Results 21 to 30 of about 44,419 (235)
Middle East Journal of Cancer, 2013 Background: Ovarian cancer is the leading cause of death among gynecological cancers. Changes in the methylation of BRCA1 and BRCA2 may be an effective mechanism for breast and ovarian cancer.
Ahmad Shabanizadeh +8 more
doaj +1 more source
Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
eLife, 2021 Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection.
Maarten W Paul +7 more
doaj +1 more source
Parasites & Vectors, 2022 Background Malaria is a major global parasitic disease caused by species of the genus Plasmodium. Zygotes of Plasmodium spp. undergo meiosis and develop into tetraploid ookinetes, which differentiate into oocysts that undergo sporogony.
Yasunaga Yoshikawa +15 more
doaj +1 more source
Biomolecules, 2021 The maintenance of genome integrity in the cell is an essential process for the accurate transmission of the genetic material. BRCA2 participates in this process at several levels, including DNA repair by homologous recombination, protection of stalled ...
Manon Julien +5 more
doaj +1 more source
Exploring the Mechanisms of Total Saponins of Black Ginseng and Ginsenoside Rg3 Against Doxorubicin-Induced Cardiotoxicity. [PDF]
Food Sci NutrTSF and Rg3 demonstrate significant cardioprotective effects against DOX‐induced cardiotoxicity (DIC) by mitigating oxidative stress, inflammation, and apoptosis while preserving mitochondrial function. These findings provide novel insights into the clinical relevance of TSF and Rg3 in the management of DIC.
Liu L +5 more
europepmc +2 more sources
Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination [PDF]
, 2021 Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation ...
Zhang, Jingjing
core +1 more source
Frontiers in Genetics, 2022 The BRCA2 germline missense variant, R3052W, resides in the DNA binding domain and has been previously classified as a pathogenic allele. In this study, we sought to determine how R3052W alters the cellular functions of BRCA2 in the DNA damage response ...
Judit Jimenez-Sainz +4 more
doaj +1 more source
BRCA2 c.8827C>T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer
Molecular Genetics & Genomic Medicine, 2020 Background Mutations in the BRCA2 DNA repair associated gene (BRCA2) are associated with the development of breast cancer, with different ethnic mutations at different sites.
Jiangfen Wang +3 more
doaj +1 more source
The Could Regulate the Sensitivity of Ovarian Cancer Cells to Platinum-Based Drugs
Technology in Cancer Research & Treatment, 2020 Background and Objective: We have previously reported that BRCA2 N372 H i.a.1342A>C heterozygous variation presented in platinum-resistant patients. This study aimed to further investigate the mechanism of BRCA2 N372 H mutation in the development of ...
Zhen-Hua Du PhD +3 more
doaj +1 more source
Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas [PDF]
BMC Cancer, 2009 Abstract Background Loss of heterozygosity of chromosome 10q26 has been shown to be associated with the aggressiveness of astrocytic tumors (or astrocytomas), but the responsible gene(s) residing in this region has not been fully identified. The BCCIP gene is located at chromosome 10q26. It encodes a BRCA2 and CDKN1A (
Merlo Adrian +4 more
openaire +3 more sources