, Gerdes, AM, Cook, M. (Margaret), Deiler, H., Wijnen, J T,, Cohen, S., Barile, M. (Monica), Frost, D. (Debra), Barnett-Griness, O. (Ofra), Godwin, A. K., T Kontorovich, D Goldgar, N Weerasooriya, Greene, M H,, McGuffog, L, K L Nathanson, G C Rodriguez, T. Johannsson, O., Nordling, Margareta,, Varon-Mateeva, R. (Raymonda), Lindor, N, Neuhausen, S L, Ding, Y.C. (Yuan), Singer, C. F., Spurdle, A.B. (Amanda), Schwartz, P. E., A Viel, C. Antoniou, A.,, Engel, C. (Christoph), Fricker, J.-P., Gschwantler-Kaulich, D, Barile, M.,, L Tizzoni, Osorio, A;Milne, RL;Pita, G;Peterlongo, P;Heikkinen, T;Simard, J;Chenevix-Trench, G;Spurdle, AB;Beesley, J;Chen, X;Healey, S;Neuhausen, SL;Ding, YC;Couch, FJ;Wang, X;Lindor, N;Manoukian, S;Barile, M;Viel, A;Tizzoni, L;Szabo, CI;Foretova, L;Zikan, M;Claes, K;Greene, MH;Mai, P;Rennert, G;Lejbkowicz, F;Barnett-Griness, O;Andrulis, IL;Ozcelik, H;Weerasooriya, N;Gerdes, AM;Thomassen, M;Cruger, DG;Caligo, MA;Friedman, E;Kaufman, B;Laitman, Y;Cohen, S;Kontorovich, T;Gershoni-Baruch, R;Dagan, E;Jernstrom, H;Askmalm, MS;Arver, B;Malmer, B;Domchek, SM;Nathanson, KL;Brunet, J;Ramón y Cajal, T;Yannoukakos, D;Hamann, U;Hogervorst, FB;Verhoef, S;Gómez García, EB;Wijnen, JT;van den Ouweland, A;Easton, DF;Peock, S;Cook, M;Oliver, CT;Frost, D;Luccarini, C;Evans, DG;Lalloo, F;Eeles, R;Pichert, G;Cook, J;Hodgson, S;Morrison, PJ;Douglas, F;Godwin, AK;Sinilnikova, OM;Barjhoux, L;Stoppa-Lyonnet, D;Moncoutier, V;Giraud, S;Cassini, C;Olivier-Faivre, L;Revillion, F;Peyrat, JP;Müller, D;Fricker, JP;Lynch, HT;John, EM;Buys, S;Daly, M;H, OCGN Investigators, Jernström, Helena,, Lucassen, Anneke, Lund University., et al., +815 morecore +1 more sourceRPA, RFWD3 and BRCA2 at stalled forks: a balancing act
Molecular & Cellular Oncology, 2020 We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee Haohui Duan, Shailja Pathaniadoaj +1 more sourceHypersensitivity of BRCA1 heterozygote lymphoblastoid cells to gamma radiation and PARP inhibitors [PDF]
, 2013 This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Bourton EC, et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use ...Bourton, EC, Plowman, PN, Parris, C, Parris, CN, Foster, HA, Harvey, AJ +5 morecore +1 more sourceChronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...Anu Singh, Aroonima Misra, Sufian Zaheerwiley +1 more sourceIntegrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer
Advanced Science, EarlyView.Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang +11 morewiley +1 more sourceLimited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing [PDF]
Journal of Immunotherapy and Precision OncologyIntroduction
Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator.Carol J. Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E. Ileana Dumbrava, Ying Yuan, Keyur P. Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A. Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A. Yap, Banu Arun, Karen H. Lu, Funda Meric-Bernstam +18 moredoaj +1 more sourceDDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response
Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li +8 morewiley +1 more source
