Results 31 to 40 of about 60,203 (254)

Bayesian assessment of the prevalence of BRCA-associated breast cancer in Moscow

open access: yesAlʹmanah Kliničeskoj Mediciny, 2020
Rationale: For many years, breast cancer has been leading in the cancer structure in women, accounting for 21% from the total number of newly diagnosed cases of malignancies in Russia. The literature on the prevalence of the BRCA-associated breast cancer
A. V. Viskovatykh
doaj   +1 more source

Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements

open access: yesСибирский онкологический журнал, 2023
The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova   +2 more
doaj   +1 more source

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]

open access: yes, 2009
BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...
Rodriguez, GC   +809 more
core   +1 more source

A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

open access: yesMolecular & Cellular Oncology, 2021
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González   +3 more
doaj   +1 more source

Founder mutations in Nepalese population [PDF]

open access: yesJournal of Pathology and Translational Medicine, 2022
Background Founder mutation is a heritable genetic alteration observed with high frequency in a geographically and culturally isolated population where one or more ancestors becomes the forebearer of the altered gene.
Anurag Mehta   +5 more
doaj   +1 more source

Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a defined personal and family history in an Ashkenazi Jewish woman (LAMBDA) [PDF]

open access: yes, 2003
INTRODUCTION: Ancestral mutations in BRCA1 and BRCA2 are common in people of Ashkenazi Jewish descent and are associated with a substantially increased risk of breast and ovarian cancer.
Ellen Solomon   +30 more
core   +1 more source

Detection of BRCA2 Genes Polymorphism among Prostate Cancer Patients in Sudan 2020: A Case-Control Study [PDF]

open access: yesJournal of Liaquat National Hospital
Background: Prostate cancer (PCa) has been associated with BRCA2 mutations; however, reported risk estimates differ greatly, mainly because of variations in retrospective study designs.
Randa Elginad   +7 more
doaj   +1 more source

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]

open access: yes, 2012
Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...
Dutra-Clarke, Ana   +999 more
core   +1 more source

BRCA2 Haploinsufficiency in Telomere Maintenance [PDF]

open access: yes, 2022
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadOur previous studies showed an association between monoallelic BRCA2 germline
Gunnarsdottir, Soffía R.   +6 more
core   +1 more source

BRCA1/2 Expression Patterns in Different Grades of Oral Squamous Cell Carcinoma [PDF]

open access: yesMiddle East Journal of Cancer, 2020
Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and has a poor prognosis. The breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes are the key tumor suppressor genes responding in the cases of DNA damage ...
Soussan Irani, Mitra Rafizadeh
doaj   +1 more source

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