Results 61 to 70 of about 60,203 (254)
Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma
Advanced Science, EarlyView.MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu +21 morewiley +1 more sourceCommon breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
, 2011 The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...Donaldson, A., Danièle Muller, Mark H Greene, L Mai, Phuong,, SWE-BRCA, Madeleine MA Tilanus Linthorst, Engel, C., Pankratz, Vernon, Murray, A, Muy-Kheng Tea, Barrowdale, D., Paul DP Pharoah, Wachenfeldt, v.A., Lynch, Henry, Maria A Caligo, Network, OCG, Wachenfeldt, A. (Anna) von, Anne Marie Gerdes, Boutry-Kryza, Nadia, Barkardottir, Rosa B, F Easton, Douglas,, Varon-Mateeva, Raymonda, Investigators, K, Tilanus-Linthorst, Madeleine M. A., Ozcelik, Hilmi, Pascal Pujol, Breast Canc Family Registry, Kast, K, Kets, C.M. (Marleen), Raymonda Varon Mateeva, Wachenfeldt, V., Martine Dumont, Ejlertsen, B. (Bent), Meindl, A., K Godwin, Andrew, Gschwantler-Kaulich, D. (Daphne), Viel, Alessandra, Meijers-Heijboer, Hanne E.J., Heli Nevanlinna, Patricia A. Ganz, de la Hoya, Miguel, Andrew K. Godwin, Couch, F.J. (Fergus), Skytte, Anne-Bine, Paolo Peterlongo, Janavicius, Ramunas,, Bonanni, Bernardo, Ana Osorio, John L Hopper, Viel, A., Y Karlan, Beth,, Arnold, N, Soller, M., Mai, P.L. (Phuong), Caldes, Trinidad,, Hopper, JL, Olopade, Olufunmilayo, Ruehl, Ina, Gross, J. (Jenny), Eason, J., Chung, Wendy K., Kirsten B. Moysich, A. C. Breast Cancer Family Registry Antoniou, Wachenfeldt, VA, Arver, Brita, A Ganz, Patricia, Pujol, P, Brita Arver, Niederacher, D, Hansen, Thomas V.O., Miguel de la Hoya, Radice, Paolo,, Mark Sherman, Rookus, Matti, Sherman, Mark, Berthet, Pascaline, Benitez, Javier,, Verheus, Martijn, François Cornelis, Godino, J, Neuhausen, S.L. (Susan), Douglas F. Easton, Mulligan, A.M., S Pankratz, Vernon, Osorio, A, Hardouin, A, Os, Theo V., Antonis C. Antoniou, Rebbeck, Timothy R, Esther M John, Mazoyer, S, Aittomäki, K., Evans, D.G. (Gareth), Blanco, I, Rosa B. Barkardottir, Benítez, J. (Javier), Lee, A, Papi, Laura, Muller, D, Gómez García, EB, Kirsten B Moysich, Deissler, Helmut,, van Os, Theo, Gordon Glendon, Lebrun, Marine, Michel Longy, Spurdle, Amanda B, Antoniou, Antonis, Frances P. O'Malley, Pujol, Pascal,, Greene, Mark H., Ganz, Patricia A, Cattaneo, E., Iván Muñoz-Repeto, Berthet, P., Daphne Gschwantler-Kaulich, Gross, Jenny, Henry T. Lynch, J Louise Jones, Susan L Neuhausen, Buys, Saundra M, Mortemousque, Isabelle, Coupier, Isabelle,, Pertesi, M, Fricker, J-P, Ignacio Blanco, Hansen, T.V., Donaldson, A, Peissel, Bernard,, Fredericksen, Z, Henriksson, K, Eeles, R., van Der Luijt, Rob, Niederacher, Dieter,, Hopper, J.L., Godwin, AK, Fassy-Colcombet, M. (Marion), Tilanus-Linthorst, Madeleine