Results 71 to 80 of about 65,232 (224)
GenProb‐PCSM: A Simplified Weighted Germline Score for Prostate Cancer‐Specific Mortality
The Prostate, EarlyView.ABSTRACT Background We previously developed a tier‐based germline classification using the National Comprehensive Cancer Network (NCCN)‐recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)‐specific mortality (PCSM).
Jun Wei +14 more
wiley +1 more source
Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma [PDF]
, 2009 Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated.
Chandramohan, Kurapaty Venkatapoorna +19 more
core +1 more source
Impact of sleep insufficiency and recovery on cancer development
Sleep Research, EarlyView.Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley +1 more source
RISK FACTORS OF OVARIAN CANCER AND POSSIBLE PREVENTIVE STRATEGIES
Фундаментальная и клиническая медицина, 2018 Here we review the current data on prevention, diagnosis, and treatment of ovarian cancer, one of the most prevalent genitourinary cancers characterized by high mortality and case fatality rates due to the lack of efficient screening and treatment ...
OLGA B. Karelina +2 more
doaj
Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study
Ultrasound in Obstetrics &Gynecology, EarlyView.ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone +17 more
wiley +1 more source
Chromatin Remodeling in Response to BRCA2-Crisis
Cell Reports, 2019 Summary: Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies.
Joshua J. Gruber +8 more
doaj +1 more source
Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020 BRCA1 và BRCA2 là hai gen ức chế khối u quan trọng. Việc đột biến hai gen này ở bệnh nhân ung thư biểu mô buồng trứng dòng mầm và dòng sinh dưỡng thì đáp ứng tốt hơn với thuốc ức chế enzyme poly(ADP-ribose) polymerase inhibitor (PARPi).
Ngo Dai Phu +11 more
doaj +1 more source
Inherited mutations impair responses to environmental carcinogens: Cancer prevention in mutation carriers [PDF]
, 2011 Some environmental carcinogens may be responsible for a modest increase in the numbers of cancers after years of exposure. Economic or political factors weigh against widespread bans of carcinogens.
Bernard Friedenson, Bernard Friedenson
core +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price +12 more
wiley +1 more source
El cáncer hereditario en mujeres
Arbor: Ciencia, Pensamiento y Cultura, 2015 La mayoría de los casos de cáncer son esporádicos, entre un 20-30% presentan agregación familiar, mientras que solo el 5 -10% son de carácter hereditario.
Rafael Morales Chamorro +7 more
doaj +1 more source