Results 11 to 20 of about 44,419 (235)

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. [PDF]

Cancers (Basel), 2019
The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract therapy-induced DNA damage.
van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R.   +8 more
europepmc   +8 more sources

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2 -Mutated Ovarian Carcinoma [PDF]

Cancer Research, 2009
Abstract Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma ...
Sakai, Wataru, Swisher, Elizabeth M, Jacquemont, Céline, Chandramohan, Kurapaty Venkatapoorna, Couch, Fergus J, Langdon, Simon P, Wurz, Kaitlyn, Higgins, Jake, Villegas, Emily, Taniguchi, Toshiyasu   +9 more
openaire   +5 more sources

Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer [PDF]

International Journal of Cancer, 1998
Many epidemiological studies have reported an association between breast and prostate cancer. BRCA2 functions as a tumour-suppressor gene in about 35% of large familial breast-cancer clusters; its role in the pathogenesis of sporadic breast cancer is less clear.
Stephen M. Edwards, William D. Dunsmuir, Cheryl E. Gillett, Sunil R. Lakhani, Catherine Corbishley, Martin Young, Roger S. Kirby, David P. Dearnaley, Anna Dowe, Audrey Ardern‐Jones, Jo Kelly, Nigel Spurr, Diana M. Barnes, Rosalind A. Eeles   +13 more
core   +6 more sources

Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption [PDF]

Cell Death & Disease, 2017
AbstractBRCA2 encodes a protein with a fundamental role in homologous recombination that is essential for normal development. Carrier status of mutations in BRCA2 is associated with familial breast and ovarian cancer, while bi-allelic BRCA2 mutations can cause Fanconi anemia (FA), a cancer predisposition syndrome with cellular cross-linker ...
Stefan Meyer, Adam Stevens, Roberto Paredes, Marion Schneider, Michael J Walker, Andrew J K Williamson, Maria-Belen Gonzalez-Sanchez, Stephanie Smetsers, Vineet Dalal, Hsiang Ying Teng, Daniel J White, Sam Taylor, Joanne Muter, Andrew Pierce, Chiara de Leonibus, Davy A P Rockx, Martin A Rooimans, Elaine Spooncer, Stacey Stauffer, Kajal Biswas, Barbara Godthelp, Josephine Dorsman, Peter E Clayton, Shyam K Sharan, Anthony D Whetton   +24 more
openaire   +6 more sources

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

Nature Communications, 2020
The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.
Åsa Ehlén, Charlotte Martin, Simona Miron, Manon Julien, François-Xavier Theillet, Virginie Ropars, Gaetana Sessa, Romane Beaurepere, Virginie Boucherit, Patricia Duchambon, Ahmed El Marjou, Sophie Zinn-Justin, Aura Carreira   +12 more
doaj   +2 more sources

Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein [PDF]

Molecular Cell, 2023
Ondřej Belan, Simon J Boulton
exaly   +2 more sources

Interactions between human BRCA2 protein and the meiosis‐specific recombinase DMC1 [PDF]

The EMBO Journal, 2007
Germline mutations in BRCA2 predispose to hereditary breast cancers. BRCA2 protein regulates recombinational repair by interaction with RAD51 via a series of degenerate BRC repeat motifs encoded by exon 11 (BRCA2(996-2113)), and an unrelated C-terminal domain (BRCA2(3265-3330)). BRCA2 is also required for meiotic recombination. Here, we show that human
Thorslund, T, Esashi, F, West, S
openaire   +3 more sources

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein [PDF]

Molecular Cell, 2001
Individuals carrying BRCA2 mutations are predisposed to breast and ovarian cancers. Here, we show that BRCA2 plays a dual role in regulating the actions of RAD51, a protein essential for homologous recombination and DNA repair. First, interactions between RAD51 and the BRC3 or BRC4 regions of BRCA2 block nucleoprotein filament formation by RAD51 ...
Davies, Adelina A, Masson, Jean-Yves, McIlwraith, Michael J, Stasiak, Alicja Z, Stasiak, Andrzej, Venkitaraman, Ashok R, West, Stephen C   +6 more
openaire   +3 more sources

Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition. [PDF]

PLoS ONE
Microcephalin-1 (MCPH1) is a tumour suppressor protein that regulates homologous recombination repair (HRR) and is down-regulated in several tumour types.
Isobel G Chapman, Xueqin Wu, Stephany Veuger, Paul A Jowsey   +3 more
doaj   +2 more sources

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1 [PDF]

Human Molecular Genetics, 2003
Fanconi anaemia (FA) is an autosomal recessive genetic disorder characterized by progressive bone marrow failure, multiple congenital abnormalities, and an increased risk of cancer. FA cells are characterized by chromosomal instability and hypersensitivity to DNA interstrand crosslinking agents.
Hussain, S, Witt, E, Huber, P A J, Medhurst, A L, Ashworth, A, Mathew, C G   +5 more
openaire   +4 more sources