M.A., Schäfer, D., Eason, J. (Jacqueline), Peock, Susan,, Cornelis, F, Peterlongo, Paolo, Evans, D. Gareth; id_orcid, Glendon, Gordon,, Pharoah, P.D.P., Dieter Schäfer, Varon-Mateeva, R, Olopade, O.I., Kruse, Torben A, Ganz, P.A. (Patricia), Ros Eeles, Chung, W., Terry, Mary, Beattie, M., Leone, Melanie,, Montagna, M., Javier Godino, Robson, Mark,, Durán, M., Kruse, Torben A., Gregory, H, Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Pankratz, Vernon S, Davidson, R., Fricker, Jean-Pierre, Soucy, Penny, Susan J. Ramus, Raymonda Varon-Mateeva, Berthet, P. (Pascaline), Jensen, Uffe, Birk, Tilanus-Linthorst, M.M.A. (Madeleine), Simard, J. (Jacques), Miron, Alexander F., Manoukian, S. (Siranoush), Julian Barwell, Kruse, T.A., Godino, J. (Javier), van Os, Theo,, Os, Theo van, Robson, Mark, Sue Healey, Frances P O'Malley, Gerdes, Anne-Marie, GEMO Study Collaborators, Madeleine MA Tilanus-Linthorst, Bonanni, Bernardo,, Singer, Christian, Caux-Moncoutier, V. (Virginie), Engel, Christoph, Tognazzo, Silvia,, Kauff, N. (Noah), Pertesi, Maroulio,, Torben A. Kruse, Adlard, Julian,, Aittomäki, K. (Kristiina), Sakr, R. (Rita), Ramunas Janavicius, Buys, SM, Ottini, Laura,, Schäfer, Dieter, Marie Stenmark-Askmalm, Soller, Maria,, Janavicius, R, Gevensleben, H, Heidrun Gevensleben, Rookus, M, Hansen, Thomas V., Godwin, Andrew K, Christian Sutter, Meindl, A, DAndrea, Emma,, Karlan, B.Y., Muy Kheng Tea, Sevenet, N., Mai, Phuong L, Toland, Amanda E, Dieter Niederacher, Caux-Moncoutier, V, Benítez, J., Wijnen, J., Muller, Danièle, Hamann, U. (Ute), Ottini, Laura, Moysich, Kirsten B., Gross, J, Madeleine M. A. Tilanus Linthorst, Iván Muñoz Repeto, E Side, Lucy, Susan J Ramus, Henry T Lynch, Arver, B. (Brita Wasteson), Muller, D.W. (Danièle), Isaacs, Claudine, Barrowdale, Daniel,, Esther M. John, Peterlongo, P, Southey, Melissa C., Fredericksen, Z., Hansen, Thomas vO., Olopade, Olufunmilayo I, Bhatia, Jasmine, Wijnen, J, Heinritz, W., Mai, PL, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Antoniou, A.C. (Antonis), Gerdes, Anne-Marie,, Peock, S. (Susan), Thomassen, M. (Mads), Gómez García, Encarna B., Domchek, SM, Daniel Barrowdale, Henriksson, Karin, Kientz, Caroline,, Caux-Moncoutier, Virginie, Gaudet, M., Kets, C Marleen,, Sevenet, Nicolas,, Kauff, N, Adlard, J.W. (Julian), Adlard, J, Lee, A. (Andrew), Mortemousque, Isabelle,, Easton, Douglas F., Melissa C Southey, Ruehl, I. (Ina), Léoné, Mélanie, Skytte, A.-B. (Anne-Bine), Emma McCann, Lebrun, M., Bernard Peissel, Andrulis, I.L. (Irene), Lazaro, C, Caligo, MA, Hanne EJ Meijers-Heijboer, Os, Theo v, Wang, X.S., Caux-Moncoutier, V., Houghton, C., Heikinen, T. (Tuomas), Jacqueline Eason, Deissler, H. (Helmut), Schmutzler, RK, Anne Bine Skytte, Gadzicki, D. (Dorothea), Saundra M. Buys, Donaldson, Alan,, Gerdes, A-M. (Anne-Marie), O'Malley, Frances, F Miron, Alexander,, Maria