Results 61 to 70 of about 44,419 (235)

Low levels of BRCA1 protein expression predict a worse prognosis in stage I–II colon cancer

The International Journal of Biological Markers, 2021
Background: BRCA1 and BRCA2 have been well studied for their roles in tumorigeneis, plus cancer diagnosis and treatment, but their prognostic value in colon cancer, especially for early-stage cancer, has not been fully illuminated.
Changzheng Du, Yifan Peng, Yiping He, Guoan Chen, Hao Chen   +4 more
doaj   +1 more source

Novel BRCA2-Interacting Protein, LIMD1, Is Essential for the Centrosome Localization of BRCA2 in Esophageal Cancer Cell

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2016
Mutation of breast cancer 2, early onset (BRCA2) has been identified as a vital risk factor for esophageal cancer (EC). To date, several proteins have been reported as BRCA2-interacting proteins and are associated with multiple biological processes. This study’s aim was to identify a novel interactive protein of BRCA2 and to explore its functional ...
Hou, Xiaobin, Li, Tinghui, Ren, Zhipeng, Liu, Yang   +3 more
openaire   +3 more sources

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein [PDF]

Proceedings of the National Academy of Sciences, 1997
The human RAD51 protein is a homologue of the bacteria RecA and yeast RAD51 proteins that are involved in homologous recombination and DNA repair. RAD51 interacts with proteins involved in recombination and also with tumor suppressor proteins p53 and breast cancer susceptibility gene 1 (BRCA1).
R, Mizuta, J M, LaSalle, H L, Cheng, A, Shinohara, H, Ogawa, N, Copeland, N A, Jenkins, M, Lalande, F W, Alt   +8 more
openaire   +2 more sources

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Sainu Ravindran, Ravindran, S, Yasaei, H, Ester Sapir, Predrag Slijepcevic, Suliman Al-Wahiby, Hemad Yasaei, Gozaly-Chianea, Y, Sapir, E, Al-Wahiby, S   +11 more
core   +1 more source

Interaction between Arabidopsis Brca2 and its partners Rad51, Dmc1, and Dss1 [PDF]

, 2006
*This article is free to read on the publisher's website*\ud \ud The Arabidopsis (Arabidopsis thaliana) orthologs of Brca2, a protein whose mutations are involved in breast cancer in humans, were previously shown to be essential at meiosis. In an attempt
N. Siaud, M.-P. Doutriaux, Siaud, Nicolas, E. Dubois, Doutriaux, Marie-Pascale, Dubois, Emeline, E. Dray, Dray, Eloise   +7 more
core   +1 more source

Assessment of PALB2 as a candidate melanoma susceptibility gene.

PLoS ONE, 2014
Partner and localizer of BRCA2 (PALB2) interacts with BRCA2 to enable double strand break repair through homologous recombination. Similar to BRCA2, germline mutations in PALB2 have been shown to predispose to Fanconi anaemia as well as pancreatic and ...
Lauren G Aoude, Mai Xu, Zhen Zhen Zhao, Michael Kovacs, Jane M Palmer, Peter Johansson, Judith Symmons, Jeffrey M Trent, Nicholas G Martin, Grant W Montgomery, Kevin M Brown, Nicholas K Hayward   +11 more
doaj   +1 more source

No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

BMC Research Notes, 2009
Background Germline mutations in the BRCA2 gene have been suggested to account for about 5% of familial prostate cancer; mutations have been reported in 2% of early onset (i.e., ≤ 55 years) prostate cancer cases and a segregating founder mutation has ...
Allen-Brady Kristina, Farnham James M, Camp Nicola J, Karlins Eric, Ostrander Elaine A, Cannon-Albright Lisa A   +5 more
doaj   +1 more source

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase [PDF]

Oncogene, 2000
A substantial proportion of familial breast cancers have mutations within the BRCA2 gene. The product of this gene has been implicated in DNA repair and in the regulation of transcription. We have previously identified at the amino-terminus of BRCA2 a transcriptional activation domain whose importance is highlighted by the presence of predisposing ...
Fuks, François, Milner, J, Hughes-Davies, L, Kouzarides, Tony   +3 more
openaire   +3 more sources

Breast cancer risks associated with missense variants in breast cancer susceptibility genes

Genome Medicine, 2022
Background Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks associated with missense variants in these genes are uncertain.
Leila Dorling, Sara Carvalho, Jamie Allen, Michael T. Parsons, Cristina Fortuno, Anna González-Neira, Stephan M. Heijl, Muriel A. Adank, Thomas U. Ahearn, Irene L. Andrulis, Päivi Auvinen, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Michael Bremer, Ignacio Briceno, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, NBCS Collaborators, J. Margriet Collée, Kamila Czene, Joe Dennis, Thilo Dörk, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, Graham G. Giles, Gord Glendon, Pascal Guénel, Melanie Gündert, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Elaine F. Harkness, Mikael Hartman, Frans B. L. Hogervorst, Antoinette Hollestelle, Reiner Hoppe, Anthony Howell, kConFab Investigators, SGBCC Investigators, Anna Jakubowska, Audrey Jung, Elza Khusnutdinova, Sung-Won Kim, Yon-Dschun Ko, Vessela N. Kristensen, Inge M. M. Lakeman, Jingmei Li, Annika Lindblom, Maria A. Loizidou, Artitaya Lophatananon, Jan Lubiński, Craig Luccarini, Michael J. Madsen, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Roger L. Milne, Nur Aishah Mohd Taib, Kenneth Muir, Heli Nevanlinna, William G. Newman, Jan C. Oosterwijk, Sue K. Park, Paolo Peterlongo, Paolo Radice, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Xueling Sim, Melissa C. Southey, Harald Surowy, Maija Suvanto, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J. van Asperen, Regina Waltes, Qin Wang, Xiaohong R. Yang, Paul D. P. Pharoah, Marjanka K. Schmidt, Javier Benitez, Bas Vroling, Alison M. Dunning, Soo Hwang Teo, Anders Kvist, Miguel de la Hoya, Peter Devilee, Amanda B. Spurdle, Maaike P. G. Vreeswijk, Douglas F. Easton   +108 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source