Results 1 to 10 of about 44,419 (235)

Genetic modulation of RNA splicing rescues BRCA2 function in mutant cells

Life Science Alliance
This study provides proof of principle for the therapeutic potential of splicing modulation as a strategy to rescue BRCA2 function in mutant cells. Variants in the hereditary cancer-associated BRCA1 and BRCA2 genes can alter RNA splicing, producing ...
Beatriz Anjo Lima, Ana Carolina Pais, Juliette Dupont, Patrícia Dias, Noélia Custódio, Ana Berta Sousa, Maria Carmo-Fonseca, Célia Carvalho   +7 more
doaj   +1 more source

Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.

PLoS Genetics, 2008
Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. BRCA2 maintains genome stability in part through the regulation of Rad51-dependent homologous recombination. Much about its precise function in
Martha Klovstad, Uri Abdu, Trudi Schüpbach   +2 more
doaj   +1 more source

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2

Nature Communications, 2023
The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby, Luay Joudeh, Katie Cobbett, Luca Pellegrini   +3 more
doaj   +1 more source

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.

PLoS Genetics, 2016
Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that is essential for maintaining genomic integrity. Among the proteins that physically interact with BRCA2, Partner and Localizer of BRCA2 (PALB2), which binds to the N ...
Suzanne A Hartford, Rajanikant Chittela, Xia Ding, Aradhana Vyas, Betty Martin, Sandra Burkett, Diana C Haines, Eileen Southon, Lino Tessarollo, Shyam K Sharan   +9 more
doaj   +1 more source

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.

PLoS Genetics, 2018
The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin, Michelle Pherson, Maria Gause, Dale Dorsett   +3 more
doaj   +1 more source

Protein Annotation of Breast-cancer-related Proteins with Machine-learning Tools

Makara Journal of Science, 2020
One of the primary contributors to the mortality of women is breast cancer. Several approaches are used to cure it, but recurrence occurs in 79% of the cases because the underlying mechanism of the protein molecules is not carefully ex-amined.
Arli Aditya Parikesit , David Agustriawan, Rizky Nurdiansyah   +2 more
doaj   +1 more source

Estimating copy number to determine BRCA2 deletion status and to expect prognosis in localized prostate cancer

Cancer Medicine, 2023
Background The significance of BRCA alterations has been implicated in the development of metastatic castration‐resistant prostate cancer (PC). The details of the frequency and significance of BRCA alterations in localized PC remain unknown.
Takuhisa Nukaya, Makoto Sumitomo, Eiji Sugihara, Mayu Takeda, Sachio Nohara, Shigeki Tanishima, Masashi Takenaka, Kenji Zennami, Kiyoshi Takahara, Ryoichi Shiroki, Hideyuki Saya   +10 more
doaj   +1 more source

Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay

Breast Cancer Research, 2020
Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance.
Nirmala Sirisena, Kajal Biswas, Teresa Sullivan, Stacey Stauffer, Linda Cleveland, Eileen Southon, Vajira H. W. Dissanayake, Shyam K. Sharan   +7 more
doaj   +1 more source

Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens , a Basidiomycota yeast

Life Science Alliance
Identification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.
Maierdan Palihati, Hiroshi Iwasaki, Hideo Tsubouchi   +2 more
doaj   +1 more source

A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 protein [v2; ref status: indexed, http://f1000r.es/1wc]

F1000Research, 2013
Mutations in the BRCA2 tumor suppressor protein leave individuals susceptible to breast, ovarian and other cancers. The BRCA2 protein is a critical component of the DNA repair pathways in eukaryotes, and also plays an integral role in fostering genomic ...
Sandeep Chakraborty
doaj   +1 more source