A. Caligo, Weitzel, JN, Seynaeve, C.M. (Caroline), Sutter, C., Pharoah, Paul D. P., Ozcelik, H. (Hilmi), Anne-Marie Gerdes, Helmut Deissler, Gaudet, Mia,, Finn C Nielsen, F Miron, Alexander, Garcia, E.B.G., Rookus, M., Eccles, Diana,, Coupier, I., Fassy-Colcombet, Marion, Caligo, Maria A, Toland, Amanda E., Penny Soucy, L Nathanson, Katherine, McCann, E., Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, Meindl, Alfons,, C Southey, Melissa,, Domchek, S.M., Deissler, H., Mazoyer, S., Eeles, Ros, McGuffog, L. (Lesley), Tea, Muy-Kheng, Preisler-Adams, Sabine,, Gadzicki, D, Fergus J Couch, Hansen, TV, Frost, D., Terry, MB, Marcel R Nelen, Vernon S Pankratz, Marion Fassy Colcombet, Os, T. van, Neuhausen, Susan, Hopper, John L., Hansen, TVO, B Barkardottir, Rosa,, Hamann, U, Conxi Lazaro, Schoenbuchner, Ines, Imyanitov, E., Antoniou, AC, Rosemarie Davidson, Isaacs, C., Wachenfeldt, von A, Soller, M, Pujol, Pascal, Davidson, R, Donaldson, Alan, Eason, Jacqueline,, Adlard, Julian, Offit, K, Sherman, M.E. (Mark), Donaldson, A. (Alan), Frost, D, Daly, Mary B, Schaefer, Dieter, Cook, J., Wang, XS, Wang, Xianshu, Ottini, L, Caligo, Maria, Peock, Susan, Hansen, Thomas v, Karlan, BY, Moysich, Kirsten B, Rhiem, K, Mazoyer, S. (Sylvie), E. M. John, Yan, M. (Max), Benitez, Javier, Boutry-Kryza, N, Muñoz-Repeto, I., Papi, L., Ontario Canc Genetics Network, Ding, Yuan,, Lee, A., Nielsen, FC, Luijt, R.B. (Rob) van der, Mary B. Daly, John, EM, Preisler-Adams, S. (Sabine), Barkardottir, R.B. (Rosa), Wachenfeldt, von Anna, Mulligan, AM, Sakr, R., Chung, W. (Wendy), Caldes, T. (Trinidad), Kientz, C, Nathanson, K.L. (Katherine), Izatt, Louise, Savarese, A., Pankratz, V.S. (Shane), Os, Theo, Rita K. Schmutzler, Wang, X, Muller, D., Sutter, C, Gadzicki, Dorothea,, Kientz, Caroline, Manoukian, Siranoush,, Ganz, P.A., Lalloo, F., Heikkinen, T., Alan Donaldson, Wang, Xianshu,, C Marleen Kets, Evans, D G, Mortemousque, I. (Isabelle), Houghton, Catherine,, Ontario Cancer Genetics Network, Adlard, J., Loris Bernard, Bhatia, Jasmine,, Os, Theo, Van, Hamann, Ute, Yan, Max, Cornelis, F. (Franco̧is), Fassy-Colcombet, M., E Tomlinson, Gail, Singer, Christian F, Kruse, T.A. (Torben), Norbert Arnold, Kets, C Marleen, Easton, Douglas, Jean Pierre Fricker, Godwin, A.K. (Andrew), McGuffog, L., Blanco, I., Peissel, Bernard, Stenmark-Askmalm, M., Schaefer, Dieter,, Sevenet, N. (Nicolas), Sevenet, N, Miron, A. (Alexander), P OMalley, Frances,, Radice, Paolo, Frost, Debra, Ganz, PA, van der Luijt, RB, Jeffrey N Weitzel, Fricker, J.P., Arnold, Norbert, L Andrulis, Irene,, Rebbeck, T, Kast, Karin, Pharoah, Paul DP, Ramus, S.J., Barkardottir, Rosa, Caldes, T., Daly, Mary B., Gregory, Helen,, Sakr, R, Murray, A., Miron, AF, Ruehl, Ina,, Sinilnikova, OM, Maroulio Pertesi, Jones, J Louise, Meijers-Heijboer, Hanne E, Fricker, Jean-Pierre,, Chun