Results 41 to 50 of about 72,402 (211)

Breast cancer risk and 6q22.33: combined results from breast cancer association consortium and consortium of investigators on modifiers of BRCA1/2 [PDF]

open access: yes, 2012
Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present
Schürmann, Peter   +999 more
core   +1 more source

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors

open access: yesBMC Cancer, 2007
Background The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the ubiquitination of proteins; however its precise functions remain to be fully understood ...
Pinnaduwage Dushanthi   +3 more
doaj   +1 more source

Investigation of the relationship of TNFRSF11A gene polymorphisms with breast cancer development and metastasis risk in patients with BRCA1 or BRCA2 pathogenic variants living in the Trakya region of Turkey

open access: yesBalkan Journal of Medical Genetics, 2021
Modifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of BRCA1 or BRCA2.
Özdemir K   +7 more
doaj   +1 more source

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer

open access: yes, 2001
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast ...
Bruce AJ Ponder   +13 more
core   +1 more source

A Founder Mutation of the BRCA1‐Gene in Western Sweden [PDF]

open access: yesDisease Markers, 1999
AIM: To study the geographical distribution of the families with the founder mutation nt3166ins5 in the BRCA1 gene. To describe the phenotype and confirm mutational status also in deceased cases. METHOD: In the cancer counselling clinic of western Sweden (pop. 1.6 mill) about 204 families have been investigated since May 1995.
Einbeigi, Zakaria   +7 more
openaire   +1 more source

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]

open access: yes, 2011
NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela   +20 more
core   +1 more source

Comprehensive genomic profile of heterogeneous long follow-up triple-negative breast cancer and its clinical characteristics shows DNA repair deficiency has better prognostic [PDF]

open access: yes, 2020
Triple-negative breast cancer (TNBC) presents a marked diversity at the molecular level, which promotes a clinical heterogeneity that further complicates treatment.
Rosalía Quezada-Urban   +58 more
core   +1 more source

BRCA1 mutation influences progesterone response in human benign mammary organoids

open access: yesBreast Cancer Research, 2019
Background Women, who carry a germline BRCA1 gene mutation, have a markedly increased risk of developing breast cancer during their lifetime. While BRCA1 carriers frequently develop triple-negative, basal-like, aggressive breast tumors, hormone signaling
Batzaya Davaadelger   +5 more
doaj   +1 more source

Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. [PDF]

open access: yesPLoS Genetics, 2010
A large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2.
Logan C Walker   +5 more
doaj   +1 more source

Determination of BRCA1 and BRCA2 Gene Mutations in Patients at Risk of Breast and/or Ovarian Cancer by Next Generation Sequencing in the Isparta Region

open access: yesBatı Karadeniz Tıp Dergisi, 2021
and/or ovarian cancers. BRCA1 / BRCA2 genes are associated with 20-25% of these diseases. Thespectrum and prevalence of BRCA1 and BRCA2 gene mutations are different in each population.Determining the prevalence of pathogenic mutations in susceptibility ...
Muhammet Yusuf Tepebaşı   +3 more
doaj   +1 more source

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