Results 71 to 80 of about 46,564 (215)
Exploring role of 5hmC as potential marker of chemoresistance
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance
Suhas S. Kharat, Shyam K. Sharan
doaj +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Early onset colorectal cancer (EoCRC), commonly defined as colorectal cancer diagnosed in people under 50 years of age, is increasing in incidence in Australia and New Zealand. The underlying cause of this remains unclear, despite its growing public health importance.
Tiffany J. Cherry +2 more
wiley +1 more source
Breast Angiosarcoma: 15‐Years Experience
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Breast angiosarcoma is a rare, aggressive malignancy that can be primary (PAS) or secondary (SAS). This study evaluates the management and outcomes of breast angiosarcoma in a single‐center breast/surgical oncology unit. Methods A retrospective review was conducted on patients with histologically confirmed PAS or SAS who underwent ...
Gaik Si Quah +2 more
wiley +1 more source
Information Discrimination and Its Implications on Distributing Healthcare Costs Fairly
Bioethics, EarlyView.ABSTRACT When healthcare resources are scarce, they ought to be distributed fairly across society. For some theories of distribution, an assessment of individual health risk is required for a fair distribution of both healthcare resources and burdens. Despite this requirement, prevailing theories underappreciate the cost of information on health risk ...
Harisan U. Nasir
wiley +1 more source
Balkan Journal of Medical GeneticsThe purpose of our study is to expedite cancer diagnosis through the development of software for rapid detection of hereditary breast cancer (BC) with negative BRCA1/2 on MATLAB, utilizing a fuzzy logic system with several variants of genes associated ...
Senturk N +8 more
doaj +1 more source
Cancer Science, EarlyView.In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota +8 more
wiley +1 more source
BRCA2 c.8827C>T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer
Molecular Genetics & Genomic Medicine, 2020 Background Mutations in the BRCA2 DNA repair associated gene (BRCA2) are associated with the development of breast cancer, with different ethnic mutations at different sites.
Jiangfen Wang +3 more
doaj +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Early but Quality Diagnosis: On Breast Cancer and Its Risk Factors [Letter]
Breast Cancer: Targets and Therapy, 2023 Syeda Sakina Zehra, Zoha Turabee, Mohadisa Asif Rawalia Karachi Medical and Dental College, Karachi, PakistanCorrespondence: Syeda Sakina Zehra, Tel +92 3322609216, Email szehra362@gmail ...
Zehra SS, Turabee Z, Rawalia MA
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International Journal of Dermatology, EarlyView.ABSTRACT Background There is a lack of knowledge in full‐body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial ...
Jincong Q. Freeman +4 more
wiley +1 more source