Ding, Yuan, Side, L.E., Boutry-Kryza, Nadia,, Ramus, Susan J, C. Marleen Kets, Noah Kauff, Ozcelik, H., Caroline Seynaeve, Trinidad Caldes, Daphne Gschwantler Kaulich, Soucy, Penny,, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Munoz-Repeto, Ivan,, Rookus, M.A. (Matti), A Ganz, Patricia,, Soller, Maria, Side, Lucy E, Dorkins, H, Daly, M.B. (Mary), Henriksson, Karin,, D P Pharoah, Paul,, Glendon, Gordon, A Kruse, Torben,, van Os, T., Wijnen, Juul, McCann, Emma, H Greene, Mark, Karlsson, Per,, Karin Kast, Fredericksen, Z. (Zachary), Huw Dorkins, Caldes, T, Hoya, M. (Miguel) de La, Paul D. P. Pharoah, Alexander F. Miron, Cattaneo, Elisa, Stenmark-Askmalm, M, D P Pharoah, Paul, Gail E. Tomlinson, Susan M Domchek, Stoppa-Lyonnet, D, Tilanus-Linthorst, Madeleine M A, Peterlongo, P., Lázaro, C. (Conxi), Garcia, Encarna B. Gomez, Barwell, Julian, John, Esther, Greene, Mark H, Gevensleben, H. (Heidrun), Stoppa-Lyonnet, D. (Dominique), Bent Ejlertsen, Montagna, M, Beattie, Mary, Ejlertsen, B, Caux-Moncoutier, Virginie,, Viel, A. (Alessandra), Anneliese Fink-Retter, Peterlongo, Paolo,, Nelen, Marcel R, Encarna B Gómez García, Mulligan, Anna, Marie, Jackie Cook, Dumont, M., Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Family Registry, Breast Cancer, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., L Neuhausen, Susan, Lazaro, Conxi, Ejlertsen, Bent,, Evgeny Imyanitov, Anna Marie Mulligan, Terry, Mary B., Soucy, P., Eason, J, Martijn Verheus, Tomlinson, Gail E, Arver, Brita,, Gevensleben, Heidrun, Heikkinen, Tuomas, Toland, Amanda, Isabelle Mortemousque, Tilanus-Linthorst, MMA, Dorkins, Huw, Healey, S, McCann, Emma,, Aittomäki, Kristiina, Heinritz, W. (Wolfram), Couch, Fergus, I Olopade, Olufunmilayo, Tognazzo, S., Tomlinson, G.E., EMBRACE, Dorothea Gadzicki, Hardouin, Agnès, Preisler-Adams, S., Toland, A.E., Greene, M.H., Karlan, Beth, Nevanlinna, H., Coupier, Isabelle, Hoya, M. de la, Nathanson, Katherine L, von Wachenfeldt, Anna, Pasini, B, Sutter, Christian,, A Caligo, Maria,, McGuffog, Lesley, Lazaro, C (Conxi), Fink-Retter, A. (Anneliese), Hilmi Ozcelik, Collaborators, GEMOS, Pharoah, Paul D P, Lee, Andrew, Sakr, Rita, Jensen, UB, Simard, Jacques,, Chung, Wendy,, Ruehl, I., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, B Barkardottir, Rosa, Hopper, John, Jones, J L, Schmutzler, Rita, Antoniou, A.C., Heikkinen, Tuomas,, Claudine Isaacs, Boutry-Kryza, N., M Buys, Saundra, Singer, CF, Papi, Laura,, Ding, Yuan C., Hardouin, Agnes,, Blanco, Ignacio, Lynch, Henry T., Mulligan, Anna,, Chun Ding, Yuan,, Ottini, L. (Laura), Andrulis, IL, Fricker, J.P. (Jean Pierre), Susan M. Domchek, Breast Cancer Family Registry, Pankratz, VS, Sherman, M, Stenmark Askmalm, Marie, Lynch, H.T., Side, L. (Lucy), Lazaro, Conxi,, Meijers-Heijboer, E.J. (Hanne), Goldgar, D., Nathanson, Katherine, Tea, Muy