Results 91 to 100 of about 60,203 (254)
Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020 BRCA1 và BRCA2 là hai gen ức chế khối u quan trọng. Việc đột biến hai gen này ở bệnh nhân ung thư biểu mô buồng trứng dòng mầm và dòng sinh dưỡng thì đáp ứng tốt hơn với thuốc ức chế enzyme poly(ADP-ribose) polymerase inhibitor (PARPi).
Ngo Dai Phu +11 more
doaj +1 more source
Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community
Prenatal Diagnosis, EarlyView.ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum +4 more
wiley +1 more source
The Molecular Perspective: RAD51 and BRCA2 [PDF]
STEM CELLS, 2005 Learning Objectives After completing this course, the reader will be able to: Discuss homologous recombination and its role in cancer. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com
openaire +3 more sources
RISK FACTORS OF OVARIAN CANCER AND POSSIBLE PREVENTIVE STRATEGIES
Фундаментальная и клиническая медицина, 2018 Here we review the current data on prevention, diagnosis, and treatment of ovarian cancer, one of the most prevalent genitourinary cancers characterized by high mortality and case fatality rates due to the lack of efficient screening and treatment ...
OLGA B. Karelina +2 more
doaj
El cáncer hereditario en mujeres
Arbor: Ciencia, Pensamiento y Cultura, 2015 La mayoría de los casos de cáncer son esporádicos, entre un 20-30% presentan agregación familiar, mientras que solo el 5 -10% son de carácter hereditario.
Rafael Morales Chamorro +7 more
doaj +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective Prenatal sequencing of fetuses with abnormalities detected on imaging is expanding globally. Debate continues over whether variants of uncertain significance (VUS) should be reported prenatally, with some recent national position statements opposing this.
A. Gibbs +13 more
wiley +1 more source
BRCA1 and BRCA2 mutations in Scotland and Northern Ireland [PDF]
, 2003 BRCA1 and BRCA2 mutations have been identified in 107 families in Scotland and Northern Ireland. Ninety-seven of these families had been referred to regional cancer genetics centres and a further 10 were identified from a sequential series of male breast
The Scottish/Northern Irish BRCA1/BRCA2 Consortium
core
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
, 2020 International audienceThe BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (PLK1).
Miron, Simona +12 more
core +1 more source
Human BRCA2 can complement the loss of Brca2 in mouse embryonic stem cells.
, 2023 (a) Schematic overview of the generation of mouse ESCs containing a single copy of BRCA2. Parental mouse ES cells (PL2F7) contain one conditional Brca2 allele floxed by a HPRT minigene cassette and one deleted Brca2 allele [35].
Sounak Sahu (3950660) +14 more
core +1 more source
Asian Journal of Medical Sciences, 2016 Background: Breast cancer occurs in both men and women, although it is more prevalent among women. Mammography is generally the diagnostic imaging modality of choice, but it is limited in the detection of breast cancer in young women, aged 18-45 years ...
GM Akpaniwo
doaj +1 more source