Results 11 to 20 of about 60,203 (254)

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2 -Mutated Ovarian Carcinoma [PDF]

Cancer Research, 2009
Abstract Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma ...
Sakai, Wataru, Swisher, Elizabeth M, Jacquemont, Céline, Chandramohan, Kurapaty Venkatapoorna, Couch, Fergus J, Langdon, Simon P, Wurz, Kaitlyn, Higgins, Jake, Villegas, Emily, Taniguchi, Toshiyasu   +9 more
openaire   +5 more sources

BRCA2 Haploinsufficiency in Telomere Maintenance [PDF]

Genes, 2021
Our previous studies showed an association between monoallelic BRCA2 germline mutations and dysfunctional telomeres in epithelial mammary cell lines and increased risk of breast cancer diagnosis for women with BRCA2 999del5 germline mutation and short telomeres in blood cells.
Soffía R. Gunnarsdottir, Hördur Bjarnason, Birna Thorvaldsdottir, Felice Paland, Margrét Steinarsdottir, Jórunn E. Eyfjörd, Sigrídur K. Bödvarsdottir   +6 more
openaire   +3 more sources

BRCA2 in mammalian meiosis [PDF]

Trends in Cell Biology, 2022
Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs). Recent evidence suggests that association with unique meiosis-specific cofactors allows BRCA2 to facilitate homologous recombination in germ cells.
Zhang, Jingjing, Nandakumar, Jayakrishnan, Shibuya, Hiroki   +2 more
openaire   +2 more sources

Suppression of polyploidy by the BRCA2 protein

Cancer Letters, 2007
Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization.
Sagulenko, Evgeny, Savelyeva, Larissa, Ehemann, Volker, Sagulenko, Vitaliya, Hofmann, Wera, Arnold, Katrin, Claas, Andreas, Scherneck, Siegfried, Schwab, Manfred   +8 more
openaire   +6 more sources

Tetraploidy in BRCA2 breast tumours

European Journal of Cancer, 2012
Tetraploidy and aneuploidy can be caused by cell division errors and are frequently observed in many human carcinomas. We have recently reported delayed cytokinesis in primary human fibroblasts from BRCA2 mutation carriers, implying a function for the BRCA2 tumour suppressor in completion of cell division.
Asta Bjork, Jonsdottir, Olafur Andri, Stefansson, Johannes, Bjornsson, Jon G, Jonasson, Helga M, Ogmundsdottir, Jorunn E, Eyfjord   +5 more
openaire   +3 more sources

BRCA1 and BRCA2 [PDF]

Current Biology, 2000
Bertwistle D, Ashworth A: Functions of the BRCA1 and BRCA2 genes.Curr Opin Genet Dev 1998, 8:14-20.Rahman N, Stratton MR: The genetics of breast cancer susceptibility.Annu Rev Genet 1998, 32:95-121.Hongbing Z, Tombline G, Weber BL: BRCA1, BRCA2, and DNA damage response: collision or collusion?Cell 1998, 92:433-436.
Bertwistle, David, Ashworth, Alan
openaire   +2 more sources

BRCA2 and homologous recombination [PDF]

Breast Cancer Research, 2001
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
B J, Orelli, D K, Bishop
openaire   +2 more sources

The BRCA2 is a histone acetyltransferase [PDF]

Oncogene, 1998
Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique, J P, Zou, V N, Rao, E S, Reddy   +3 more
openaire   +2 more sources

Clinical consequences of BRCA2 hypomorphism [PDF]

npj Breast Cancer, 2021
AbstractThe tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary breast and ovarian cancer predisposition.
Laia Castells-Roca, Sara Gutiérrez-Enríquez, Sandra Bonache, Massimo Bogliolo, Estela Carrasco, Miriam Aza-Carmona, Gemma Montalban, Núria Muñoz-Subirana, Roser Pujol, Cristina Cruz, Alba Llop-Guevara, María J. Ramírez, Cristina Saura, Adriana Lasa, Violeta Serra, Orland Diez, Judith Balmaña, Jordi Surrallés   +17 more
openaire   +6 more sources

A Case of Triple-Negative Breast Cancer with Germline Pathogenic Variants in Both BRCA1 and BRCA2

Case Reports in Oncology, 2021
We report a rare case of hereditary breast and ovarian cancer syndrome (HBOC) with pathogenic variants in both BRCA1 and BRCA2. The patient was a 78-year-old woman who visited the hospital after noticing a lump in her left breast 6 months before, which ...
Miyuki Kitahara, Yasuo Hozumi, Mitsuki Machinaga, Yuka Hayashi   +3 more
doaj   +1 more source