Kheng, Aittomaki, Kristiina,, McCann, E. (Emma), Karlan, B.Y. (Beth), Siranoush Manoukian, Nevanlinna, H, Ramus, Susan, Nelen, MR, Schoenbuchner, I., Terry, Mary B, Pascaline Berthet, Caligo, M.A. (Maria), Goldgar, D, Mark H. Greene, Ramus, Susan J., Nevanlinna, H. (Heli), Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Ramus, Susan J,, Moysich, Kirsten, Zaffaroni, Daniela, Kets, C.M., Pankratz, V.S., Preisler-Adams, Sabine, Seynaeve, C, Katherine L Nathanson, Hansen, Thomas V O, Simard, J., Easton, D.F., Nelen, Marcel, Sabine Preisler-Adams, Per Karlsson, Bernard, L, Godwin, Andrew K., Jensen, Uffe,, Mary Beth Terry, Radice, P, Gevensleben, Heidrun,, Jones, J.L. (J Louise), Weitzel, J.N. (Jeffrey), F Singer, Christian,, Weitzel, J.N., B Daly, Mary,, Chenevix-Trench, G., Daly, Mary, Sinilnikova, O.M., Terry, Mary Beth, Ding, Y.C., Glendon, G, Hansen, T.V.O. (Thomas), Virginie Caux Moncoutier, Lucy E. Side, Marie Stenmark Askmalm, Lazaro, C., Hansen, Thomas V. O., kConFab Investigators, Imyanitov, E, Montagna, Marco,, Christoph Engel, F Easton, Douglas, Skytte, Anne Bine, Moysich, K.B. (Kirsten), Healey, S. (Sue), Seynaeve, C., Fox, S.B. (Stephen), Bernard, Loris, Kauff, N., van der Luijt, Rob B., Beth Terry, Mary,, Couch, Fergus J, Mai, Phuong, Lebrun, M. (Marine), van der Luijt, Rob B,, Garcia, EBG, Barkardottir, Rosa B., Andrulis, Irene L, Alex Murray, Kristiina Aittomäki, Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Fiebig, B. (Britta), Zachary Fredericksen, Max Yan, Niederacher, D., H Greene, Mark,, Fricker, JP, Side, Lucy, Mia Gaudet, Fassy-Colcombet, Marion,, A Caligo, Maria, DAndrea, Emma, Greene, MH, Pujol, P. (Pascal), Pharoah, Paul D, Frost, Debra,, Karlan, Beth Y, Saundra M Buys, van der Luijt, R.B., Yan, M, Kauff, Noah,, Soller, M. (Maria), Tilanus-Linthorst, M.M.A., Verheus, M, Beth Terry, Mary, Georgia Chenevix-Trench, Osorio, Ana, Greene, M.H. (Mark), Offit, Kenneth, Houghton, C. (Catherine), T Lynch, Henry,, Nielsen, Finn, de Al Hoya, Miguel, M Lindor, Noralane,, Ozcelik, Hilmi,, Debra Frost, Agnès Hardouin, Barwell, J., Varon-Mateeva, Raymonda,, M Buys, Saundra,, Miron, A.F., Jones, JL, Thomas vO Hansen, Pharoah, Paul D.P., Jensen, Uffe B, Southey, Melissa, Janavicius, Ramunas, Lynch, H. (Henry), Barrowdale, D, O'Malley, F.P., Beattie, M, L Hopper, John,, de la Hoya, M., Spurdle, Amanda B,, Spurdle, Amanda B., Kast, K., Rob B van der Luijt, Tea, Muy-Kheng,, Heinritz, W, Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Greene, Mark, Soucy, P, van Os, T, Lynch, HT, Bernard, Loris,, Melissa C. Southey, Domchek, S.M. (Susan), Diana Eccles, Os, Theo,, Alexander F Miron, Olufunmilayo I. Olopade, Jasmine Bhatia, Moysich, K.B., Tomlinson, Gail E., Evans, DG, John, E.M. (Esther), Davidson, Rosemarie,, B