Results 21 to 30 of about 67,862 (241)
Rapid Evolution of BRCA1 and BRCA2 in Humans and Other Primates [PDF]
, 2014 The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA.
Demogines, Ann M. +6 more
core +3 more sources
Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas [PDF]
BMC Cancer, 2009 Abstract Background Loss of heterozygosity of chromosome 10q26 has been shown to be associated with the aggressiveness of astrocytic tumors (or astrocytomas), but the responsible gene(s) residing in this region has not been fully identified. The BCCIP gene is located at chromosome 10q26. It encodes a BRCA2 and CDKN1A (
Merlo Adrian +4 more
openaire +3 more sources
The PARP-1 inhibitor Olaparib causes retention of γ-H2AX foci in BRCA1 heterozygote cells following exposure to gamma radiation [PDF]
, 2013 This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 Emma C. Bourton et al. This is an open access article distributed under the Creative Commons Attribution Li-cense, which permits unrestricted use ...
Adam Zahir, S +4 more
core +1 more source
PALB2 self-interaction controls homologous recombination. [PDF]
, 2012 PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
core +1 more source
The BRC repeats are conserved in mammalian BRCA2 proteins [PDF]
Human Molecular Genetics, 1997 The breast cancer susceptibility gene BRCA2 encodes a protein of 3418 amino acids which does not exhibit substantial sequence similarity to any other protein in the public databases. A dot matrix comparison of BRCA2 with itself revealed an eight times repeated motif in the segment of the protein encoded by exon 11.
G, Bignell +4 more
openaire +2 more sources
Journal of Medical Case Reports, 2023 Background The BRCA2 gene is a well-known tumor suppressor gene implicated in breast and ovarian cancers. BRCA1/2 mutations can be sensitive to poly ADP-ribose polymerase (PARP) inhibitors such as olaparib.
Auro del Giglio +3 more
doaj +1 more source
Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism
Frontiers in Oncology, 2022 Mutations in BRCA2 gene increase the risk for breast cancer and for other cancer types, including pancreatic and prostate cancer. Since its first identification as an oncosupressor in 1995, the best-characterized function of BRCA2 is in the repair of DNA
Alessandra Costanza +13 more
doaj +1 more source
Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer [PDF]
, 2002 BACKGROUND: Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified
Dalton, Ann +6 more
core +2 more sources
Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption [PDF]
Cell Death & Disease, 2017 AbstractBRCA2 encodes a protein with a fundamental role in homologous recombination that is essential for normal development. Carrier status of mutations in BRCA2 is associated with familial breast and ovarian cancer, while bi-allelic BRCA2 mutations can cause Fanconi anemia (FA), a cancer predisposition syndrome with cellular cross-linker ...
Stefan Meyer +24 more
openaire +5 more sources
Complex-based analysis of dysregulated cellular processes in cancer [PDF]
, 2014 Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum +6 more
core +1 more source