Results 41 to 50 of about 67,862 (241)
Nature Communications, 2020 In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.
Jingjing Zhang +14 more
doaj +1 more source
Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
Frontiers in Genetics, 2016 Breast cancer type 2, early onset susceptibility gene (BRCA2) is a major component of the homologous recombination DNA repair pathway. It acts as a tumor suppressor whose function is often lost in cancers.
Elena Mogilyansky +6 more
doaj +1 more source
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
Nature Communications, 2020 The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.
Åsa Ehlén +12 more
doaj +1 more source
Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2. [PDF]
PLoS ONE, 2013 Mutations in BRCA1 and BRCA2 are responsible for a large proportion of breast-ovarian cancer families. Protein-truncating mutations have been effectively used in the clinical management of familial breast cancer due to their deleterious impact on protein
Eric Tram, Sevtap Savas, Hilmi Ozcelik
doaj +1 more source
BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
eLife, 2022 Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication ...
Judit Jimenez-Sainz +7 more
doaj +1 more source
An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]
, 2014 Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan +2 more
core +4 more sources
Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers [PDF]
Journal of Clinical Oncology, 2009 Purpose Mutations in the BRCA2 gene are dominantly inherited but cause cancers when the wild-type allele has loss of heterozygosity (LOH) within the cancer. Because most disease-associated BRCA2 mutations are protein-truncating mutations, a test for truncated BRCA2 proteins should identify most BRCA2 hereditary cancers.
Patrice, Watson +5 more
openaire +2 more sources
Low levels of BRCA1 protein expression predict a worse prognosis in stage I–II colon cancer
The International Journal of Biological Markers, 2021 Background: BRCA1 and BRCA2 have been well studied for their roles in tumorigeneis, plus cancer diagnosis and treatment, but their prognostic value in colon cancer, especially for early-stage cancer, has not been fully illuminated.
Changzheng Du +4 more
doaj +1 more source
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment [PDF]
, 2016 Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients experience relapses with a median ...
Caruso, Davide +4 more
core +2 more sources