Moysich, Kirsten, Jones, J. Louise, Rebbeck, Tim,, Gómez García, E.B., Hamann, Ute,, Rebbeck, Tim, Peissel, B. (Bernard), Neuhausen, Susan L., Savarese, A, Jeffrey N. Weitzel, K Godwin, Andrew,, Olufunmilayo I Olopade, Isaacs, C. (Claudine), Fink-Retter, Anneliese, Cattaneo, Elisa,, Davidson, R. (Rosemarie), Gomez Garcia, EncarnaB,, Isabelle Coupier, Yan, Max,, Fiebig, B, Engel, Christoph,, Schaefer, D, P OMalley, Frances, Lesley McGuffog, Olopade, Olufunmilayo I., K Schmutzler, Rita, Offit, Kenneth,, Antoniou, Antonis C, Longy, M., Munoz-Repeto, I, Kientz, C., Andrew K Godwin, T Lynch, Henry, Phuong L. Mai, Amanda E. Toland, Eccles, D., Pasini, B., Zaffaroni, D., Britta Fiebig, Thomassen, Mads,, Fox, Stephen,, Fox, S., Katherine L. Nathanson, Mazoyer, Sylvie,, Fiebig, Britta, Lynch, Henry T, Gross, Jenny,, Sherman, M., Gerdes, A.-M., Thomassen, Mads, Meijers-Heijboer, HEJ, Side, Lucy E., Tilanus-Linthorst, Madeleine, Jones, J Louise,, Kruse, TA, Bhatia, J., Preisler-Adams, S, Barbara Pasini, CIMBA, Weitzel, Jeffrey N, Anna Wachenfeldt, von, Rebbeck, T., Thomas V. O. Hansen, Kenneth Offit, Mai, P.L., Yuan Ding, Evans, D. Gareth, A Kruse, Torben, Gomez Garcia, EncarnaB, Noralane M Lindor, Sakr, Rita,, Imyanitov, E.N. (Evgeny), Eccles, D, Schmutzler, R.K. (Rita), Kets, C. Marleen, Rob B. van der Luijt, Fink-Retter, Anneliese,, Kets, C M, Murray, Alex,, M John, Esther,, Nathanson, K.L., Robson, M., Easton, Douglas F, Gómez García, Encarna, Emma D'Andrea, Chung, W, Coupier, I. (Isabelle), Stenmark-Askmalm, M. (M.), Christian F Singer, Niederacher, Dieter, Chenevix-Trench, G, Marine Lebrun, Zaffaroni, Daniela,, Arver, B., Schoenbuchner, I. (Ines), Moysich, KB, Ruehl, I, Marion Fassy-Colcombet, Tognazzo, S. (Silvia), Mulligan, Anna Marie,, Rhiem, K. (Kerstin), Jensen, Uffe B., McGuffog, Lesley,, Eeles, Ros,, Hansen, Thomas vO, Anna Wachenfeldt, von,, C Antoniou, Antonis,, Lund University., van Wijnen, J (Juul), D. Gareth Evans, Dominique Stoppa Lyonnet, Domchek, Susan M., Pankratz, Vernon S., Marcel R. Nelen, Offit, K., Couch, FJ, Domchek, Susan M,, Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Dorkins, H. (Huw), Eeles, R, Nevanlinna, Heli, Ina Ruehl, Cook, Jackie, Schäfer, D, Dorkins, Huw,, Leone, M, Healey, S., John L. Hopper, Jacques Simard, Mary Beattie, B Moysich, Kirsten,, Wendy Chung, Savarese, A. (Antonella), Buys, Saundra M., Engel, C, Peissel, B., Meijers-Heijboer, Hanne, Simard, Jacques, C Antoniou, Antonis, Buys, S.M., S Pankratz, Vernon,, Sutter, C. (Christian), Toland, A.E. (Amanda), Verheus, M. (Martijn), Blanco, Ignacio,, Glendon, G., Y Karlan, Beth, Ding, Yuan, Bhatia, J, L Hopper, John, Stenmark-Askmalm, Marie, Louise Izatt, Szabo, Csilla, O'Malley, F.P. (Frances), L Neuhausen, Susan,, Sabine Preisler Adams, Wolfram Heinritz, Glendon, G. (Gord), Hardouin, A. (Agnès), Amanda E Toland, Nevanlinna, Heli,, Tuomas Heikkinen, Izatt, Louise,, Couch, Fergus J., Lindor, N.M., Couch, Fergus J,, Ramus, SJ, Benitez, J, Pertesi, M. (Maroulio), J. Louise Jones, Helen Gregory, Mulligan, Anna M, Houghton, C, Szabo, C, Kientz, C. (Caroline), Tilanus-Linthorst, Madeleine M A,, Couch, F.J., Izatt, L. (Louise), Nadia Boutry-Kryza, Skytte, Anne-Bine,, Jenny Gross, Montagna, Marco, Hamann, U., Duran, M, Tilanus - Linthorst, Madeleine, Ding, Yuan C, Toland, AE, Douglas F Easton, Rookus, Matti,, Pasini, B. (Barbara), Wang, X., Chenevix-Trench, Georgia,, Coupier, I, Szabo, C., Matti Rookus, Theo Os, Irene L Andrulis, Mulligan, Anna, Daly, MB, Eason, Jacqueline, Aittomaki, K, Tognazzo, S, Karlan, Beth Y., Dumont, Martine,, Verheus, M., Léone, M. (Mélanie), Godino, Javier, Laura Ottini, Hansen, Thomas V O,, Weitzel, Jeffrey N., Buys, S.S. (Saundra), Izatt, L. +999 morecore +1 more sourceThe Challenge of Handling Structured Missingness in Integrated Data Sources
Advanced Intelligent Discovery, EarlyView.As data integration becomes ever more prevalent, a new research question that emerges is how to handle missing values that will inevitably arise in these large‐scale integrated databases? This missingness can be described as structured missingness, encompassing scenarios involving multivariate missingness mechanisms and deterministic, nonrandom ...James Jackson, Marius Hofert, Eleni‐Rosalina Andrinopoulou, Niels Hagenbuch, Sarah McGough, Chris Harbron, Robin Mitra +6 morewiley +1 more sourceThe Post-Synaptic Function of Brca2 [PDF]
Scientific Reports, 2019 AbstractHomologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to form a presynaptic nucleoprotein filament.Wang, Charles X., Jimenez-Sainz, Judit, Jensen, Ryan B., Mazin, Alexander V. +3 moreopenaire +2 more sourcesBRCA1/BRCA2 [PDF]
, 2019 ?? ???????????? ???????????????????????????? ???????? ???????????????????? ?? ???????????????????? ?????????????? ???????????????????? ???????????????? ???????? ?????????????? (????) ???? ??????????????, ???? ?????????????????????? ?? ?????????????????? ?? ??????????-???????????????????? ???????????????????? ?????????? BRCA1/2, ?? ???? ?????????????????openaire +3 more sourcesThe Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron +11 morewiley +1 more sourceImprovement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study
Programme Grants for Applied Research, 2016 Background: In the UK, women are invited for 3-yearly mammography screening, through the NHS Breast Screening Programme (NHSBSP), from the ages of 47–50 years to the ages of 69–73 years.D Gareth Evans, Susan Astley, Paula Stavrinos, Elaine Harkness, Louise S Donnelly, Sarah Dawe, Ian Jacob, Michelle Harvie, Jack Cuzick, Adam Brentnall, Mary Wilson, Fiona Harrison, Katherine Payne, Anthony Howell +13 moredoaj +1 more source
